JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits significant anti-inflammatory effect while maintaining bone mineral density in mice
“…This model formed the basis for extensive attempts to develop improved GR ligands with reduced side effects ( 80 ), none of which have resulted in clinically used drugs. As we will discuss below, although it is increasingly recognized that the bifurcated model is overly simplistic, the model continues to be incorporated in currently and serves as a conceptual framework for understanding GR signaling ( 81 , 82 , 83 , 84 , 85 ). Figure 2 A classical model of GR-mediated inflammatory repression.…”
Section: Classical Models Of Gr Signalingmentioning
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
“…This model formed the basis for extensive attempts to develop improved GR ligands with reduced side effects ( 80 ), none of which have resulted in clinically used drugs. As we will discuss below, although it is increasingly recognized that the bifurcated model is overly simplistic, the model continues to be incorporated in currently and serves as a conceptual framework for understanding GR signaling ( 81 , 82 , 83 , 84 , 85 ). Figure 2 A classical model of GR-mediated inflammatory repression.…”
Section: Classical Models Of Gr Signalingmentioning
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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