In order to study the deformation evolution law of fault activation caused by deep mining in Shizishan Copper Mine, China, a monitoring system for fault activation slip is designed and implemented on the basis of the field investigation of footwall fault activation of the main orebody in the mining area. The displacement and stress of the fault are monitored by the multipoint displacement meter, bolt stress meter, and borehole stress meter. According to the measured results, the activation deformation laws of fault F2, fault F3, and fault F4 during deep continuous mining are analyzed in detail. The results show that, when the influence range of underground mining spreads to the fault, the increase in the additional tensile stress on the fault plane will reduce the shear strength of the fault and increase the slip of the fault. When the shear stress exceeds the shear strength of the fault plane, the shear failure of the fault plane occurs, the rock mass on both sides of the fault loses stability, and the fault becomes active; when the orebody in the deep sublevel 14 and sublevel 15 were continuously stoped, the development of the mining influence area to fault F2 leads to fault F2’s activation. When stoping the orebody in sublevel 16, fault F3 also activates. With the continuous downward mining of the deep part, the slip amount increases continuously. The fault activation sequence is from fault F2 to fault F3, and then to fault F4.