Jumping translocation of 17q11∼qter and 3q25∼q28 duplication in a variant Philadelphia t(9;14;22)(q34;q32;q11) in a childhood chronic myelogenous leukemia

Haltrich, Irén; Kost‐Alimova, Maria; Kovàcs, Gabór; Kriván, Gergely; Tamáska, Júlia; Klein, George; Fekete, György; Imreh, Stefan

doi:10.1016/j.cancergencyto.2005.06.019

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…The long arm of chromosome 1 (1q) is the most common donor chromosome in acquired JTs regardless of their hematologic diagnosis. [1][2][3] But neither the JT in CIMF nor the JT of 12q21 has been reported, this is the first report of JT involving 12q21 in a patient with CIMF. JT had not been consistently associated with a specific type of malignancy and appeared in the course of clonal karyotypic evolution with coexisting specific rearrangement, thus it seemed to be related to tumor progression rather than tumorigenesis.…”

Section: Discussionmentioning

confidence: 96%

“…Almost all of the telomeric regions can be involved as the recipients. [1][2][3] But in this case, the breakpoint of donor segment is not in heterochromatin region, so another mechanism is suspicious. We report here a first case of CIMF with JT involving 12q21.…”

Section: Discussionmentioning

confidence: 99%

“…Apparently balanced translocations between 5q and 12q were examined in 7 metaphases, and between 12p and 12q were examined in 3 metaphases. His karyotype was 46,XY,t(5;12)(q13;q21) [7]/46,XY,t(12; 12)(p13;q21) [3]/46,XY [10] (Fig. 3).…”

Section: Case Reportmentioning

confidence: 99%

“…The most commonly involved donor segment was long arm of chromosome 1 (1q), and the majority of cases were resulting in a partial trisomy or tetrasomy of 1q by unbalanced translocations. [1][2][3] We report here a case of chronic idiopathic myelofibrosis (CIMF) with JT of 12q21; t(5;12)(q13;q21) and t(12;12)(p13;q21) as the sole aberration. To our knowledge, this is the first report of JT in CIMF and involving 12q21.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Jumping Translocation of 12q21 in a Patient with Chronic Idiopathic Myelofibrosis

Cho

Hyun

2006

Korean J Hematol

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Jumping translocation (JT) has been defined as the translocation involving one donor chromosome and multiple recipient chromosomes in different cell lines in the same patient. This is rarely observed in various hematologic malignancies. Chronic idiopathic myelofibrosis (CIMF) is considered to be a clonal hematopoietic stem cell disorder, and clonal cytogenetic abnormalities have been reported to occur in about 30∼60% of patients. We report here on a case of CIMF with JT involving 12q21; t(5;12)(q13;q21) and t(12;12)(p13;q21) as the sole aberration. A pathogenetic relation between CIMF and the 12q rearrangement has been suggested in the literature, but neither the JT in CIMF nor the JT of 12q21 has been reported on. This is the first report of JT involving 12q21 in a patient with CIMF (ED note: nice writing).

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel Jumping Translocation of 12q21 in a Patient with Chronic Idiopathic Myelofibrosis

Cho

Hyun

2006

Korean J Hematol

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“…The most commonly detected donor chromosome segment is 1q (Berger & Bernard, ). Other donor chromosomes have been described, including chromosomes 3, 7, 9, 11 and 17 (Reis et al , ; Wlodarska et al , ; Najfeld et al , ; Fan et al , ; Haltrich et al , ). The recipient chromosome appears to be random.…”

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confidence: 99%

Jumping translocations, a novel finding in chronic lymphocytic leukaemia

et al. 2015

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Summary A jumping translocation (JT) is a rare cytogenetic aberration that can occur in haematological malignancy. It involves the translocation of the same fragment of donor chromosome onto two or more recipient chromosomes, typically in different cells. In this study, we describe the first series of chronic lymphocytic leukaemia (CLL) patients with JTs reported to date. Following a review of 878 CLL patient karyotypes, we identified 26 patients (3%) with 97 JTs. The most commonly occurring breakpoint in these translocations was 17p11.2. Loss of TP53 was identified prior to or at the same time as JT in 23 of 26 patients (88%). All patients eventually developed a complex karyotype. All but one patient has required treatment for CLL, with estimated median time to treatment of 11.5 months. This study establishes JTs as a recurrent abnormality found in CLL patients with aggressive disease. JTs contribute to complex karyotypes and, in many cases, are involved in chromosomal rearrangements that result in loss of the tumour suppressor gene TP53.

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Jumping translocations

Berger

Bernard

2007

Genes Chromosomes & Cancer

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Jumping translocations (JT) are uncommon constitutional or acquired chromosome rearrangements involving one donor and several recipient chromosomes. They occur in various pathologic conditions and the mechanism of their formation remains elusive. A review of the literature showed that the major localizations of the breakpoints of JTs in human samples are nonrandomly located in pericentromeric and telomeric regions of chromosomes. Interestingly, comparison of the localization of the chromosomal breakpoints and of presence of interstitial DNA repeats showed differences between constitutional and acquired JTs suggesting differences in the mechanisms for the genesis of JTs and their consequences.

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Jumping translocation of 17q11∼qter and 3q25∼q28 duplication in a variant Philadelphia t(9;14;22)(q34;q32;q11) in a childhood chronic myelogenous leukemia

Cited by 8 publications

References 27 publications

A Novel Jumping Translocation of 12q21 in a Patient with Chronic Idiopathic Myelofibrosis

A Novel Jumping Translocation of 12q21 in a Patient with Chronic Idiopathic Myelofibrosis

Jumping translocations, a novel finding in chronic lymphocytic leukaemia

Jumping translocations

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