Joint lavage followed by viscosupplementation and triamcinolone in patients with severe haemophilic arthropathy: objective functional results

Rezende, Márcia Uchôa de; Andrusaitis, Félix Ricardo; Silva, R. T.; Okazaki, Erica; Carneiro, Jorge David Aivazoglou; Campos, Gustavo Constantino de; Pailo, A.F.; Frucchi, Renato; Pasqualin, Thiago; Villaça, Paula Ribeiro

doi:10.1111/hae.13115

Cited by 13 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For active patients, or with more advanced OA stages, the control they provide over signs and symptoms may be insufficient (30,31,37). Since OA is symptomatic only in the affected joint, while lacking obvious extra-articular manifestations, it is well-suited to have a local therapy administered by intra-articular injection, reducing the total amount required to produce an effect, compared with a systemic administration (38)(39)(40). Still, this approach presents some disadvantages, as the need of a precise diagnosis, the learning curve inherent to the execution of the procedure (particularly when considering hips), better conducted with the assistance of fluoroscopy or ultrasound, and the need of placing the patient under sedation or general anesthesia.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs

Alves

Santos²,

Jorge³

et al. 2020

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs

Alves

Santos²,

Jorge³

et al. 2020

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Lastly, Rezende et al . demonstrated that joint lavage followed by injections of triamcinolone and Hylan G-F 20 (viscosupplement) improved balance, function, and bleeding events in patients with severe HA 73 , and Li et al . suggest that a single intra-articular platelet-rich plasma injection results in better improvement in pain relief, joint function, and reduced synovial hyperemia when compared with five weekly intra-articular injections of hyaluronic acid in patients with HA of the knee 74 .…”

Section: A New Wave In the Evaluation Of Hemophilic Arthropathymentioning

confidence: 99%

Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia

Bakeer

Shapiro

2019

F1000Res

View full text Add to dashboard Cite

Bleeding with resultant hemophilic arthropathy constitutes the largest cause of morbidity in patients with hemophilia. It results from repeated bleeding episodes in the joint and is characterized by synovial hypertrophy and cartilage and bony destruction. Hemophilic arthropathy assessment is a continually evolving process and is particularly challenging in children and young adults in whom joint disease may be missed or underestimated as obtaining serial “baseline” magnetic resonance imaging scans of multiple clinically asymptomatic or nearly asymptomatic joints may be unjustifiable and cost-ineffective. Musculoskeletal ultrasound—particularly, point-of-care musculoskeletal ultrasound—has emerged as a promising imaging modality for the early detection and management of hemophilic arthropathy, and for the evaluation of hemarthrosis and painful musculoskeletal episodes in patients with hemophilia. This review summarizes currently available data on the emerging role of this new imaging modality, its limitations, and gaps in knowledge. The review also raises unanswered questions, highlights the need for consolidated research efforts, and delineates future directions expected to advance this technology and optimize its use in this patient population.

show abstract

“…1 Haemophilic arthropathy (HA) is a form of joint degeneration that clinically leads to disability, articular deformity, chronic pain and impaired quality of life. 3 The pathophysiology of haemophilic arthropathy is somewhat clinically and biologically similar with rheumatoid arthritis (RA) and osteoarthritis (OA). 3 The pathophysiology of haemophilic arthropathy is somewhat clinically and biologically similar with rheumatoid arthritis (RA) and osteoarthritis (OA).…”

Section: Introductionmentioning

confidence: 99%

“…The inflammatory components represented by synovitis and bone resorption are similar to RA, while the joint cartilage degeneration is similar to OA. [3][4][5][6][7] The aims of this study were (a) to evaluate the efficacy of HAc, CO, PRP and MSC in patients with haemophilic arthropathy, (b) to compare the efficacy of these 4 drugs and (c) to establish the scientific validity of the use of these drugs and determine their safety. 4 Intra-articular injections of hyaluronic acid and corticosteroids are commonly used, alone or in combination, in patients with painful knee osteoarthritis and provide pain relief for weeks (corticosteroids) or months (hyaluronic acid).…”

Section: Introductionmentioning

confidence: 99%

Haemophilic arthropathy: A narrative review on the use of intra‐articular drugs for arthritis

et al. 2019

View full text Add to dashboard Cite

Introduction: Intra-articular injections of various drugs are commonly used in patients with degenerative osteoarthritis and also in haemophilic patients. Haemophilic arthropathy is a particular type of secondary osteoarthritis (OA), but the degeneration of strong synovial, cartilaginous and subchondral constituents is provoked by the direct action of iron and blood in the joint.Aim of the study: The aim of this study is to review the literature regarding the use of various intra-articular drugs in joints affected by haemophilic arthropathy. Methods: We reviewed the data from the literature; the search was performed on three medical electronic databases (PubMed, Cochrane Library and Scopus Web of Science) by three authors (B. E., A. M. and V. N.) from 3 December 2018 till 15 December 2018. The search string was as follows: (hyaluronic acid OR viscosupplementation OR platelet-rich plasma OR corticosteroid OR mesenchymal stem cells) AND (haemophilia OR haemophilic arthropathy OR haemophilic arthritis).Results: Once the research was performed, a total of 300 articles were identified. 47 selected articles were analysed by the reviewers, and the eligibility of the study inclusion was assessed independently. Twelve papers were included based on clear fulfilment of the inclusion criteria. Thirty-five articles were excluded for the following reasons: no full text or accessible data for 14 of them, 15 involved surgery or rehabilitation therapy as the primary topic and 6 were systematic reviews (the main topics were beyond the haemophilic arthropathy). Conclusion:Although the degree of scientific evidence of the publications on intraarticular injections of various drugs (hyaluronic acid, corticosteriods, PRP and MSCs) in haemophilia is very low, it seems that intra-articular injections of hyaluronic acid can relieve joint pain for months and can be repeated every 6-12 months, which is why they can be recommended. Corticosteroid injections seem to relieve joint pain for a few weeks, but their routine use is not recommended in haemophilia. The efficacy of PRP and MSCs in haemophilic arthropathy is pending confirmation, which is why they are not currently recommended. K E Y W O R D Sarthritis, arthropathy, drugs, haemophilia

show abstract

Joint lavage followed by viscosupplementation and triamcinolone in patients with severe haemophilic arthropathy: objective functional results

Abstract: Joint lavage followed by injections of triamcinolone and Hylan G-F20 improved balance, function and bleeding events in severe haemophilic arthropathy patients.

Cited by 13 publications

References 33 publications

A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs

A Pilot Study on the Efficacy of a Single Intra-Articular Administration of Triamcinolone Acetonide, Hyaluronan, and a Combination of Both for Clinical Management of Osteoarthritis in Police Working Dogs

Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia

Haemophilic arthropathy: A narrative review on the use of intra‐articular drugs for arthritis

Contact Info

Product

Resources

About