Jowl Reduction With Deoxycholic Acid

Abstract

BACKGROUND The study proposes a novel protocol for targeting the jowls using deoxycholic acid (DCA) injections, with emphasis on safety and feasibility of the procedure. METHODS This prospective study was conducted at a cosmetic practice between June 2016 and May 2017. Twelve consecutive patients seeking reduction/improvement in mild/moderate jowl fat were injected with DCA subcutaneously in a predefined circular area 1.0 cm above the mandibular border. Treatment response was assessed using physician-evaluated Global Aesthetic Improvement Scale (GAIS) and Subject GAIS. RESULTS Twelve patients (11 women and 1 man) with mild (n = 8) or moderate (n = 4) jowls were treated. After the first treatment, GAIS responses for 24 jowls showed 5 jowls with vast improvement, 15 with moderate improvement, and 4 with no change. After the second session for 5 jowls in 3 patients, GAIS responses showed vast improvement in 4 jowls and moderate improvement in 1. Adverse events included induration (n = 4), bruising (n = 6), numbness (n = 2), pain (n = 5), redness (n = 3), edema (n = 9), and dysphagia (n = 1). CONCLUSION Results of this early experience showed that DCA injections were safe and effective for nonsurgical jowl reduction.

Best Clinical Practices with ATX-101 for Submental Fat Reduction: Patient-related Factors and Physician Considerations

“…Packaging ATX-101 treatments as outcome-based treatments may improve compliance with the multiple treatment cycles required for optimal results. Following the approval of ATX-101 for SMF reduction, successful off-label use of ATX-101 has been reported for reduction of excess subcutaneous fat in other areas such as jowl fat 18 , 27 , 28 and bra (peri- and post-axillary) fat. 29 The clinical practices outlined in this article will help physicians improve the treatment experience of patients seeking to address their SMF and rejuvenate their lower face.…”

Nonsurgical fat reduction: Cryolipolysis, RF skin tightening, HIFEM, and injectable lipolysis

“…Montes et al 49 regarding a novel protocol for targeting jowls with DCA injections and safety emphasis of the procedure. The study was conducted between June 2016 and May 2017 in a cosmetic practice on 12 patients seeking improvement of mild to moderate jowl fat.…”

“…DCA was injected in a circular area 1.0 cm above the mandibular border. 49 The Global Aesthetic Improvement Scale (GAIS) and subject GAIS treatment was used to assess the subjects. After the first treatment, 24 jowls showed five jowls with vast improvement, 15 with moderate improvement, and 4 no change.…”

“…After a second session, five jowls in three patients, GAIS showed vast improvement in four jowls and moderate improvement in one subject. 49 Adverse events included bruising, induration, numbness, pain, redness, edema, and dysphagia. Montes et al 49 conclude the off-label early experience study showed that DCA improves nonsurgical jowl reduction as a safe and effective treatment.…”

“…49 Adverse events included bruising, induration, numbness, pain, redness, edema, and dysphagia. Montes et al 49 conclude the off-label early experience study showed that DCA improves nonsurgical jowl reduction as a safe and effective treatment. Belkyra in Australia, Canada, Europe, and South Korea; Kythera Biopharmaceuticals, Inc., an affiliate of Allergan).…”