Jumeaux et héritabilité des phénotypes dento-faciaux

Cohen-Lévy, Julia; Kamoun-Goldrat, Agnès; Simon, Yohann; Lautrou, Alain

doi:10.1051/orthodfr:2007004

Cited by 9 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The resulting embryos have identical genotypes and are prone to manifest the same phenotypic characteristics. However, epigenetic influences and environmental interactions can cause changes in the individuals' phenotypic pattern [11], [12]. In this context, the studies of twins may to help understanding the development of dentocraniofacial characteristics and determining the inheritance of malocclusions.…”

Section: Researchmentioning

confidence: 99%

Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

Gomes¹,

Souza²,

Gomes³

et al. 2020

JAMMR

View full text Add to dashboard Cite

Introduction: Monozygotic twins are a valuable sample for the study of human craniofacial growth and development. Aims: The aim of the present study was to analyze the dento-craniofacial characteristics in monozygotic twins and to discuss the genetic, epigenetic and environmental influences in the twin’s phenotypic features. Material and Methods: Two 21-year-old female twins attended the Dental Service of Universidade Federal dos Vales do Jequitinhonha e Mucuri were analyzed. For validation of this study, a genetic test of zygosity was performed to confirm the individuals' monozygosity. Intraoral buccal examination revealed occlusal differences as well as disagreement in the eruption of the third molars. Results: The analysis of models showed differences in the mesio-distal diameter of the teeth of both arches, as well as disagreement in the perimeter of the mandibular arches between the two individuals. The cephalometric analysis showed remarkable differences in the vertical and horizontal parameters of the craniofacial structure. The SNA, SNB and LAFH showed differences of 10º, 9º and 3mm respectively. Additionally, the components related to the dentition also showed discrepant results. Conclusion: It can be suggested that the dento-craniofacial characteristics present a genetic component; however, the interaction of epigenetic and environmental factors can lead to different phenotypes in univiteline twins.

show abstract

Section: Researchmentioning

confidence: 99%

Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

Gomes¹,

Souza²,

Gomes³

et al. 2020

JAMMR

View full text Add to dashboard Cite

show abstract

“…Studies on monozygotic twins may elucidate the genetics underlying the specific aspects of malocclusions and tooth anomalies in the analysis, improving the possibilities of performing a correct treatment plane [ 2 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Multiple Dental Inclusion in Monozygotic Twins with Congenital Visual Impairment

Galluccio

Impellizzeri

Stefano

et al. 2020

Case Reports in Dentistry

View full text Add to dashboard Cite

The study presents two monozygotic twins (MZ) with multiple impacted teeth, affecting the upper canines and lower second molars, as well as congenital aniridia. The clinical aspect of the upper canines is peculiar because of the different positions—palatal in one and buccal in the other twin. Studies reporting different scenarios of impaction in monozygotic twins can contribute more data to the debate on tooth eruption aetiology and more so in this case because of the association with a genetic panocular disease. Patients’ Concerns. The patients were referred by a general dentist, who diagnosed the presence of multiple inclusions. Diagnostic Study. Both patients showed severe malocclusion, classified as grade 5 of the Index of Orthodontic Treatment Need (IOTN). The MZ showed class I malocclusion, upper and lower crowding, and impacted lower right and left second molars. A Dentascan was prescribed for the canine impaction. The impaction of the upper canine was palatal of 2.3 in one of the MZ and buccal of 1.3 in the other one. The same altered pattern of eruption of the lower second molars was identified in both twins. The proposed treatment plan contemplated orthodontic surgical recovery of the impacted elements, followed by orthodontic treatment with multibracket appliance after the extraction of the first four premolars, given the crowding entity. The use of a retraction spring action was chosen for the recovery of the lower second molars. Many aspects of the possible genetic aetiology of tooth impaction are still under discussion. The study of diseases in twins offers decisive information. Finally, the possibility that alterations in the eruptive pattern of the dental elements may be associated with other congenital problems broadens the range of investigations related to the possible aetiological causes of the inclusions in humans.

show abstract

“…The fertilization of two oocytes creates dizygotic twins, and from the very beginning they develop as two different embryos, which have a similar genotype, so they are phenotypically similar to other siblings, which are not twins. Variations in dizygotic twins are mostly due to differences in genetic bases (5). Observing occlusal characteristics within families, Harris and Smith have concluded that most of the examined variables are under the influence of environmental factors, which is the consequence of the same living conditions within the family (6).…”

Section: Introductionmentioning

confidence: 99%

Heritability of Craniofacial Characteristics in Twins - Cephalometric Study

Tiro¹,

Dzemidzic²,

Salaga-Nefic³

et al. 2019

Med Arch

View full text Add to dashboard Cite

Introduction: The growth and development of the craniofacial complex are under the influence of genetic and environmental factors, which determine its morphological and functional characteristics. Twin studies provide significant insight into how many genetic and environmental factors determine dental and craniofacial characteristics. Aim: The aim of the study was to determine the genetic influence on craniofacial complex using a twin study model. Methods: The study sample comprised 52 pairs of twins who were referred to the Orthodontic Department, School of Dental medicine, University of Sarajevo. Informed consent was obtained by the parents of the children included in the study. Twenty pairs of twins were diagnosed as monozygotic while 32 pairs were diagnosed as dizygotic. Zygosity was diagnosed by physical characteristics similarity. Nineteen variables were measured: 10 dental variables, 9 cephalometric. Results: Based on the findings of this study, t-test showed significant genetic effect on the length of cranial base (p = 0.03), corpus of maxilla (p = 0.02) and mandibular length (p = 0.03), and also for B-angle (p = 0.04). Environmental factors are more involved in determining dental traits (e.g., the inclination of the incisors). Conclusion: There is a significant genetic effect on the linear cephalometric variables: the length of the cranial base, maxillary length and mandibular length.

show abstract

Jumeaux et héritabilité des phénotypes dento-faciaux

Cited by 9 publications

References 42 publications

Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

Multiple Dental Inclusion in Monozygotic Twins with Congenital Visual Impairment

Heritability of Craniofacial Characteristics in Twins - Cephalometric Study

Contact Info

Product

Resources

About