Juniper oil inhibits the heat shock-induced apoptosis via preventing the caspase-3 activation in human astrocytes CCF-STTG1 cells

Na, Ho-Jeong; Koo, Hyun‐Na; Lee, Gil-Goo; Yoo, Su-Jin; Park, Jae-Hwang; Lyu, Yeung-Su; Kim, Hyung-Min

doi:10.1016/s0009-8981(01)00699-4

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Nakano found that camphor inhibited apoptosis in human oral tumor cells when other ketones induced it 59. Na et al60 examined the effect of juniper oil on apoptosis in human brain astrocytes. Heat shock–induced apoptosis of these cells was blocked by pretreatment with juniper oil.…”

Section: Discussionmentioning

confidence: 99%

<p>Essential oils, asthma, thunderstorms, and plant gases: a prospective study of respiratory response to ambient biogenic volatile organic compounds (BVOCs)</p>

Gibbs

2019

JAA

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Purpose: Prevailing opinion is that wind-pollinated plants affect asthma negatively and that insect- pollinated ones do not. “Thunderstorm” asthma, too, is attributed to bursting grass pollens. Additional biogenic volatile organic compounds (BVOCs) are identified here. Essential oils’ BVOCs are inhaled from plants, oil diffusers, candles, room “fresheners”, perfumes, and hygiene products. Claims of BVOC “safety” for sensitive respiratory systems are questioned. Methods: Fourteen volunteers, of mixed-age and gender, with seasonal asthma recorded peak expiratory flow (PEF) and 11 symptom scores. BVOCs were collected on Tenax tubes from ambient air in autumn and spring, as were live flower emissions, before and after a thunderstorm. Gas chromatography–mass spectrometry analysis identified frequently occurring BVOCs. Air spora, meteorological, outdoor air pollution variables, and BVOCs predict respiratory symptoms in univariate linear regression models, seasonally. Results: Increased pinene, camphor, linalool, linalyl acetate, benzaldehyde, and benzoic acid predict respiratory symptoms, including reduced PEF, and increased nasal congestion; day length, atmospheric pressure and temperature predict symptoms in both seasons, differently; other variables predict a range of symptoms (0.0001≤ p ≤0.05). Thunder predicts different BVOC emissions in spring, compared to autumn ( p ≤0.05). An uncut Grevillea flower emitted linalool and hexenal before a storm; the latter is also emitted from cut grass. Increased nitrogen oxides and pinene in autumn may combine to form harmful oxidation products. Conclusion: This research supports BVOCs as contributors to seasonal asthma and allergic rhinitis, and “thunderstorm” asthma. Pinene emissions from Myrtaceae species ( Eucalyptus, Melaleuca, Leptospermum, Callistemon ), Brassicaceae (canola), and conifers, worldwide, may induce respiratory inflammation and maintain it, by inhibiting eosinophilic apoptosis. Widely used essential oil products containing BVOCs, like linalool, are associated here with respiratory symptoms. Lagged responses suggest that users’ cognitive associations between exposure and response are unlikely, increasing potential for impaired health for vulnerable children.

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Section: Discussionmentioning

confidence: 99%

<p>Essential oils, asthma, thunderstorms, and plant gases: a prospective study of respiratory response to ambient biogenic volatile organic compounds (BVOCs)</p>

Gibbs

2019

JAA

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Juniperus communis Suppresses Melanoma Tumorigenesis by Inhibiting Tumor Growth and Inducing Apoptosis

et al. 2019

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Melanoma, which has a high metastatic capacity and death rate, is a common skin cancer in Western countries. The purpose of this study was to address whether Juniperus communis (JCo) extract is effective in the suppression of melanoma and to elucidate the anticancer mechanisms involved in vitro and in vivo. The antitumor capacities of JCo extract on tumor suppression and toxicity were evaluated and the results demonstrated that the tumor burden was reduced via mediation of cell cycle, reduction of autocrine signaling, and induction of apoptosis. Moreover, JCo extract significantly prolonged the survival rate of the test subjects with only low pathological and physiological toxicity. Additionally, JCo extract also reduced cancer stem cell-related angiogenic and metastatic proteins in the process of tumor elimination. Based on these results, this study suggests that JCo extract suppresses tumor growth and induces apoptosis, and JCo extract may be useful for the prevention of melanoma tumorigenesis.

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Juniper oil inhibits the heat shock-induced apoptosis via preventing the caspase-3 activation in human astrocytes CCF-STTG1 cells

Cited by 2 publications

References 34 publications

<p>Essential oils, asthma, thunderstorms, and plant gases: a prospective study of respiratory response to ambient biogenic volatile organic compounds (BVOCs)</p>

<p>Essential oils, asthma, thunderstorms, and plant gases: a prospective study of respiratory response to ambient biogenic volatile organic compounds (BVOCs)</p>

Juniperus communis Suppresses Melanoma Tumorigenesis by Inhibiting Tumor Growth and Inducing Apoptosis

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