Abstract:Background. Toxic compounds are detoxified by several xenobiotic metabolizing enzymes such as N-acetyltransferase 2 (NAT2). The role for NAT2 genetic polymorphisms in different malignancies risk has been the subject of numerous studies. In the current study we investigated the association of genetic NAT2 variants or their corresponding acetylator phenotypes with bladder cancer risk. The relationship between NAT2 genotype/phenotype and smoking status was also evaluated as potential risk factor of urinary bladde… Show more
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