Jumping the Barrier: Modeling Drug Penetration across the Blood–Brain Barrier

Abstract

Determining the penetration of drugs across the blood-brain barrier is a significant challenge in central nervous system drug development. The use of a mechanistic physiologically-based pharmacokinetic model can predict drug exposures in the brain without needing in situ drug measurements.

In silico tumor growth validation based on human brain cancer models

“…These models assume each organ or compartment as a complex sub-system and determine the detailed concentrations of drugs incorporate mechanistic understanding of the pharmacokinetic and pharmacodynamic behavior of a drug and its metabolites. Though PBPKs more roughly estimate the tumor's sufficient and necessary conditions, yet the available results consider critical aspects of the organism such as the BBB and /or renal excretion [143]. However, irrespectively of the mathematical approach, the biological data are necessary for all the computational models parameterization and validation in order to faithfully represent the biological processes.…”