Judgment of Color Doppler Ultrasound with Respect to Cavernous Artery Occlusion Pressure in Dynamic Infusion Cavernosometry When Evaluating Arteriogenic Impotence

Abstract

This prospective study was designed to compare the parameters obtained by color Doppler ultrasound to cavernous artery occlusion pressure measured by dynamic pharmacoinfusion cavernosometry in evaluating arterial components of erectile dysfunction. Four indexes were determined as parameters of sonography to indicate arterial competence. Indexes 1 and 2 reflected peak systolic velocities with respect to the cut-off values 25 and 30 cm/s after pharmacological stimulation with 60 mg papaverine hydrochloride respectively. Index 3 was the percentage of diameter changes in cavemosal arteries which was expected to be > 75%. The sum of the percents of increases in diameters of both cavemosal arteries which should be > 200, formed index 4. The sensitivity, specificity, positive predictive value and accuracy rates were 76, 100, 100 and 90% for index 2. These values were 50, 100, 100 and 71% for index 1. Very low statistical values were obtained for indexes 3 and 4. Although the gold standard in the diagnosis of arterial impotence is pharmacoangiography, color Doppler sonography using the parameter peak systolic flow rate > 30 cm/s may be a reliable, easily obtained, noninvasive technique for evaluating arterial components of erectile dysfunction.

Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats

“…With normal erectile function, a high intracavernous pressure (ICP) is maintained with a low inflow rate. 2 Patients with venoocclusive dysfunction (venous leakage) exhibit a poor response to intracavernous injection with vasoactive agents (papavarine, prostaglandin E1, phentolamine, or combinations, for example), despite good arterial flow demonstrated by duplex ultrasound.…”

“…The objectives of this study were (1) to establish normal values for pharmacologic cavernosometry in the rat and validate a rat model of venogenic ED (Experiment 1: Model validation), (2) to prevent venogenic ED (Experiment 2: Prevention trial), and (3) to reverse venogenic ED (Experiment 3: Treatment trial). Since the cavernosal sinusoids are lined with numerous endothelial cells, the target cell type of VEGF, the penis is an ideal organ for VEGF therapy.…”

Duplex ultrasound evaluation of cavernosal peak systolic velocity and waveform acceleration in the penile flaccid state: clinical significance in the assessment of the arterial supply in patients with erectile dysfunction

“…The echo colour Doppler assessment of cavernosal arteries is considered a reliable tool for the evaluation of penile arterial patency. A PGE1 induced cavernosal peak systolic flow ≥25–30 cm/sec is usually considered normal ( Lue et al ., 1985 ; Quam et al ., 1989 ; Chiang et al ., 1991 ; Pickard et al ., 1991 ; Benson et al ., 1993 ; Lee et al ., 1993 ; Karadeniz et al ., 1996 ). We previously reported that, in a group of 63 unselected men with erectile dysfunction, the PGE1 induced cavernosal blood flow peak systolic velocity (PSV) was significantly related both to the basal cavernosal PSV and the erectile response ( Mancini et al ., 1996 ).…”

Congruence between veno-occlusive parameters during dynamic infusion cavernosometry: assessing the need for cavernosography

“…While most centers are currently using duplex Doppler penile ultrasonography. [1][2][3][4] as their vascular evaluation of choice, the previously widely used study, dynamic infusion cavernosometry (DIC), is still used by some centers, [5][6][7][8][9][10] including ours.…”