Job Characteristics and Blood Coagulation Factors in Korean Male Workers

Chang, Sei Jin; Koh, Sang Baek; Suk, Bong; Park, Jong Ku

doi:10.1097/00043764-200211000-00004

Cited by 20 publications

(11 citation statements)

References 26 publications

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“…10 Further, several studies support the use of the DC model in predicting cardiovascular disease risk. [2][3][4][25][26][27][28][29][30][31][32][33] …”

Section: Job Strainmentioning

confidence: 99%

Job Strain, Ethnicity, and Sympathetic Nervous System Activity

et al. 2004

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Abstract-Several studies have demonstrated that blacks have heightened pressor sensitivity in response to the ␣-agonist, phenylephrine. However, studies examining whether psychosocial factors contribute to this difference are scarce. We examined the effects of job strain on pressor sensitivity in 76 whites and 46 blacks who were enrolled in a study of stress, sleep, and blood pressure. Responses to phenylephrine were examined at an inpatient clinical research center. After a 3-minute baseline period, a 100-microgram phenylephrine bolus was administered to participants intravenously. To measure catecholamines, 24-hour urine samples were also collected from participants. There was a significant relationship between job strain and pressor sensitivity, such that individuals with low decisional control and high job demands experienced a greater increase in diastolic pressure after receiving phenylephrine. Low decisional control was also associated with decreased baroreflex sensitivity. There was an interaction between ethnicity and job control on blood pressure responses to phenylephrine and on 24-hour urinary norepinephrine levels. Blacks who perceived less control experienced a greater increase in diastolic pressure after receiving phenylephrine and had elevated norepinephrine levels. These findings suggest possible mechanisms by which job strain may be associated with cardiovascular disease.

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“…10 Further, several studies support the use of the DC model in predicting cardiovascular disease risk. [2][3][4][25][26][27][28][29][30][31][32][33] …”

Section: Job Strainmentioning

confidence: 99%

Job Strain, Ethnicity, and Sympathetic Nervous System Activity

et al. 2004

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“…2,4 FVIII levels in nonhemophilic populations are broadly variable, spanning a greater than 5-fold range. 5,6 Age, [7][8][9][10][11][12] sex, 7,9 oral contraception (OC), 10,13 smoking, 7,14,15 body-mass index (BMI), 7,12,16,17 diabetes mellitus (DM), 7,16 ABO blood type, [17][18][19][20][21][22] and plasma levels of total cholesterol (TC), 16,17 low-density lipoprotein (LDL), 16,17,23 triglyceride (TG), 16,17 VWF, [24][25][26][27][28][29] and FIX coagulant activity (FIX: C) 10,24,30 all have ample evidence supporting their role as correlates of FVIII:C. Family studies, which have yielded heritability estimates ranging between 40% and 57% and 20% and 61%, respectively, for the levels of FVIII:C 21,31 and FVIII antigen (FVIII: Ag), [32]…”

Section: Introductionmentioning

confidence: 99%

A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels

Viel

Machiah²,

Warren

et al. 2007

Blood

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Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to contribute to the broad population variability observed for this trait. Because less than 2.5% of the structural FVIII gene (F8) has been examined previously, we resequenced all known functional regions in 222 potentially distinct alleles from 137 unrelated nonhemophilic individuals representing 7 racial groups. Eighteen of the 47 variants identified, including 17 single-nucleotide polymorphisms (SNPs), were previously unknown. As the degree of linkage disequilibrium across F8 was weak overall, we used measuredgenotype association analysis to evaluate the influence of each polymorphism on the FVIII:C levels in 398 subjects from 21 pedigrees known as the Genetic Analysis of Idiopathic Thrombophilia project (GAIT). Our results suggested that 92714C>G, a nonsynonymous SNP encoding the B-domain substitution D1241E, was significantly associated with FVIII:C level. After accounting for important covariates, including age and ABO genotype, the association persisted with each C-allele additively increasing the FVIII:C level by 14.3 IU dL ؊1 (P ‫؍‬ .016). Nevertheless, because the alleles of 56010G>A, a SNP within the 3 splice junction of intron 7, are strongly associated with 92714C>G in GAIT, additional studies are required to determine whether D1241E is itself a functional variant. (Blood. 2007;109:3713-3724)

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“…Along with these changes, compensation claims for work-related cardiovascular diseases, musculoskeletal diseases and mental illness sharply increased (Korean Ministry of Labor 2005) and this has been attributed to job stress resulting from the unstable labour market. Several recent studies have reported that South Korean workers are exposed to severe job insecurity and are suVering from the health eVects of job stress (Chang et al 2002;Kang et al 2004Kang et al , 2005Eum et al 2006). The restructuring of the labour market has resulted in a growing wage diVerential, forced mobility and job insecurity, which would all contribute to the breakdown of social reciprocity.…”

Section: Introductionmentioning

confidence: 99%