Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism

Gran, Olga Vikhammer; Smith, Erin N.; Brækkan, Sigrid Kufaas; Jensvoll, Hilde; Solomon, Terry; Hindberg, Kristian; Wilsgaard, Tom; Rosendaal, Frits R.; Frazer, Kelly A.; Hansen, John‐Bjarne

doi:10.3324/haematol.2016.147405

Cited by 32 publications

(35 citation statements)

References 58 publications

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“…BLOM et al (2005) found that cancer patients who were carriers of FV Leiden had 2.4-fold increased risk for VTE compared to patients with cancer and without mutation, while that risk increase 12-fold when compared to subjects without cancer or mutation. The similar results were obtained in the Tromso Study, where GRAN et al (2016) found that active cancer is associated with nearly 9-fold increased risk for thrombosis, suggesting a synergistic effect of FV Leiden and cancer. FALVELLA et al (2016) also reported increased frequency of FV Leiden in patients with metastatic colorectal cancer.…”

Section: Discussionsupporting

confidence: 84%

Inherited thrombophilic risk factors in Serbian breast cancer patients

Pruner

Tomic

et al. 2019

Genetika

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Breast cancer is the leading cause of cancer-related death among women. An increased burden of thrombotic events among breast cancer patients, leading to higher mortality and morbidity rates, is well established. There are a number of genetic risk factors associated with thrombosis, but their contribution to thrombotic tendencies in patients with cancer is not completely elucidated. We aimed to investigate possible role of FV Leiden, FII G20210A, MTHFR C677T and PAI-1 4G/5G gene variants in etiopathology of breast cancer and accompanying thrombosis in cohort of Serbian patients. Our study included 316 subject divided in three groups: breast cancer patients with (97) or without (99) accompanying thrombosis and healthy control group (120). According to our results, the prevalence for all four prothrombotic gene variants were similar in cancer patients with and without thrombosis and no statistically significant difference was observed between these groups. We detected lower frequency of MTHFR 677TT genotype in breast cancer patients when compared to control group (P=0.014; OR=0.145 (95%CI 0.031-0.679)), 464

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Section: Discussionsupporting

confidence: 84%

Inherited thrombophilic risk factors in Serbian breast cancer patients

Pruner

Tomic

et al. 2019

Genetika

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“…As the risk of cancer-associated VTE is high even 6 months before cancer diagnosis, and the peak incidence is from 0 to 6 months 1 , 31 post-diagnosis, it is recommended that the TiC-Onco score be calculated at the moment cancer is suspected. 32 , 33 …”

Section: Discussionmentioning

confidence: 99%

Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer

Martín

Ortega²,

Font

et al. 2018

Br J Cancer

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BackgroundVenous thromboembolism (VTE) is a leading cause of death among patients with cancer. Outpatients with cancer should be periodically assessed for VTE risk, for which the Khorana score is commonly recommended. However, it has been questioned whether this tool is sufficiently accurate at identifying patients who should receive thromboprophylaxis. The present work proposes a new index, TiC-Onco risk score to be calculated at the time of diagnosis of cancer, that examines patients’ clinical and genetic risk factors for thrombosis.MethodsWe included 391 outpatients with a recent diagnosis of cancer and candidates for systemic outpatient chemotherapy. All were treated according to standard guidelines. The study population was monitored for 6 months, and VTEs were recorded. The Khorana and the TiC-Onco scores were calculated for each patient and their VTE predictive accuracy VTEs was compared.ResultsWe recorded 71 VTEs. The TiC-Onco risk score was significantly better at predicting VTE than the Khorana score (AUC 0.73 vs. 0.58, sensitivity 49 vs. 22%, specificity 81 vs. 82%, PPV 37 vs. 22%, and NPV 88 vs. 82%).ConclusionsTiC-Onco risk score performed significantly better than Khorana score at identifying cancer patients at high risk of VTE who would benefit from personalised thromboprophylaxis.

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“…The incidence of DVT is expected to be increased by certain acquired or genetic risk factors. 19 The most commonly are: (a) Age. The DVT incidence increases with age, and it is very rare during childhood.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Clinical Profile, Predisposing Factors and Management of Deep Venous Thrombosis

Pal¹,

Amit²,

Virender³

et al. 2019

IJCMR

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Introduction: Deep venous thrombosis (DVT) of lower limbs is one of the most common cause for the majority of deaths caused by pulmonary embolism. Deep vein thrombosis is the formation of blood clots in the deep veins which commonly affects the leg veins such as the calf veins, femoral vein, or popliteal vein or veins of the pelvis. The aim of the study was to evaluate clinical profile of patients in form of age, sex, etiological factors of deep venous thrombosis in our institute. Also study risk the factors in patients of deep venous thrombosis. Material and Methods: Study was a prospective study which was conducted on 108 symptomatic patients of deep vein thrombosis which were proved by colour doppler ultrasonography. All patients who were more than 18 years of age and either sex were taken into study. Results: In our study 37.03% of the patients were males and 62,97% were females with majority belonging to 21-30 years of age group (33.82%). In this study the youngest patient was 20 years old female and the oldest patient was 96 years old female. Male: Female ratio was 1:1.7. The least common age group affected is extreme of age i.e. ≥ 20 years and > 60 years of age in both sexes. The most common limb affected is left lower limb 62 patients (57.40) and right limb involvement is seen in 39.81% of patients. Bilateral lower limb DVT is present in two patients and one patient was upper limb DVT. Predisposing factors associated with thrombosis in deep veins maximally seen in 46 patients in 42.59% due to unknown cause. Pregnancy and post-partum was the second most common predisposing factor associated with DVT which is seen in 33 patients in 30.55%. Thrombosis due to orthopaedic trauma is seen eight patients only. Chronic illness and malignancy was present in 19.44% of patients. Conclusion: It is very important for accurate diagnosis of DVT to prevent potentially fatal complications like pulmonary embolism (PE) and pulmonary hypertension. Also it is very important to avoid anticoagulants therapy with associated risk of bleeding in patients of misdiagnosed and negative colour doppler findings. Because clinical features are nonspecific; hence new strategies were evolved for diagnosing this condition.

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Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism

Cited by 32 publications

References 58 publications

Inherited thrombophilic risk factors in Serbian breast cancer patients

Inherited thrombophilic risk factors in Serbian breast cancer patients

Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer

A Prospective Study of Clinical Profile, Predisposing Factors and Management of Deep Venous Thrombosis

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