Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity

Jin, Baohua; Bai, Wanjun; Zhao, Jiaojiao; Xia, Qing; Han, Guohong; Li, Yahui; Hao, Jie; Chen, Siruan; Yang, Zhi‐Ling; Bai, Hua; Zhao, Zongmao; Jia, Qingzhong; Chen, Dong; Huang, Zhuo; Kong, Dezhi; Zhang, Wei

doi:10.1016/j.jep.2022.116048

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…Furthermore, its intracerebroventricular injection prevents sleep loss- induced memory impairment in APP/PS1 mice (36) and ameliorates cognitive impairment in Aβ42-injected mice by reducing the level of Aβ42 (37). Jujuboside B, when administered intraperitoneally, suppresses febrile seizure in lipopolysaccharide-injected mice (38). Oral administration of Spinosin improves the cognition of Aβ42 oligomer-injected mice (39) and in adult mice increasing neurogenesis as well as the levels of BDNF (40).…”

Section: Discussionmentioning

confidence: 99%

“…The major ingredients of ZSS are jujuboside A, jujuboside B, and spinosin (32)(33)(34), all of which have been reported to possess neuroprotective effects (35)(36)(37)(38)(39)(40)(41). We speculated that ZSS simple crush powder has stronger effects than the hot water extract because the powder contains higher amounts of these components than the extract.…”

Section: Analysis Of the Three Components Of Zss Preparations And The...mentioning

confidence: 99%

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Simply crushedZizyphi spinosi semenprevents neurodegenerative diseases and reverses age-related cognitive decline in mice

Umeda,

Sakai,

Uekado

et al. 2024

Preprint

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Neurodegenerative diseases are age-related disorders characterized by the cerebral accumulation of amyloidogenic proteins, and cellular senescence underlies their pathogenesis. Thus, it is necessary for preventing these diseases to remove toxic proteins, repair damaged neurons, and suppress cellular senescence. As a source for such prophylactic agents, we selectedZizyphi spinosi semen(ZSS), a medicinal herb used in traditional Chinese medicine. ZSS hot water extract ameliorated Aβ and tau pathology and cognitive impairment in mouse models of Alzheimer’s disease and frontotemporal dementia. Non-extracted ZSS simple crush powder showed stronger effects than the extract and improved α-synuclein pathology and cognitive/motor function in Parkinson’s disease model mice. Furthermore, when administered to normal aged mice, the ZSS powder suppressed cellular senescence, reduced DNA oxidation, promoted brain-derived neurotrophic factor expression and neurogenesis, and enhanced cognition to levels similar to those in young mice. The quantity of known active ingredients of ZSS, jujuboside A, jujuboside B, and spinosin, was not proportional to the nootropic activity of ZSS. These results suggest that ZSS simple crush powder is a promising dietary material for the prevention of neurodegenerative diseases and brain aging.Impact statementNon-extracted simple crush powder ofZizyphi spinosi semenhas not only disease-preventing effects but also brain-rejuvenating effects in mice.

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Section: Discussionmentioning

confidence: 99%

Section: Analysis Of the Three Components Of Zss Preparations And The...mentioning

confidence: 99%

Simply crushedZizyphi spinosi semenprevents neurodegenerative diseases and reverses age-related cognitive decline in mice

Umeda,

Sakai,

Uekado

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Similarly, Panpan Song et al reported that jujuboside B (jub B) also leads to an increase of the GABA as well as overexpression of GABAAR, which plays a critical role in the control of seizures. A febrile seizure is a non-epileptic seizure affecting children between 3 months and 5 years, and phytotherapeutic treatment could also help in the control of this seizure by targeting the excitatory pathway of the CNS (Song et al, 2017;Jin et al, 2023 hypothesized and then proved that jujuboside can modulate the excitatory pathway by inhibiting the glutamate receptor AMPA and could be used as a potent agent against febrile seizure (Jin et al, 2023). In this study, they used EEG recording for the monitoring of current in the mouse model of febrile seizure and to evaluate the efficacy of the Jub B as shown in Figure 3A.…”

Section: Modulation Of Excitatory Pathwaymentioning

confidence: 99%

“…FIGURE 3Phytochemicals can modulate NMDAR and AMPAR in the animal model of epilepsy. (A) Mechanistic overview of the effect of Jujuboside B from medicinal plants against febrile seizures and the mechanism of action on AMPA receptor(Jin et al, 2023). Copyright permission@ Elsevier 2023.…”

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confidence: 99%

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Waris,

Ullah,

Asim

et al. 2024

Front. Pharmacol.

