Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats

Peng, Xiaohui; Nie, Yao; Wu, Jianjun; Huang, Qiang; Cheng, Yuqiang

doi:10.1016/j.bbrc.2015.04.124

Cited by 41 publications

(26 citation statements)

References 28 publications

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“…In 2007, we found that changes in gut microbiota composition observed following HFD feeding were associated with increased plasma lipopolysaccharide (LPS) levels (the so‐called metabolic endotoxemia) , a phenomenon also extensively confirmed in other studies and in humans (Fig. ) , except in a recent study . The reason of this discrepancy is likely due to the difficulty to asses these critical parameters in complex matrix such as blood (e.g., false negative and LPS recoveries).…”

Section: Introductionmentioning

confidence: 69%

Talking microbes: When gut bacteria interact with diet and host organs

Cani

Everard

2015

Molecular Nutrition Food Res

125

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Obesity and diabetes have reached epidemic proportions. Evidence suggests that besides dietary habits and physical activity, other environmental factors, such as gut microbes, are recognized as additional partners implicated in the control of energy homeostasis. Studies on the human gut microbiota have shown that the general population can be stratified on the sole basis of three dominant bacteria (i.e., the concept of enterotypes), while some others have suggested categorizing the population according to their microbiome gene richness. Both aspects have been strengthened by recent studies investigating the impact of nutrients (e.g., dietary fibers, fat feeding) and dietary habits (i.e., vegans versus omnivores) of different populations. Using preclinical models, quite a few novel mechanisms have been proposed in these gut microbiota–host interactions, including the role of novel bacteria, the regulation of antimicrobial peptide production, the maintenance of the gut barrier function and intestinal innate immunity. In this review, we discuss several of the aforementioned aspects. Nonetheless, determining the overall mechanisms by which microbes dialogue with host cells will require further investigations before anticipating the development of next‐generation nutritional interventions using prebiotics, probiotics, synbiotics, or even specific nutrients for promoting health benefits.

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Section: Introductionmentioning

confidence: 69%

Talking microbes: When gut bacteria interact with diet and host organs

Cani

Everard

2015

Molecular Nutrition Food Res

125

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“…[29] Inflammatory cytokines promote growth in cancer cells and support their survival by interacting with signaling molecules. [32,33] Therefore, the aim of the study was to elucidate the roles of Wnt, Notch, and PPARγ pathways in colon carcinogenesis. [32,33] Therefore, the aim of the study was to elucidate the roles of Wnt, Notch, and PPARγ pathways in colon carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells

Seetha

Devaraj

Sudhandiran

2020

J Biochem & Molecular Tox

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Colorectal cancer (CRC) is the third most common fatal cancer. Indomethacin, a nonsteroidal anti-inflammatory drug, is known to reduce the occurrence of CRC.This study evaluated the potential anticolon cancer effects of juglone (5-hydroxy-1,4-naphthoquinone) in combination with indomethacin. Human colon adenocarcinoma cells (HT29) were subjected to treatment with indomethacin, juglone, and a combination of both. Morphological analysis, cell cycle regulation, and dual staining using acridine orange and ethidium bromide in control and treated cells revealed the apoptotic potential of these compounds. Bcl2 and inflammatory molecules (tumor necrosis factor-α, nuclear factor kappa B, and Cox-2) were found to be decreased with a concomitant increase in the expression of proapoptotic molecules (Bad, Bax, cytochrome c, and PUMA) as a result of the molecular regulation of Wnt, Notch, and peroxisome proliferator-activated receptor-γ signaling. Treatment with juglone was not as effective as with indomethacin; however, a combination of both was shown to be more effective, suggesting that juglone may be considered for therapeutic intervention of colon cancer.

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“…We reported that the siRNA against Pin1 inhibited differentiation of NIH3T3-L1 cells and the inhibitory effect of Pin1 depletion was further confirmed by using two known Pin1 inhibitors, juglone and PiB (diethyl- 1,3,6,8- tetrahydro- 1,3,6,8- tetraoxobenzol—phenanthroline- 2,7-diacetate) (7). Recently it was reported that oral administration of juglone, a Pin1 inhibitor, with high-fat diet in rats suppressed gaining weights [17], which suggests that brown algae polyphenol suppressed gaining weights as a result of inhibiting Pin1. In this report, we showed that brown algae polyphenol suppresses differentiation of stem cells into adipocytes by using the ASC lines that are much the same as natural preadipocytes.…”

Section: Discussionmentioning

confidence: 99%

Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes

et al. 2016

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BackgroundWhile screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes. However, its effectiveness on the accumulation of fat in the body has never been studied.Methodology/Principal FindingsOral administration of brown algae polyphenol to mice fed with a high fat diet, suppressed the increase in fat volume to a level observed in mice fed with a normal diet. We speculate that Pin1 might be required for the differentiation of stem cell to adipocytes. We established wild type (WT) and Pin1-/- (Pin1-KO) adipose-derived mesenchymal stem cell (ASC) lines and found that WT ASCs differentiate to adipocytes but Pin1-KO ASCs do not.Conclusion and SignificanceOral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice. We showed that Pin1 is required for the differentiation of stem cells into adipocytes. We propose that oral intake of brown algae polyphenol is useful for the treatment of obesity.

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Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats

Cited by 41 publications

References 28 publications

Talking microbes: When gut bacteria interact with diet and host organs

Talking microbes: When gut bacteria interact with diet and host organs

Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells

Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes

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