Jnk1 and Downstream Signalling Hubs Regulate Anxiety-like Behaviours in a Zebrafish Larvae Phenotypic Screen
Ye Hong,
Christel Sourander,
Benjamin Hackl
et al.
Abstract:Current treatments for anxiety and depression show limited efficacy in many patients indicating that research into new underlying mechanisms is needed. Inhibition of JNK1 has been shown to evoke an anxiolytic-and antidepressant-like phenotype in mice however the downstream effectors that elicit these behavioural effects are unknown. Here we employ a zebrafish (D. Rerio) larvae behavioural assay to identify an antidepressant-/anxiolytic-like phenotype based on 2759 measured stereotypic responses to clinically p… Show more
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