Jugular venous flow dynamics during acute weightlessness

Marshall-Goebel, Karina; Lee, Stuart M. C.; Lytle, Jason R.; Martin, David S.; Miller, Christopher A.; Young, Millennia; Laurie, Steven S.; Macias, Brandon R.

doi:10.1152/japplphysiol.00384.2023

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Our simulations indicated an increase in right atrial pressure upon exposure to microgravity. Raised venous pressure has been associated with venous endothelial damage (Castro-Ferreira et al, 2018), which, in turn, is a risk factor for thrombosis development (Marshall-Goebel et al, 1985;Anderson and Spencer, 2003). This suggests a potential link between increased venous pressure, endothelial damage, and the occurrence of internal jugular vein thrombosis in astronauts.…”

Section: Implications For Internal Jugular Vein Thrombosismentioning

confidence: 99%

Computational modeling of heart failure in microgravity transitions

Wilson,

Schulte,

Steins

et al. 2024

Front. Physiol.

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The space tourism industry is growing due to advances in rocket technology. Privatised space travel exposes non-professional astronauts with health profiles comprising underlying conditions to microgravity. Prior research has typically focused on the effects of microgravity on human physiology in healthy astronauts, and little is known how the effects of microgravity may play out in the pathophysiology of underlying medical conditions, such as heart failure. This study used an established, controlled lumped mathematical model of the cardiopulmonary system to simulate the effects of entry into microgravity in the setting of heart failure with both, reduced and preserved ejection fraction. We find that exposure to microgravity eventuates an increased cardiac output, and in patients with heart failure there is an unwanted increase in left atrial pressure, indicating an elevated risk for development of pulmonary oedema. This model gives insight into the risks of space flight for people with heart failure, and the impact this may have on mission success in space tourism.

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Section: Implications For Internal Jugular Vein Thrombosismentioning

confidence: 99%

Computational modeling of heart failure in microgravity transitions

Wilson,

Schulte,

Steins

et al. 2024

Front. Physiol.

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Characterization of internal jugular vein region-specific distension and flow patterns during progressive volume shifting

Cohen,

Hedge,

Greaves

et al. 2024

Journal of Applied Physiology

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Blood volume shifts during postural adjustment leads to irregular distension of the internal jugular vein (IJV). In microgravity, distension may contribute to flow stasis and thromboembolism, though the regional implications and associated risk remain unexplored. We characterized regional differences in IJV volume distension and flow complexity during progressive head-down tilt (HDT) (0°, -6°, -15°, -30°) using conventional ultrasound and vector flow imaging. We also evaluated low-pressure thigh cuffs (40 mmHg) as a fluid shifting countermeasure during -6° HDT. Total IJV volume expanded 139±95% from supine (4.6±2.7 mL) to -30° HDT (10.3±5.0 mL). Blood flow profiles had greater vector uniformity at the cranial IJV region (P<0.01) and became more dispersed with increasing tilt (P<0.01). Qualitatively, flow was more uniform throughout the IJV during its early flow cycle phase, and more disorganized during late flow phase. This disorganized flow was accentuated closer to the vessel wall, near the caudal region, and during greater HDT. Low-pressure thigh cuffs during -6° HDT decreased IJV volume at the cranial region (-12±15%; P<0.01) but not the caudal region (P=0.20), although flow uniformity was unchanged (both regions,P>0.25). We describe a distensible IJV accommodating large volume shifts along its length. Prominent flow dispersion was primarily found at the caudal region, suggesting multi-directional blood flow. Thigh cuffs appear effective for decreasing IJV volume but effects on flow complexity are minor. Flow complexity along the vessel length is likely related to IJV distension during chronic volume shifting and may be a precipitating factor for flow stasis and future thromboembolism risk.

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Jugular venous flow dynamics during acute weightlessness

Cited by 2 publications

References 38 publications

Computational modeling of heart failure in microgravity transitions

Computational modeling of heart failure in microgravity transitions

Characterization of internal jugular vein region-specific distension and flow patterns during progressive volume shifting

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