Autonomous driving has attracted great attention from both academics and industries. To realise autonomous driving, Deep Imitation Learning (DIL) is treated as one of the most promising solutions, because it improves autonomous driving systems by automatically learning a complex mapping from human driving data, compared to manually designing the driving policy. However, existing DIL methods cannot generalise well across domains, that is, a network trained on the data of source domain gives rise to poor generalisation on the data of target domain. In the present study, we propose a novel brain-inspired deep imitation method that builds on the evidence from human brain functions, to improve the generalisation ability of deep neural networks so that autonomous driving systems can perform well in various scenarios. Specifically, humans have a strong generalisation ability which is beneficial from the structural and functional asymmetry of the two sides of the brain. Here, we design dual Neural Circuit Policy (NCP) architectures in deep neural networks based on the asymmetry of human neural networks. Experimental results demonstrate that our brain-inspired method outperforms existing methods regarding generalisation when dealing with unseen data. Our source codes and pretrained models are available at https://github.com/Intenzo21/Brain-Inspired-Deep-Imitation-Learning-for-Autonomous-Driving-Systems.Keywords Brain-inspired AI • Imitation Learning • Autonomous Vehicles Successful deep neural networks with a single, task-specific algorithm should be able to generalise well across domains. Such an algorithm can enable simultaneous expression of generalisation ability by learning coherent representations and interpretable dynamics explanations of the world [8]. To some extent, deep neural networks, e.g., CNN, have shown generalisation ability on image classification, recognition [9] and autonomous driving/collision avoidance [10,11]