Jobelyn® attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice

How to study anxiety and depression in rodent models of chronic pain?

“…Again difficulties to show anxiety‐like behaviours can generally be explained by the testing time point being too early (Kontinen et al, 1999; Pitzer et al, 2019) or too late (Pitzer et al, 2019). When done in inflammatory condition, anxiety‐like behaviour was observed in the LDB from 1 to 28 days after induction (Narita, Kaneko, et al, 2006; Narita, Kuzumaki, et al, 2006; do Nascimento & Leite‐Panissi, 2014; Omorogbe et al, 2018; Parent et al, 2012; Table 2).…”

“…For other neuropathic pain models, increased in immobility time was observed between 4 weeks and 2 months (Aguilar‐Avila et al, 2019; Ferreira‐Chamorro et al, 2018; Gai et al, 2014; Guida et al, 2015; Wu et al, 2014; Zhang et al, 2019; Table 1; Figures 5 and 6). For inflammatory pain models, depressive‐like behaviours have been highlighted by the TST 7–14 days after CFA injection (Kim et al, 2012; Maciel et al, 2013; Omorogbe et al, 2018) and at 41 weeks in an osteoarthritis model (Griffin et al, 2010). Finally, in a fibromyalgia model, an increase in immobility time was observed within three post‐induction days (Klein et al, 2014).…”

The West African&nbsp;<em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn&reg; and Its Diverse Therapeutic Potentials

“…58 Charles et al demonstrates that Jobelyn ® Supplement Lowered Neuronal Degeneration. 59 Omorogbe et al 52 also shows that Jobelyn attenuates inflammatory responses induced by CFA in mice via inhibition of oxidative stress and release of inflammatory cytokines. 60 CFA-induced nociception, sensorimotor deficits and depressivelike symptom suggests it might improve the quality of life of patients with arthritic conditions.…”

“…The Omega balance is critical as Omega-3 and Omega-6 compete for absorption into the cells, and an excess of dietary Omega-6 will result in too few of Omega-6 being incorporated into cell membranes, from where they exert their essential effects. 52 Earlier in the HIV epidemic the observation of increased oxidative stress and elevated cytokines led to a dietary intervention study on whether supplementation with Omega-3 fatty acids would decrease cytokines or markers of inflammation. Omega 3 showed beneficial effects on systemic inflammation mediated my multiple mechanisms including a decrease in the activation of NFkB by inflammatory stimuli.…”

Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl] 4-Chlorobenzoselenolate Attenuates Inflammatory Response, Nociception, and Affective Disorders Related to Rheumatoid Arthritis in Mice

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of synovial membrane and known to damage and destroy the cartilage and bone tissue that form the joints. − RA patients commonly report pain, which affects several joints simultaneously and causes stiffness, fatigue, reduced range of motion, and muscle weakness. In addition, roughly 0.5–1% of the adult population, worldwide, is affected by RA, and this number is 2–3 times higher in women than men …”