Joint Instability and Osteoarthritis

Blalock, Darryl; Miller, A.; Tilley, Michael; Wang, Jinxi

doi:10.4137/cmamd.s22147

Cited by 115 publications

(108 citation statements)

References 65 publications

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“…The major components of articular cartilage are water, extracellular matrix (ECM), and chondrocytes. 18 Several researchers [28][29][30][31] have hypothesized that abnormal loading secondary to joint instability could disrupt the ECM. This disruption in the ECM may lead to the release of glycosylated aminoglycans and collagen molecules.…”

Section: Discussionmentioning

confidence: 99%

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Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space

Hubbard-Turner

Wikstrom

Guderian

et al. 2017

Journal of Athletic Training

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Context: Ankle sprains remain the most common orthopaedic injury. Conducting long-term studies in humans is difficult and costly, so the long-term consequences of an ankle sprain are not entirely known. Objective: To measure knee-joint space after a single surgically induced ankle sprain in mice. Design: Randomized controlled trial. Setting: University research laboratory. Patients or Other Participants: Thirty male mice (CBA/2J) were randomly placed into 1 of 3 surgical groups: the transected calcaneofibular ligament (CFL) group, the transected anterior talofibular ligament/CFL group, or a sham treatment group. The right ankle was operated on in all mice. Main Outcome Measure(s): Three days after surgery, all of the mice were individually housed in cages containing a solid-surface running wheel, and daily running-wheel measurements were recorded. Before surgery and every 6 weeks after surgery, a diagnostic ultrasound was used to measure medial and lateral knee-joint space in both hind limbs. Results: Right medial (P = .003), right lateral (P = .002), left medial (P = .03), and left lateral (P = .002) knee-joint spaces decreased across the life span. The mice in the anterior talofibular ligament/CFL group had decreased right medial (P = .004) joint space compared with the sham and CFL groups starting at 24 weeks of age and continuing throughout the life span. No differences occurred in contralateral knee-joint degeneration among any of the groups. Conclusions: Based on current data, mice that sustained a surgically induced severe ankle sprain developed greater joint degeneration in the ipsilateral knee. Knee degeneration could result from accommodation to the laxity of the ankle or biomechanical alterations secondary to ankle instability. A single surgically induced ankle sprain could significantly affect knee-joint function.

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Section: Discussionmentioning

confidence: 99%

“…[16][17][18] Altered joint loading at the knee has been suggested to contribute to knee OA. Biomechanical changes such as those described earlier may modify the regions where tibiofemoral joint contact occurs.…”

mentioning

confidence: 99%

Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space

Hubbard-Turner

Wikstrom

Guderian

et al. 2017

Journal of Athletic Training

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“…Magnification:×100. Control: saline; P3w: papain injection for three weeks; P6w: papain injection for six weeks; P+ACLT: papain injection for six weeks + ACLT for three weeks after the last injection Normally, ligaments are pivotal for the stability of the joint because they offer mechanical reinforcement and throughout control the range of motion [1]. In patients with a total knee replacement (TKA), retaining PCL can assist in maintaining the natural knee movements and increasing the 'normal' feeling [30].…”

Section: Discussionmentioning

confidence: 99%

“…When the stability of the knee joint is broken, the unstable joint will lose the self-stabilization function and therefore be at a high risk of abrupt repositioning events which are associated with altered joint movement patterns and contact mechanics [3]. Therefore, the instability-associated changes of the joint may result in abnormal mechanical loading on the articular surface and subsequent lesions of the articular cartilage [1]. If the articular cartilage damage is not successfully and timely repaired, the affected joint will progress to osteoarthritis (OA).…”

Section: Introductionmentioning

confidence: 99%

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Section of the anterior cruciate ligament in the rabbit as animal model for osteoarthritis progression

Yin

et al. 2015

International Orthopaedics (SICOT)

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Morphological Study: Ultrastructural Aspects of Articular Cartilage and Subchondral Bone in Patients Affected by Post‐Traumatic Shoulder Instability

Baudi

Catani

Rebuzzi

et al. 2017

The Anatomical Record

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Post-traumatic shoulder instability is a frequent condition in active population, representing one of most disabling pathologies, due to altered balance involving joints. No data are so far available on early ultrastructural osteo-chondral damages, associated with the onset of invalidating pathologies, like osteoarthritis-OA. Biopsies of glenoid articular cartilage and sub-chondral bone were taken from 10 adult patients underwent arthroscopic stabilization. Observations were performed under Transmission Electron Microscopy-TEM in tangential, arcuate and radial layers of the articular cartilage and in the sub-chondral bone. In tangential and arcuate layers chondrocytes display normal and very well preserved ultrastructure, probably due to the synovial liquid supply; otherwise, throughout the radial layer (un-calcified and calcified) chondrocytes show various degrees of degeneration; occasionally, in the radial layer evidences of apoptosis/autophagy were also observed. Concerning sub-chondral bone, osteocytes next to the calcified cartilage also show signs of degeneration, while osteocytes farther from the osteo-chondral border display normal ultrastructure, probably due to the bone vascular supply. The ultrastructural features of the osteo-chondral complex are not age-dependent. This study represents the first complete ultrastructural investigation of the articular osteo-chondral complex in shoulder instability, evaluating the state of preservation/viability of both chondrocytes and osteocytes throughout the successive layers of articular cartilage and sub-chondral bone. Preliminary observations here collected represent the morphological basis for further deepening of pathogenesis related to shoulder instability, enhancing the relationship between cell shape and microenvironment; in particular, they could be useful in understanding if the early surgical treatment in shoulder instability could avoid the onset of OA. Anat Rec, 300:1208-1218, 2017. © 2016 Wiley Periodicals, Inc.

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Joint Instability and Osteoarthritis

Cited by 115 publications

References 65 publications

Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space

Acute Ankle Sprain in a Mouse Model: Changes in Knee-Joint Space

Section of the anterior cruciate ligament in the rabbit as animal model for osteoarthritis progression

Morphological Study: Ultrastructural Aspects of Articular Cartilage and Subchondral Bone in Patients Affected by Post‐Traumatic Shoulder Instability

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