Judith: Defender of Israel – Preserver of the Temple

Christiansen, Ellen Juhl

doi:10.1515/9783110279986.70

Cited by 23 publications

(2 citation statements)

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“…Three other PKC isoenzymes, 6, E and [, lack Ca2+ sensitivity. PKC is abundantly present in neutrophils compared to other tissues and has been purified to homogeneity by different methods (Christiansen and Juhl, 1986;Dianoux et al, 1989). Human neutrophils contain the M. and p isoforms of PKC with a large predominance of the M form (Pontremoli et al, 1990;Majumdar et al, 1991), whereas PKC of bovine neutrophils consists of a predominant P isoform and a minor one identified as [ PKC .…”

Section: The Early Steps In the Signaling Pathwaymentioning

confidence: 99%

“…In fact, when neutrophils are challenged by an agonist, PKC is translocated to the membrane. This translocation occurs within seconds and precedes the respiratory burst (Wolfson, 1985;Christiansen, 1988). A detailed analysis of PKC translocation in activated neutrophils has revealed that, besides the classical PPKC isoform which is translocatable, there is a Ca2 +-independent, phosphatidylserinedependent and diacylglycerol-dependent PKC form, termed nPKC, which is not translocated to the membrane upon activation (Majumdar et al, 1991).…”

Section: The Early Steps In the Signaling Pathwaymentioning

confidence: 99%

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The superoxide‐generating oxidase of phagocytic cells

Morel¹,

Doussière²,

Vignais³

1991

European Journal of Biochemistry

536

260

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Professional phagocytes (neutrophils, eosinophils, monocytes and macrophages) possess an enzymatic complex, the NADPH oxidase, which is able to catalyze the one-electron reduction of molecular oxygen to superoxide, 0;. The NADPH oxidase is dormant in non-activated phagocytes. It is suddenly activated upon exposure of phagocytes to the appropriate stimuli and thereby contributes to the microbicidal activity of these cells. Oxidase activation in phagocytes involves the assembly, in the plasma membrane, of membrane-bound and cytosolic components of the oxidase complex, which were disassembled in the resting state. One of the membrane-bound components in resting phagocytes has been identified as a low-potential b-type cytochrome, a heterodimer composed of two subunits of 22-kDa and 91-kDa. The link between NADPH and cytochrome b is probably a flavoprotein whose subcellular localization in resting phagocytes remains to be determined. Genetic defects in the cytochrome b subunits and in the cytosolic factors have been shown to be the molecular basis of chronic granulomatous disease, a group of inherited disorders in the host defense, characterized by severe, recurrent bacterial and fungal infections in which phagocytic cells fail to generate 0 , upon stimulation. The present review is focused on recent data concerning the signaling pathway which leads to oxidase activation, including specific receptors, the production of second messengers, the organization of the oxidase complex and the molecular defects responsible for granulomatous disease.

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Section: The Early Steps In the Signaling Pathwaymentioning

confidence: 99%

Section: The Early Steps In the Signaling Pathwaymentioning

confidence: 99%

The superoxide‐generating oxidase of phagocytic cells

Morel¹,

Doussière²,

Vignais³

1991

European Journal of Biochemistry

536

260

View full text Add to dashboard Cite

show abstract

The Idea of Israel in Second Temple Judaism

Staples

2021

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In this book, Jason A. Staples proposes a new paradigm for how the biblical concept of Israel developed in Early Judaism and how that concept impacted Jewish apocalyptic hopes for restoration after the Babylonian Exile. Challenging conventional assumptions about Israelite identity in antiquity, his argument is based on a close analysis of a vast corpus of biblical and other early Jewish literature and material evidence. Staples demonstrates that continued aspirations for Israel's restoration in the context of diaspora and imperial domination remained central to Jewish conceptions of Israelite identity throughout the final centuries before Christianity and even into the early part of the Common Era. He also shows that Israelite identity was more diverse in antiquity than is typically appreciated in modern scholarship. His book lays the groundwork for a better understanding of the so-called 'parting of the ways' between Judaism and Christianity and how earliest Christianity itself grew out of hopes for Israel's restoration.

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Preface

2021

The Idea of Israel in Second Temple Judaism

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Judith: Defender of Israel – Preserver of the Temple

Cited by 23 publications

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The superoxide‐generating oxidase of phagocytic cells

The superoxide‐generating oxidase of phagocytic cells

The Idea of Israel in Second Temple Judaism

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