Growing competition and the increasing need for adaptability often require organizations to switch and convert themselves according to the demand of circumstances. In this process of reformation, employee performance gets affected by many aspects. Aiming at connecting two broad occupational concepts this article analyses and tests the effect of Job Design and Ergonomics on Employee Performance and the relatedness of Job Design and Ergonomics. The research was conducted in 32 organizations, having managers and supervisors at about 64 categories of designations handling teams of workers in the manufacturing units, of the automotive sector of India. This quantitative study, based on a sample collected through 5 points Likert scale questionnaires, was analysed using Confirmatory Factor Analysis (CFA), correlation, and multivariate regression analysis. The results manifested that CFA model and regression analysis described a significant impact of Job Design and Ergonomics on Employee Performance. The correlation outcomes revealed that Job Design and Ergonomics were well connected having p-value of .00, p < .005. The findings suggested, while focusing on improving the employee upshot, it becomes necessary for organizations to include Ergonomics in Job Design as a Design for Safety.