Juglanones A and B: Two Novel Tetralone Dimers from Walnut Pericarp (<i>Juglans regia</i>)

Li, Congying; Du, Hongjian; Su, Xue‐Hui; Zhong, Yu‐Jiao; Yuan, Zhi‐Peng; Li, Yanfang; Liang, Bing

doi:10.1002/hlca.201200525

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…pericarps, green husks, stem-bark, branches, etc.) (Du et al, 2014;Li et al, 2013Li et al, , 2008aLiu et al, 2010;Talapatra et al, 1988;Wang et al, 2017). Particularly, the tetralone derivatives found in green husks of J. regia usually occur as hydroxyl, hexosyl and hydroxybenzoyl derivatives, with several isomeric alternatives (Zhou et al, 2015).…”

Section: Phytochemical Composition Of Walnut Husksmentioning

confidence: 99%

“…The authors also presented results about the regiolone toxicity against HeLa (30.48 μM) and HL-60 (40.21 μM) cell cultures. Furthermore, two tetralone dimers (juglanone A and B) were isolated from J. regia pericarps (husks) by Li et al (2013). The cytotoxicity of the pure compounds was assessed against a series of human cell lines (A549, HeLa,COLO205,.…”

Section: Bioactivity Of the Hydroethanolic Extractsmentioning

confidence: 99%

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Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals

Vieira

Pereira

Abreu

et al. 2020

Food and Chemical Toxicology

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Juglans regia L. (walnut) green husks are an important fraction of waste resulting from the walnut production, thus representing an interesting natural matrix to explore as a source of bioactive compounds. In this work, the hydroethanolic extract of walnut green husks was studied considering the phytochemical composition and the biological activity using different cell model assays, most of them evaluated for the first time for this matrix. From the HPLC-DAD-ESI/MS n analysis, sixteen compounds were identified, being the extract mostly composed of naphthalene derivatives (including tetralone derivatives) and less abundant in phenolic compounds (hydroxycinnamic acids and flavonols). The cytotoxic potential of the extract was assessed against tumour (MCF-7, NCI-H460, HeLa and HepG2) and non-tumour (PLP2) cell lines. Moreover, the antioxidant activity of the extract was evaluated by inhibition of the oxidative haemolysis (OxHLIA) and the formation of thiobarbituric acid reactive substances (TBARS), and the anti-inflammatory potential by the inhibition of the NO production by the RAW264.7 cell culture. The antibacterial effects of the extract were also evaluated against Gram-negative and Gram-positive bacteria. The results obtained represent a stepping stone for the development of future applications using walnut green husks as a source of added value compounds with bioactive potential.

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Section: Phytochemical Composition Of Walnut Husksmentioning

confidence: 99%

Section: Bioactivity Of the Hydroethanolic Extractsmentioning

confidence: 99%

Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals

Vieira

Pereira

Abreu

et al. 2020

Food and Chemical Toxicology

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“…Sclerone was identified in the green husk extract of the Persian walnut when a rapid capillary zone electrophoresis method for the simultaneous determination of four cyclic diarylheptanoids and a tetralone derivative was developed [146]. Li et al described the isolation of juglanones A and B as tetralone dimers with an O-bridge from the extract of the walnut husk [145]. These compounds were the first examples of O-bridged dimeric tetralones.…”

Section: Chemical Constituents Of Walnut Huskmentioning

confidence: 99%

“…To find new antitumor agents from natural products, juglanones A and B have been isolated as two new tetralone dimers from J. regia L; then, seven different human cancer cell lines (A549, MCF-7, BEL-7402, HeLa, COLO205, BGC-823, and SKOV3) have been evaluated for cytotoxic effects of the isolated compounds. The IC 50 values for the considered cell lines have been reported in the range of 0.26 to 1.67 μM [145].…”

Section: Walnut Husk Usesmentioning

confidence: 99%

A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut (Juglans spp.) Husk

Jahanban-Esfahlan

Ostadrahimi

Tabibiazar

et al. 2019

IJMS

150

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The walnut (Juglans spp.) is an appreciated nut that belongs to the Juglandaceae family. The fruit includes four main parts: the kernel, the skin, the shell, and the green husk. It is widely cultivated due to its edible kernel. In walnut production centers, high amounts of the husk as an agro-forest waste product are produced and discarded away. Recently, it has been demonstrated that the walnut green husk could be valued as a source of different natural bioactive compounds with excellent antioxidant and antimicrobial properties. Regarding this respect, in this contribution, the current scientific knowledge on the antioxidant and antiradical activities, various identified and isolated individual chemical constituents, as well as the functional applications of the walnut husk with more emphasis on the Persian walnut (Juglans regia L.) are reviewed.

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“…Traditionally in Europe the leaves of the species have been used to relief the minor inflammatory skin conditions, while in Chinese traditional medicine the green pericarps have been used for their anticancer and antioxidant properties, as well as for treating pain, inflammation and skin diseases . The species of Juglandaceae family are characterized by a plethora of secondary metabolites, with tetralones, naphthoquinones and diarylheptanoids being useful chemotaxonomic markers within Juglandaceae genera . So far, literature data give information only on the chemical profile of the Juglandaceae taxa growing in Asia .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Study of Juglans regia L. Pericarps from Greece with a Chemotaxonomic Approach

Tsasi

Milošević-Ifantis

Skaltsa

2016

Chemistry & Biodiversity

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Phytochemical research of different polarity extracts from green Juglans regia L. pericarps from Greece afforded 32 compounds: four pentacyclic triterpenes (1 - 4), three sesquiterpenes (5 - 7), four tetralones (8 - 11), two naphthoquinones (12 and 13), seven phenolic acids (14 - 20), one diarylheptanoid (21), one neo-lignan (22), seven flavonoids (23 - 29), two phenylethanoids (30 and 31) and one hydrolysed tannin (32). Compounds 4 and 29 are isolated for the first time from the species, while compounds 3, 7, 20, 22, 23, 24, 25, 26, 28, 30 are reported for the first time in Juglandaceae. Chemotaxonomic significance of isolated compounds into Junglandaceae family is thoroughly discussed.

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Juglanones A and B: Two Novel Tetralone Dimers from Walnut Pericarp (Juglans regia)

Cited by 9 publications

References 13 publications

Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals

Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals

A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut (Juglans spp.) Husk

Phytochemical Study of Juglans regia L. Pericarps from Greece with a Chemotaxonomic Approach

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