Joint Effects of Antibody to Heat Shock Protein 60, Hypertension, and Diabetes on Risk of Coronary Heart Disease in Chinese

Zhang, Xiaomin; He, Meian; Cheng, Long; Zhou, Li; Zeng, Hesong; Wang, Jing; Wang, Feng; Chen, Ying; Hu, Frank B.; Wu, Tangchun

doi:10.1373/clinchem.2007.101451

Cited by 16 publications

(21 citation statements)

References 36 publications

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“…7 Briefly, systolic blood pressure and fasting glucose in the CHD group were significantly higher than in the control subjects. Total cholesterol levels were significantly lower in CHD case subjects than in control subjects, and this was probably due to the higher incidence of cholesterol-lowering medication use.…”

Section: Characteristics Of Study Populationmentioning

confidence: 94%

“…The study design and subject demographics have been detailed previously. 7 Briefly, patients 40 to 79 years of age were recruited consecutively from 3 hospitals (Tongji Hospital, Union Hospital, and Wugang Hospital) in Wuhan (Hubei, China) between May 2004 and October 2006. The inclusion criteria for the case subjects were stenoses Ն50% in at least 1 major coronary artery by coronary angiography and/or a diagnosis of CHD based on the World Health Organization criteria.…”

Section: Study Populationmentioning

confidence: 99%

“…AntiHsp60 antibody levels were determined by enzyme immunoassay and levels expressed as arbitrary units per milliliter, as described previously. 7 …”

Section: Analysis Of Plasma Hsp60 and Anti-hsp60 Antibody Levelsmentioning

confidence: 99%

“…4,5 Work from our laboratory and others has shown that high levels of antibody to human Hsp60 (anti-Hsp60) in the circulation are associated with the presence and severity of coronary heart disease (CHD). 6,7 Pockley et al 8 have reported that Hsp60 levels are associated with early cardiovascular disease in individuals with borderline hypertension, and Xu et al 9 have reported that Hsp60 levels are significantly elevated in subjects with prevalent/incident carotid atherosclerosis in a populationbased study involving 826 subjects. Pockley and colleagues have also reported that Hsp60 levels in individuals with established hypertension are similar to those in normotensive control subjects 10 and that Hsp60 levels in patients with peripheral and renal vascular disease are similar to those in corresponding control subjects.…”

mentioning

confidence: 99%

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Elevated Heat Shock Protein 60 Levels Are Associated With Higher Risk of Coronary Heart Disease in Chinese

Zhang

Cheng

et al. 2008

Circulation

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Background-Although heat shock protein 60 (Hsp60) is implicated in the pathogenesis of atherosclerosis, its role in coronary heart disease (CHD) is uncertain. This study explored the influence of circulating Hsp60 on CHD in a large case-control study, as well as the impact of acute myocardial infarction on Hsp60 levels in a prospective study. Methods and Results-Plasma Hsp60 and anti-Hsp60 antibody levels were determined by immunoassay. In the case-control study (1003 patients with CHD, 1003 matched control subjects), Hsp60 levels were higher in patients with CHD and were related to CHD (OR comparing extreme quartilesϭ4.14, PϽ0.0001). This association remained after adjustment for traditional risk factors (P for trend Ͻ0.0001). Individuals having high levels of Hsp60 (greater than the median of 160.24 ng/mL) and anti-Hsp60 antibody (greater than the median of 38.42 U/mL) were at a greater risk of CHD than those with low levels (OR 2.30, PϽ0.0001). Stronger additive effects (OR 14.04, PϽ0.0001) were apparent at higher Hsp60 and anti-Hsp60 antibody levels (Ͼ1000 ng/mL and greater than the median of 38.42 U/mL, respectively). The simultaneous presence of high Hsp60 and anti-Hsp60 antibody levels, current smoking, hypertension, and diabetes were cumulatively associated with CHD. Individuals who had any 4 or more of these 5 factors had an OR of 38.61 for CHD (PϽ0.0001) compared with individuals who had none of these factors. For the prospective study, blood was drawn from 20 patients immediately after admission for acute myocardial infarction and 2, 3, and 7 days thereafter. Hsp60 levels were significantly higher on the day of and the day after arrival than 7 days after an acute myocardial infarction (Pϭ0.011 and Pϭ0.026, respectively). Conclusions-Elevated

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Section: Characteristics Of Study Populationmentioning

confidence: 94%

Section: Study Populationmentioning

confidence: 99%

“…AntiHsp60 antibody levels were determined by enzyme immunoassay and levels expressed as arbitrary units per milliliter, as described previously. 7 …”

Section: Analysis Of Plasma Hsp60 and Anti-hsp60 Antibody Levelsmentioning

confidence: 99%

mentioning

confidence: 99%

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Elevated Heat Shock Protein 60 Levels Are Associated With Higher Risk of Coronary Heart Disease in Chinese

Zhang

Cheng

et al. 2008

Circulation

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“…Many population-based studies showed a strong correlation between ATS and high levels of soluble, circulating HSP60 [62][63][64][65][66] as well as of anti-HSP60 antibodies [65][66][67][68][69]. Both chaperonin and anti-chaperonin antibodies have been shown to elicit production of pro-inflammatory cytokines [59,70,71].…”

Section: Hsp60 and Its Bacterial Counterpart Are Pro-atherogenic Molementioning

confidence: 99%

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Rizzo¹,

Macario²,

Macario³

et al. 2011

CPD

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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotective but a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examples of specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD.

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Heat Shock Proteins in Vascular Disease

Mehta

2009

Heat Shock Proteins and Whole Body Physiology

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Joint Effects of Antibody to Heat Shock Protein 60, Hypertension, and Diabetes on Risk of Coronary Heart Disease in Chinese

Cited by 16 publications

References 36 publications

Elevated Heat Shock Protein 60 Levels Are Associated With Higher Risk of Coronary Heart Disease in Chinese

Elevated Heat Shock Protein 60 Levels Are Associated With Higher Risk of Coronary Heart Disease in Chinese

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Heat Shock Proteins in Vascular Disease

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