Joint Contractures Resulting From Prolonged Immobilization: Etiology, Prevention, and Management

Born, Christopher T.; Gil, Joseph A.; Goodman, Avi D.

doi:10.5435/jaaos-d-15-00697

Cited by 30 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Common pathologies causing immobilization related contractures are Rheumatoid arthritis, prolonged bed-rest and bone fractures [4]. In humans, contractures can develop in both upper-and lower extremities.…”

Section: Introduction/discussionmentioning

confidence: 99%

Contracture Development in Whales

Pingel¹,

Harrison²

2020

OJMS

View full text Add to dashboard Cite

show abstract

Section: Introduction/discussionmentioning

confidence: 99%

Contracture Development in Whales

Pingel¹,

Harrison²

2020

OJMS

View full text Add to dashboard Cite

show abstract

“…There was no significant difference between both the pBudCE4.1-miR-140 group and the pBudCE4.1-IGF-1 group. -433 prolonged immobilization, joint contractures often occur after conventional therapy (Born et al, 2017). Therefore, identifying and enhancing factors contributing to bone regeneration may increase the healing speed of fractures, leading to reduced risk in the development of joint contractures.…”

Section: Cartilagementioning

confidence: 99%

Incorporating insulin growth Factor‐1 into regenerative and personalised medicine for musculoskeletal disorders: A systematic review

Gan

Choy

Foo

et al. 2021

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Musculoskeletal disorders are commonly associated with decreased physical activities, which affect the quality of life. While current interventions carry complications, including post-operative complications and drug side effects, regenerative and personalized medicine had been researched. Till date, regenerative medicine in treating musculoskeletal disorders had been studied in various aspects, including the use of growth factors such as insulin growth factor-1 (IGF-1) to enhance healing potential. IGF-1 is one of the common growth factors secreted during the early phase of healing responsible for cellular migration, proliferation, secretion, and differentiation leading to musculoskeletal regeneration. This systematic review summarized the role of IGF-1 in musculoskeletal regeneration at the cellular level.An extensive literature search was done in PubMed Central and PubMed from 2009 to present, 2020. The inclusion criteria include the original research related to IGF-1 in musculoskeletal regeneration done in vivo or in vitro. During the search, 208 journals were identified, whereby, 34 had met the inclusion criteria. Most studies reported that incorporating IGF-1 into regenerative medicine enhances the healing potential of bones and cartilages while only a few focused on ligaments, tendons and muscles. The contradicting results reported among some studies show that role of IGF-1 in musculoskeletal regeneration differs depending on the presence of other factors in the culture medium or environment and the cell receptors. Hence, future studies should characterize all the known factors which may be important to enhance the healing potential of IGF-1 on the musculoskeletal system. Also, more studies should be conducted on ligaments, tendons, and muscles of the musculoskeletal system.

show abstract

“…A limitation in the passive ROM of affected joints is termed a joint contracture, and this can be detrimental for joint performance. [1,2] The development of contractures can arise as a consequence of injury/disease (requiring extended periods of immobility), [2][3][4][5][6] or due to treatment (prolonged use of bracing). [7] The pathophysiology of joint contractures is progressive in nature, where increases in the duration of immobilization increases the severity of ROM loss.…”

Section: Introductionmentioning

confidence: 99%

Embryonic movement stimulates joint formation and development: Implications in arthrogryposis multiplex congenita

Zhou

2021

BioEssays

View full text Add to dashboard Cite

Arthrogryposis multiplex congenita (AMC) is a heterogeneous syndrome where multiple joints have reduced range of motion due to contracture formation prior to birth.A common cause of AMC is reduced embryonic movement in utero. This reduction in embryonic movement can perturb molecular mechanisms and signaling pathways involved in the formation of joints during development. The absence of mechanical stimuli can impair joint cavitation, resulting in joint fusion, and ultimately eliminate function. In turn, mechanical stimuli are critical for proper joint formation during development and for mitigating AMC. Studies in experimental animal models have provided a greater understanding on the molecular pathophysiology of congenital contracture formation as a consequence of embryonic immobilization. Elucidation of how the mechanical signaling environment is transduced to initiate a biological response will be necessary to gain a deeper understanding of how mechanical stimuli are intertwined in the molecular regulation of joint development.

show abstract

Joint Contractures Resulting From Prolonged Immobilization: Etiology, Prevention, and Management

Cited by 30 publications

References 38 publications

Contracture Development in Whales

Contracture Development in Whales

Incorporating insulin growth Factor‐1 into regenerative and personalised medicine for musculoskeletal disorders: A systematic review

Embryonic movement stimulates joint formation and development: Implications in arthrogryposis multiplex congenita

Contact Info

Product

Resources

About