Joint status and related risk factors in patients with severe hemophilia A: a single-center cross-sectional study

Zhao, Liang; Yang, Hongbin; Li, Yaochun; Wang, Zhongqing; Zhou, Li; Zhao, Xielan; Peng, Jie

doi:10.1080/16078454.2021.2019892

Cited by 6 publications

(10 citation statements)

References 30 publications

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“…However, 14.3% of joints we observed were normal on the ultrasound examination but scored on the HJHS, consistent with previous findings 15,16 . These findings on HJHS may be due to small changes unrelated to hemophilia.…”

Section: Discussionsupporting

confidence: 92%

“…The HEAD-US-C score can be used as an objective assessment indicator for hemophilic arthropathy. [12][13][14][15] However, 14.3% of joints we observed were normal on the ultrasound examination but scored on the HJHS, consistent with previous findings. 15,16 These findings on HJHS may be due to small changes unrelated to hemophilia.…”

Section: Discussionsupporting

confidence: 91%

“…[12][13][14][15] However, 14.3% of joints we observed were normal on the ultrasound examination but scored on the HJHS, consistent with previous findings. 15,16 These findings on HJHS may be due to small changes unrelated to hemophilia. A study of healthy adults revealed that 40% of healthy young adults scored up to 3 on the HJHS, but all were normal on MRI and concluded that scores up to 3 points should be considered as normal in young adults.…”

Section: Discussionsupporting

confidence: 91%

“…The more severe the joint lesion detected by ultrasound, the more severe the functional and physical changes of the joint exhibited on physical examination. The HEAD‐US‐C score can be used as an objective assessment indicator for hemophilic arthropathy 12–15 …”

Section: Discussionmentioning

confidence: 99%

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The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee

Fang

Guo

Qin

et al. 2022

J of Ultrasound Medicine

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Objectives-We aimed to discuss the correlation between the Hemophilia Early Detection Ultrasound in China (HEAD-US-C) score and the Hemophilia Joint Health Score version 2.1 (HJHS 2.1) of the knee joint in patients with hemophilia.Methods-We included 70 male patients with hemophilia admitted to The Second Hospital of Shanxi Medical University; the patients' bilateral knee joints were evaluated using the HEAD-US-C score and HJHS. We analyzed factors influencing hemophilia arthropathy of the knee and examined the correlation between the HEAD-US-C score and HJHS.Results-The joint injury severity was positively correlated with age and the number of bleeds (P < .001). Further, the HEAD-US-C score and HJHS differed according to the severity (both P < .001), but not type (P = .163 and P = .283, respectively), of hemophilia. There was a significant correlation between the HEAD-US-C score and HJHS (P < .001).Conclusions-Overall, all joint lesions observed on ultrasound corresponded to clinical joint functional abnormalities. Therefore, the HEAD-US-C is important for hemophilic arthropathy evaluation and is useful in explaining abnormal joint function.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee

Fang

Guo

Qin

et al. 2022

J of Ultrasound Medicine

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“…1 Hemophilic arthropathy is the most common complication of severe hemophilia. 2 The most common clinical manifestation of hemophilia is spontaneous or traumatic bleeding. Overall, 90% of all bleeding episodes occur in the musculoskeletal system, with joints accounting for 80% of all hemorrhage locations.…”

mentioning

confidence: 99%

Hemophilia Joint Health Score, Functional Independence Score in Hemophilia, and Pettersson Score in Pediatric Patients With Severe Hemophilia A

Mabrouk

Abbas

Ezzat

et al. 2023

Journal of Pediatric Hematology/Oncology

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Hemophilia is an X-linked recessive disorder. Children with hemophilia go through spontaneous and trauma-provoked bleeding. Recurring joint bleeds lead to ongoing incapacity. Achieving healthy joints is the primary target of hemophilia management. The current study objective was to assess hemophilic joints in individuals with hemophilic arthropathy clinically, radiographically, and functionally. This cross-sectional study included 50 children with severe hemophilia A who were selected from the pediatric hematology clinic. All children were assessed for Hemophilia Joint Health Score (HJHS). Joint assessed functionally by Functional Independence Score in Hemophilia (FISH) and radiologically by plain radiograph and scored by the Pettersson scoring system. Data were analyzed using Statistical Package for Social Sciences. The mean age of the studied cases of hemophilia was 8.5±3.1 years. The mean FISH score among the studied patients was 26.8±4.2, the mean HJHS was 16.8±12.8, and the Pettersson score was 4.9±2.7. The number of affected joints showed a significant negative correlation to the FISH score and a significant positive correlation to HJHS. The frequency of hemarthrosis/month showed a significant positive correlation to HJHS. The number of affected joints showed a significant negative correlation to the FISH score and a significant positive correlation to HJHS. Frequency of hemarthrosis/month showed a significant positive correlation to HJHS.

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Diagnostic Value of the HEAD‐US‐C Scale for the Knees of Severe Hemophilia A Patients

Fang,

Sun,

Chang

et al. 2023

J of Ultrasound Medicine

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ObjectivesThis study aimed to assess the reliability of the Hemophilia Early Arthropathy Detection with Ultrasound in China (HEAD‐US‐C) scale for the knees of severe hemophilia A (SHA) patients and to determine its diagnostic accuracy for assessments of knee‐joint lesions in comparison with magnetic resonance imaging (MRI).MethodsWe collected data from 32 knee joints of 21 patients diagnosed with SHA. The knees were evaluated based on the HEAD‐US‐C scale and the results were compared with the International Prevention Study Group (IPSG) scale. The HEAD‐US‐C scale was applied independently by two trained ultrasonographers blinded to the MRI results. The IPSG scale was applied independently by two radiologists blinded to the clinical data and ultrasound (US) results.ResultsThe IPSG and HEAD‐US‐C scales exhibited good to excellent inter‐rater reliability. Additionally, there was good to excellent agreement between the US and MRI results for the detection of knee lesions in SHA patients. The sensitivities of US for joint effusion, synovial hyperplasia, cartilage loss, and bone‐surface irregularities in the knees of patients were 92.59, 100, 95.45, and 87.50%, respectively. The HEAD‐US‐C scale was positively correlated with the IPSG scale.ConclusionsUS is important for evaluating knee lesions in patients with SHA and may potentially replace MRI.

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Joint status and related risk factors in patients with severe hemophilia A: a single-center cross-sectional study

Cited by 6 publications

References 30 publications

The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee

The Correlation Between the HEAD‐US‐C Score and HJHS in Hemophilic Arthropathy of the Knee

Hemophilia Joint Health Score, Functional Independence Score in Hemophilia, and Pettersson Score in Pediatric Patients With Severe Hemophilia A

Diagnostic Value of the HEAD‐US‐C Scale for the Knees of Severe Hemophilia A Patients

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