Journey of organ on a chip technology and its role in future healthcare scenario

Singh, D. B.; Mathur, Ashish; Arora, Smriti; Roy, Souradeep; Mahindroo, Neeraj

doi:10.1016/j.apsadv.2022.100246

Cited by 39 publications

(24 citation statements)

References 100 publications

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“…[313,314] In essence, OoC refers to a single-channel or multichannel 3D chip of a microfluidic cell culture simulating organ-level or tissue-level physiology, categorized into hydrogelbased OoCs (as one of the most promising microfluidic platforms) and those without embedding hydrogels. [315][316][317][318] The difference between these devices and other traditional cell platforms is that they can be used for biochemical, mechanical, and electrical stimulations. [319,320] Besides, OoCs can substitute animal models and markedly reduce experiments' time and cost.…”

Section: Development Of Cartilage-related Organ-on-chipsmentioning

confidence: 99%

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

et al. 2023

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Cartilage degeneration is among the fundamental reasons behind disability and pain across the globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none have shown acceptable outcomes in the long run. In this regard, the convergence of tissue engineering and microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives to current treatments and traditional constructs used in tissue engineering applications. Herein, the current developments involving microfluidic hydrogel‐based scaffolds, promising structures for cartilage regeneration, ranging from hydrogels with microfluidic channels to hydrogels prepared by the microfluidic devices, that enable therapeutic delivery of cells, drugs, and growth factors, as well as cartilage‐related organ‐on‐chips are reviewed. Thereafter, cartilage anatomy and types of damages, and present treatment options are briefly overviewed. Various hydrogels are introduced, and the advantages of microfluidic hydrogel‐based scaffolds over traditional hydrogels are thoroughly discussed. Furthermore, available technologies for fabricating microfluidic hydrogel‐based scaffolds and microfluidic chips are presented. The preclinical and clinical applications of microfluidic hydrogel‐based scaffolds in cartilage regeneration and the development of cartilage‐related microfluidic chips over time are further explained. The current developments, recent key challenges, and attractive prospects that should be considered so as to develop microfluidic systems in cartilage repair are highlighted.

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Section: Development Of Cartilage-related Organ-on-chipsmentioning

confidence: 99%

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

et al. 2023

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“…Therefore, the utmost need is to have a pathogenetic mechanism and diagnostic and therapeutic tools to overcome various cardiotoxicity and CVDs, such as coronary artery disease, cardiac ischemia, myocardial infarction (MI), cardiomyopathy, rheumatic heart disease, heart valve disease, stroke, arrhythmias, congenital heart defects, and other vascular diseases. , A tremendous number of efforts have been made by various scientists on animal models and drug discovery models to provide a substantial solution for CVDs. Unfortunately, there is a translational gap when it comes to an actual physiological condition of a human heart and clinical trials along with lengthy and expensive procedures . Systematically, we can categorize the research of CVDs based on three different aspects: pathogenesis investigation of the disease, precise diagnostic methods, and effective therapeutics .…”

Section: Single Organ-on-a-chipmentioning

confidence: 99%

“…Unfortunately, there is a translational gap when it comes to an actual physiological condition of a human heart and clinical trials along with lengthy and expensive procedures. 50 Systematically, we can categorize the research of CVDs based on three different aspects: pathogenesis investigation of the disease, precise diagnostic methods, and effective therapeutics. 51 Microfluidic devices provided without cells (cardiac biomarkers), with cells, tissue, or organ, lead the research of CVDs by delivering a multipurpose modeling platform from pathogenesis to diagnostics and therapeutics.…”

Section: ■ Single Organ-on-a-chipmentioning

confidence: 99%

Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics

et al. 2023

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“…The ability of the organ-on-a-chip to simulate diseases and drug metabolism has spurred enormous interest in commercializing these devices for clinical and industrial applications. 44 Currently, the drive to reduce reliance on animal models is strong in biomedical, food, cosmetics, and other related industries, 39,130,131 which has prompted regulatory bodies such as the US Food and Drug Association and the European Medicines Agency to seriously evaluate the technology 28,132 (for a list of organ-chip manufacturing companies, refer to Singh et al 130 ). In the biomedical industry, in particular, the demand for a robust in vitro platform has been growing considering the present lengthy, complicated, and time-consuming drug discovery process.…”

Section: Applications Of Gut-on-a-chip Devicesmentioning

confidence: 99%

Gut-on-a-chip models for dissecting the gut microbiology and physiology

2023

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Microfluidic technologies have been extensively investigated in recent years for developing organ-on-a-chip-devices as robust in vitro models aiming to recapitulate organ 3D topography and its physicochemical cues. Among these attempts, an important research front has focused on simulating the physiology of the gut, an organ with a distinct cellular composition featuring a plethora of microbial and human cells that mutually mediate critical body functions. This research has led to innovative approaches to model fluid flow, mechanical forces, and oxygen gradients, which are all important developmental cues of the gut physiological system. A myriad of studies has demonstrated that gut-on-a-chip models reinforce a prolonged coculture of microbiota and human cells with genotypic and phenotypic responses that closely mimic the in vivo data. Accordingly, the excellent organ mimicry offered by gut-on-a-chips has fueled numerous investigations on the clinical and industrial applications of these devices in recent years. In this review, we outline various gut-on-a-chip designs, particularly focusing on different configurations used to coculture the microbiome and various human intestinal cells. We then elaborate on different approaches that have been adopted to model key physiochemical stimuli and explore how these models have been beneficial to understanding gut pathophysiology and testing therapeutic interventions.

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Journey of organ on a chip technology and its role in future healthcare scenario

Cited by 39 publications

References 100 publications

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics

Gut-on-a-chip models for dissecting the gut microbiology and physiology

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