Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease

Jia, Chongqi; Liu, Tongtao; Liu, Zhaolan; Li, Min; Hu, Mao-hong

doi:10.1016/j.thromres.2006.12.023

Cited by 23 publications

(14 citation statements)

References 25 publications

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“…Similar combined models have already been studied for various diseases (Lindpaintner et al 1995;Jia et al 2007). Therefore, in order to estimate the risk (OR) for a member of the studied European population to develop oral cancer, according to Table 5 variables, the following formula may be used:…”

Section: Discussionmentioning

confidence: 93%

Gene expression polymorphisms of interleukins-1β, -4, -6, -8, -10, and tumor necrosis factors-α, -β: regression analysis of their effect upon oral squamous cell carcinoma

Vairaktaris

Yapijakis

Serefoglou

et al. 2008

J Cancer Res Clin Oncol

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Section: Discussionmentioning

confidence: 93%

Gene expression polymorphisms of interleukins-1β, -4, -6, -8, -10, and tumor necrosis factors-α, -β: regression analysis of their effect upon oral squamous cell carcinoma

Vairaktaris

Yapijakis

Serefoglou

et al. 2008

J Cancer Res Clin Oncol

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“…These studies were then filtered to ensure conformity with the inclusion criteria. Six studies [15,16,17,18,19,20] were discarded for insufficient and equivocal data (although we tried unsuccessfully to obtain further information from the authors), 2 [12,21] were excluded because the controls were CAD patients, and 1 study [22] was excluded because its data were included in another study [1]. Finally, 30 references met our criteria, of which 23 (3 Asian and 20 non-Asian) studied the missense G894T variant, 19 (4 Asian and 15 non-Asian) studied the 27-bp tandem repeats 4b/a, and 14 (1 Asian and 13 non-Asian) studied the T-786C variant (table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The eNOS gene is polymorphic. The clinically most relevant eNOS variants are the missense G894T variant in exon 7, T-786C in the 5′-flanking region and 27-bp tandem repeats in intron 4 (4b/a) [12]. …”

Section: Introductionmentioning

confidence: 99%

The Endothelial Nitric Oxide Synthase Gene Is Associated with Coronary Artery Disease: A Meta-Analysis

Jun-yan

et al. 2010

Cardiology

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Introduction: Previous case-control studies have suggested that the endothelial nitric oxide synthase (eNOS) gene polymorphisms (G894T, 4b/a, T-786C) are associated with coronary artery disease (CAD). However, other studies do not confirm these relationships. The objective was to assess these relationships using meta-analysis. Methods: Databases, including Pubmed and Embase, were searched to access the relevant genetic association studies up to July 2009. Results: The meta-analysis included 56 studies, consisting of 23 studies for G894T, 19 for 4b/a and 14 for T-786C. For the allelic analysis of the G894T variant, all studies showed a positively significant association (OR = 0.83, p = 0.004). For the genotypic analysis, the combined studies of the T allele showed significance (OR = 1.57, p = 0.003). For the allelic analysis of the T-786C variant, all studies showed an obviously significant association (OR = 0.79, p = 0.0007), reflected in both non-Asian and Asian studies. For the genotype analysis, combined studies of the C allele showed significance (OR = 0.72, p = 0.0001). Moreover, non-Asian studies showed significant results. For the analysis of the 4b/a variant, none of the studies showed significant results. No publication bias was found in the meta-analysis. Conclusion: The synthesis of available evidence supports the fact that eNOS G894T andT-786C are associated with CAD.

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“…C oronary artery disease (CAD), resulting from atherosclerosis, is the leading cause of mortality in most developed countries ( Jia et al, 2007). In most cases CAD has a multifactorial genetic origin, although in some cases it develops as a consequence of disorders resulting from singlegene inheritance (Nordlie et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

Alp

Menevşe

Tulmaç³

et al. 2009

DNA and Cell Biology

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Polymorphic variants of genes encoding proteins involved in vascular remodeling may genetically diverge among different populations and play a role in the susceptibility to the coronary artery disease (CAD). MMP-9-1562 C/T (rs3918242), eNOS T-786C (rs2070744), and Glu298Asp (rs1799983) are among the most studied of these polymorphisms. The aim of this study was to determine the relationship between CAD and these polymorphisms in the Turkish population. The analysis included 146 CAD+ and 122 CAD- individuals. Genomic DNA was isolated from whole blood and genotyping was performed by the PCR-RFLP method. No significant associations were found between -1562 C/T (p = 0.557), Glu298Asp (p = 0.432), and -786 T/C (p = 0.055) polymorphisms and CAD. The distribution of each haplotype also did not differ between CAD+ and the CAD- samples (p > 0.05). The present investigation is the first to study an association between -1562 C/T polymorphism and CAD in the Turkish population. In conclusion, no appreciable differences between CAD+ and CAD- samples were found in terms of polymorphisms mentioned above.

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Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease

Cited by 23 publications

References 25 publications

Gene expression polymorphisms of interleukins-1β, -4, -6, -8, -10, and tumor necrosis factors-α, -β: regression analysis of their effect upon oral squamous cell carcinoma

Gene expression polymorphisms of interleukins-1β, -4, -6, -8, -10, and tumor necrosis factors-α, -β: regression analysis of their effect upon oral squamous cell carcinoma

The Endothelial Nitric Oxide Synthase Gene Is Associated with Coronary Artery Disease: A Meta-Analysis

Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

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