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Epilepsy is one of the most common, severe, chronic, potentially life-shortening neurological disorders, characterized by a persisting predisposition to generate seizures. It affects more than 60 million individuals globally, which is one of the major burdens in seizure-related mortality, comorbidities, disabilities, and cost. Different treatment options have been used for the management of epilepsy. More than 30 drugs have been approved by the US FDA against epilepsy. However, one-quarter of epileptic individuals still show resistance to the current medications. About 90% of individuals in low and middle-income countries do not have access to the current medication. In these countries, plant extracts have been used to treat various diseases, including epilepsy. These medicinal plants have high therapeutic value and contain valuable phytochemicals with diverse biomedical applications. Epilepsy is a multifactorial disease, and therefore, multitarget approaches such as plant extracts or extracted phytochemicals are needed, which can target multiple pathways. Numerous plant extracts and phytochemicals have been shown to treat epilepsy in various animal models by targeting various receptors, enzymes, and metabolic pathways. These extracts and phytochemicals could be used for the treatment of epilepsy in humans in the future; however, further research is needed to study the exact mechanism of action, toxicity, and dosage to reduce their side effects. In this narrative review, we comprehensively summarized the extracts of various plant species and purified phytochemicals isolated from plants, their targets and mechanism of action, and dosage used in various animal models against epilepsy.

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“…Numerous in vivo and in vitro studies (Ho et al, 2014;Jia et al, 2018;Hu et al, 2019;Jin et al, 2023) have shown that CHM can exert neuroprotective effects by regulating central neurotransmitters (Gao et al, 2016;Jin et al, 2019;Deng et al, 2020), inhibiting apoptosis (Yang et al, 2020), regulating oxidative stress, and inhibiting inflammatory response (Xia et al, 2021), thereby improve electroencephalographic activity, and effectively controlling seizure rates. At the same time, it also can alleviate AEs caused by CWM and improve patients' quality of life.…”

Section: Implications For Researchmentioning

confidence: 99%

Efficacy and safety of Chinese herbal medicine in post-stroke epilepsy: a systematic review and meta-analysis

Sun,

Wang,

et al. 2023

Front. Pharmacol.

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Background: Poststroke epilepsy (PSE) is a common complication of strokes that seriously affects the recovery and quality of life of patients, and effective treatments are needed. Chinese herbal medicine (CHM) adjunctive therapy is a viable treatment option, but current evidence is insufficient to support its efficacy and safety. This study aimed to evaluate the efficacy and tolerability of CHM adjunctive therapy in the treatment of PSE.Methods: A systematic search of eight databases was conducted to identify PSE-related randomized clinical trials from the inception of each database through October 2023. The methodological quality assessment was conducted by RoB 2.0, meta-analysis was conducted by RevMan 5.3 and Stata 15.1, and evidence quality was evaluated by GRADE.Results: Twenty-three RCTs involving 1,901 PSE patients were identified. We found that orally administered CHM plus conventional Western medicine (CWM) was superior to CWM monotherapy in increasing the 75% responder rate (RR 1.46, 95% CI: 1.31 to 1.62, p < 0.00001), decreasing the seizure duration (MD -1.01, 95% CI: −1.30 to −0.72, p < 0.00001), improving total responder rate (RR 1.29, 95% CI: 1.20 to 1.37, p < 0.00001), reducing epileptiform discharges (EDs) (MD -2.02.46, 95% CI: −2.64 to −1.40, p < 0.00001), and decreasing the number of leads involved in epileptiform discharge (MD -3.92, 95% CI: −5.15 to −2.68, p < 0.00001). Furthermore, intravenously administered CHM plus CWM was superior regarding 75% responder rate (RR 1.39, 95% CI: 1.24 to 1.56, p < 0.00001), total responder rate (RR 1.29, 95% CI: 1.20 to 1.39, p < 0.00001), EDs (MD -3.92, 95% CI: −5.15 to −2.68, p < 0.00001), and the number of leads involved in epileptiform discharge (MD -1.82, 95% CI: −2.62 to −1.02, p < 0.00001). However, regarding the 50%–75% responder rate, there was no statistically significant difference between the two groups for either oral (RR 1.00, 95% CI: 0.77 to 1.29, p = 0.98) or injectable CHM (RR 0.95, 95% CI: 0.67 to 1.33, p = 0.75). Both orally administered CHM plus CWM (RR 0.56, 95% CI: 0.35 to 0.90, p = 0.02) and intravenously administered CHM plus CWM (RR 0.64, 95% CI: 0.45 to 0.90, p = 0.010) caused fewer AEs than CWM. Furthermore, the levels of evidence ranged from low to high due to publication bias and heterogeneity.Conclusion: CHM adjuvant therapy may be an effective and safe therapy for PSE. However, due to the poor quality of clinical data, more well-designed RCTs are needed to confirm these findings.Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364356, identifier PROSPERO (CRD42022364356)

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Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity

Cited by 5 publications

References 39 publications

Simply crushedZizyphi spinosi semenprevents neurodegenerative diseases and reverses age-related cognitive decline in mice

Simply crushedZizyphi spinosi semenprevents neurodegenerative diseases and reverses age-related cognitive decline in mice

Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action

Efficacy and safety of Chinese herbal medicine in post-stroke epilepsy: a systematic review and meta-analysis

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