2021
DOI: 10.1182/bloodadvances.2020002702
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JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

Abstract: Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl hydroxylase has been investigated extensively in hematopoiesis, the functional significance of other members of the 2-oxoglutarate (2-OG)-dependent protein hydroxylase family of enzymes remains poorly defined in HSC biology and multilineage hematopoiesis. Here, by using hematopoiet… Show more

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Cited by 10 publications
(9 citation statements)
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“…5 d). Among these proteins Jmjd6, Pik3ap1 and Samsn1 play a role in the regulation of B lymphopoiesis, including B cell differentiation, activation and B cell receptor signaling [ [52] , [53] , [54] ]. To test the functional effect of the Denr-Mcts1 complex in fetal HSPCs, we used CRISPR-Cas9 to delete Denr ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…5 d). Among these proteins Jmjd6, Pik3ap1 and Samsn1 play a role in the regulation of B lymphopoiesis, including B cell differentiation, activation and B cell receptor signaling [ [52] , [53] , [54] ]. To test the functional effect of the Denr-Mcts1 complex in fetal HSPCs, we used CRISPR-Cas9 to delete Denr ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Since histone arginine methylations are generally associated with transcriptional activation [ 27 , 28 , 29 , 30 ]. Indeed, JMJD6 promotes self-renewal of hematopoietic stem cells and adipose-derived mesenchymal stem cells [ 31 , 32 ]. Interestingly, Jmjd6 may regulates gene expression by integrating with chromatin [ 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…CFC assays were carried out using MethoCult TM M3434 (STEMCELL Technologies) methylcellulose medium ( Lawson et al, 2021a , b ). Two technical replicates were used per each biological replicate in each experiment.…”
Section: Methodsmentioning
confidence: 99%