JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats

Wong-Guerra, Maylin; Montano-Peguero, Yanay; Ramírez-Sánchez, Jeney; Jimenez-Martin, Javier; Fonseca-Fonseca, Luis Arturo; Hernández-Enseñat, Daniela; Nonose, Yasmine; Valdés, Odalys; Mondelo-Rodriguez, Abel; Ortiz-Miranda, Yaquelin; Bergado, Gretchen; Carmenate, Tania; Valle, Roberto Menéndez Soto del; Pardo-Andreu, Gilberto L.; Outeiro, Tiago F.; Padrón-Yaquis, Alejandro Saúl; Assis, Adriano Martimbianco de; Souza, Diogo Onofre Gomes de; Nuñez-Figueredo, Yanier

doi:10.1016/j.neuro.2021.08.017

Cited by 14 publications

(5 citation statements)

References 98 publications

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“…This holds particularly true in settings that are polluted with diverse chemical substances. Metal ions have been found to have an impact on the enzyme acetylcholinesterase (AChE), however, the conclusions of these studies have been inconsistent (Romani et al, 2003;Wong-Guerra et al, 2021;Zatta et al, 2003). Researches have demonstrated that being exposed to organophosphate and carbamate pesticides can result in the suppression of AChE activity in both controlled experiments and factual conditions (Zheng et al, 2013;Wu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Biological monitoring of Soil pollution caused by two different Zinc species using earthworms

Singh,

Malla,

Kumar

et al. 2024

Preprint

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Zinc oxide nanoparticles (ZnO-NPs) are frequently employed in both commercial and agricultural sectors. Consequently, it is imperative to evaluate their impact on the soil ecosystem to ensure their safe and sustainable utilization in the long term. Earthworms are often used as a first indicator of soil pollution to monitor various pollutants. Nevertheless, there are unavoidable impediments that emerge during monitoring contamination in practical situations. To address the challenges, the study used soil bioindicator earthworm species Eudrilus eugeniae as an experimental model to evaluate the effects of two zinc species (ZnO-NPs and ZnCl2) on survival, reproduction, neuro-biomarkers, avoidance behavior, and their accumulation. The highest avoidance percentage was recorded 27.5% for ZnO-NP exposure and 37.5% for ZnCl2 exposure at 750 mg kg-1. ZnCl2 exposure decreased juvenile production by 3.00 ± 1.73 compared to 4.67 ± 1.15 for ZnO-NPs. At 750 mg kg−1, soils containing ZnCl2 (63.3%) had worse survival than those with ZnO-NPs (53.3%) administered, likely due to higher Zn ion. The bioaccumulation of nanoparticles and zinc ions adversely affect earthworm reproduction by reacting unfavourably with the neurotoxic marker AChE. Nevertheless, earthworms exposed to ZnCl2 had less Zn build-up in their gastrointestinal tracts than those exposed to NPs. The present work contradicts the finding that ZnO-NPs have hazardous effects on soil organisms. Instead, the study found that the toxicity of ZnCl2 was higher than that of ZnO-NPs. This difference in toxicity may be attributed to the ionic forms of Zn rather than its size. The study is valuable for ensuring the secure and sustainable application of ZnO-NPs.

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Section: Discussionmentioning

confidence: 99%

Biological monitoring of Soil pollution caused by two different Zinc species using earthworms

Singh,

Malla,

Kumar

et al. 2024

Preprint

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“…Of note, benzothiazepines like diazepam are GSK‐3β allosteric inhibitors that influence β‐catenin activity (Shri et al, 2023). The JM‐20, a BDZ derivative, protects against neuronal damage and counteracts cognitive and memory impairments by normalizing phosphorylated GSK‐3β (Wong‐Guerra et al, 2021). Treatment by 2,3‐BDZ derivatives, rather than the classical 1,4‐BDZ, increases hippocampal proliferation and synaptic transmission, which may improve cognitive performance (Carli et al, 2020).…”

Section: Psychotropic Drugs and Neurogenesismentioning

confidence: 99%

Influence of β‐catenin signaling on neurogenesis in neuropsychiatric disorders: Anxiety and depression

El‐Kadi,

AbdelKader,

Zaki

et al. 2024

Drug Development Research

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It has been proven that stress, mainly in the early years of life, can lead to anxiety and mood problems. Current treatments for psychiatric disorders are not enough, and some of them show intolerable side effects, emphasizing the urgent need for new treatment targets. Hence, a better understanding of the different brain networks, which are involved in the response to anxiety and depression, may evoke treatments with more specific targets. One of these targets is β‐catenin that regulates brain circuits. β‐Catenin has a dual response toward stress, which may influence coping or vulnerability to stress response. Indeed, β‐catenin signaling involves several processes such as inflammation‐directed brain repair, inflammation‐induced brain damage, and neurogenesis. Interestingly, β‐catenin reduction is accompanied by low neurogenesis, which leads to anxiety and depression. However, in another state, this reduction activates a compensatory mechanism that enhances neurogenesis to protect against depression but may precipitate anxiety. Thus, understanding the molecular mechanism of β‐catenin could enhance our knowledge about anxiety and depression's pathophysiology, potentially improving clinical results by targeting it. Herein, the different states of β‐catenin were discussed, shedding light on possible drugs that showed action on psychiatric disorders through β‐catenin.

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“…Radiation induced aging models are usually used in cancer treatment (radiotherapy) related aging researches ( 29 ). Application of β-amyloid and aluminum chloride induces brain disorders, and these models are usually applied in Alzheimer's Disease related studies ( 30 , 31 ). In recent years, transgenic aging models gain more and more attention with the development of gene editing technologies.…”

Section: Aging Liver: Suitable Animal Modelsmentioning

confidence: 99%

Understanding the Unique Microenvironment in the Aging Liver

Zhao

Yang

et al. 2022

Front. Med.

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In the past decades, many studies have focused on aging because of our pursuit of longevity. With lifespans extended, the regenerative capacity of the liver gradually declines due to the existence of aging. This is partially due to the unique microenvironment in the aged liver, which affects a series of physiological processes. In this review, we summarize the related researches in the last decade and try to highlight the aging-related alterations in the aged liver.

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JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats

Cited by 14 publications

References 98 publications

Biological monitoring of Soil pollution caused by two different Zinc species using earthworms

Biological monitoring of Soil pollution caused by two different Zinc species using earthworms

Influence of β‐catenin signaling on neurogenesis in neuropsychiatric disorders: Anxiety and depression

Understanding the Unique Microenvironment in the Aging Liver

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