JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis

Chen, Siyuan; Wang, Manni; Lu, Tianqi; Liu, Yu; Hong, Weiqi; He, Xuemei; Cheng, Yuan; Liu, Jian; Wei, Yuquan; Wei, Xiawei

doi:10.1038/s41388-023-02781-9

Cited by 14 publications

(3 citation statements)

References 45 publications

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“…Then, what is the role of JMJD6? JMJD6 can promote apoptosis and autophagy by protein demethylation and hydroxylation in cancers and vascular diseases [38,39], which might account for the role in cancer cells and atherosclerotic plaque.…”

Section: Discussionmentioning

confidence: 99%

JMJD6 Autoantibodies as a Potential Biomarker for Atherosclerosis-Related Diseases

Zhang,

Ito

et al. 2024

Preprint

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Atherosclerosis is associated with vascular diseases, diabetes, and cancers. The Jumonji C-domain-containing 6 (JMJD6) gene plays an important role in diverse biological processes. In addition, autoantibodies are reportedly useful in the early diagnosis and treatment of many diseases. Here, JMJD6 was identified by serological identification of antigens by recombinant cDNA expression cloning as an antigen recognized by serum IgG from patients with unstable angina pectoris. Then, we performed amplified luminescent proximity homogeneous assay-linked immunosorbent assay using purified recombinant antigens and found elevated levels of serum anti-JMJD6 antibodies (s-JMJD6-Abs) in patients with atherosclerosis-related diseases including ischemic stroke, acute myocardial infarction (AMI), diabetes mellitus (DM), and cancers including esophageal cancer (EC), gastric cancer, lung cancer, and mammary cancer, compared with those in healthy donors. The s-JMJD6-Ab levels were closely associated with hypertension, habitual smoking, and the intima-media thickness, an atherosclerosis index. The better postoperative survival status was shown in patients with EC from the JMJD6-Ab-positive group than the negative group, especially from JMJD6-Ab-positive/PD-L1-negative group and JMJD6-Ab-positive/p53-Ab-negative group than JMJD6-Ab-negative/PD-L1-positive group and JMJD6-Ab-negative/p53-Ab-positive group, respectively. Hence, JMJD6 autoantibodies may reflect atherosclerosis severity, thereby a potential biomarker for atherosclerosis-related diseases including ischemic stroke, AMI, DM, and cancers and for predicting EC prognosis.

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Section: Discussionmentioning

confidence: 99%

JMJD6 Autoantibodies as a Potential Biomarker for Atherosclerosis-Related Diseases

Zhang,

Ito

et al. 2024

Preprint

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“…[98] Overexpression of TCF21 promoted the polarization of TAMs to M1 macrophages and the enhancement of T cells activity by macrophages, which provided a new target for the treatment of lung cancer, [99] and JMJD6/STAT3/IL-10 axis which mediates the TAMs activation. [86] Finally, some small molecule drugs also show activities on TAMs. Pexidartinib (PLX) is an FDA-approved small molecule drug with significant TAM selectivity that blocks the CSF1 receptor on TAM, thereby inhibiting the proliferation of TAM.…”

Section: Implications Of Tams In Lung Cancer Immunotherapymentioning

confidence: 99%

The Biological Role of Macrophage in Lung and Its Implications in Lung Cancer Immunotherapy

Wang,

Gao,

et al. 2024

Advanced Biology

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The lungs are the largest surface of the body and the most important organ in the respiratory system, which are constantly exposed to the external environment. Tissue Resident Macrophages in lung constitutes the important defense against external pathogens. Macrophages connects the innate and adaptive immune system, and also plays important roles in carcinogenesis and cancer immunotherapy. Lung cancer is the leading cause of cancer‐related death worldwide, with an overall five‐year survival rate of only 21%. Macrophages that infiltrate or aggregate in lung tumor microenvironment are defined as tumor‐associated macrophages (TAMs). TAMs are the main components of immune cells in the lung tumor microenvironment. The differentiation and maturation process of TAMs can be roughly divided into two different types: classical activation pathway produces M1 tumor‐associated macrophages, and bypass activation pathway produces M2 tumor‐associated macrophages. Studies have found that TAMs are related to tumor invasion, metastasis, and treatment resistance, and show potential as a new target for tumor immunotherapy. Therefore, the biological function of macrophages in lung and the role of TAMs in the occurrence, development, and treatment of lung cancer are discussed in this paper.

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“…In contrast to the proinflammatory M1 phenotype, M2 macrophages, also known as alternatively activated or anti‐inflammatory macrophages, are induced by exposure to cytokines such as IL‐4 and IL‐13 and immunomodulatory molecules like glucocorticoids and IL‐10. 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 M2 macrophages are characterized by the expression of specific surface markers, including CD163 and CD206 (mannose receptor), and the production of anti‐inflammatory cytokines and mediators involved in tissue repair and homeostasis. 74 , 75 , 76 , 77 Key markers and functions of M2 macrophages include (a) anti‐inflammatory cytokine production : M2 macrophages secrete high levels of anti‐inflammatory cytokines such as IL‐10 and TGF‐β, which help to dampen the inflammatory response and promote tissue repair.…”

Section: Macrophage Plasticity: From Historical Origins To Contempora...mentioning

confidence: 99%

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

Yan,

Wang,

Cai

et al. 2024

MedComm

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Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically. Here, we provide a comprehensive overview of the signaling cascades governing macrophage plasticity, focusing on the roles of Toll‐like receptors, signal transducer and activator of transcription proteins, nuclear receptors, and microRNAs. We also discuss the emerging concepts of macrophage metabolic reprogramming and trained immunity, contributing to their functional adaptability. Macrophage plasticity plays a pivotal role in tissue repair and regeneration, with macrophages coordinating inflammation, angiogenesis, and matrix remodeling to restore tissue homeostasis. By harnessing the potential of macrophage plasticity, novel therapeutic strategies targeting macrophage polarization could be developed for various diseases, including chronic wounds, fibrotic disorders, and inflammatory conditions. Ultimately, a deeper understanding of the molecular mechanisms underpinning macrophage plasticity will pave the way for innovative regenerative medicine and tissue engineering approaches.

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JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis

Cited by 14 publications

References 45 publications

JMJD6 Autoantibodies as a Potential Biomarker for Atherosclerosis-Related Diseases

JMJD6 Autoantibodies as a Potential Biomarker for Atherosclerosis-Related Diseases

The Biological Role of Macrophage in Lung and Its Implications in Lung Cancer Immunotherapy

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

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