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Koval'skaya, N. E.; Kuznetsova, Nina A.; Kaliya, O. L.; Gretsova, N. S.; Соколова, И. В.

doi:10.1023/a:1019272320749

Journal of Applied Spectroscopy

2001

DOI: 10.1023/a:1019272320749

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N. E. Koval'skaya¹,

Nina A. Kuznetsova

O. L. Kaliya

et al.

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Cited by 3 publications

(2 citation statements)

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“…However, sometimes the combined action of light and the photosensitizer causes positive therapeutic effects. Photochemotherapy methods have been devised based on such combination effects of light and dyes on the human body.A number of substances from this group of compounds have properties enabling their use in photochemotherapy of various skin diseases (psoriasis, atopic dermatitis, rheumatoid arthritis, vitiligo) [6,7]. Many substituted coumarins display anticoagulant activity, which is used for therapy of thromboses.…”

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Fluorescent characteristics of coumarin photosensitizers

et al. 2008

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We present a theoretical and experimental study of the fluorescent ability of new coumarin sensitizers. Using the INDO method, we have drawn the level diagram for the photophysical processes in the coumarin molecules. We have calculated the rate constants for internal conversion and intersystem crossing and the radiative rate constants. We have determined the experimental and theoretical fluorescence yields of the test compounds.Introduction. Coumarins are a group of organic dyes in the blue-green range. These compounds are widely used in different fields of science and technology. For example, many coumarins exhibit intense fluorescence, which is used to design fluorescent labels, optical brighteners, laser active media, and organic light-emitting diodes [1,2]. At the same time, a change in structure can lead to creation of coumarins having good photosensitizing properties.Furocoumarins (psoralenes) are heterocyclic aromatic compounds having photosensitizer properties in the UV radiation range, 320-400 nm [3]. Usually photosensitization is an undesirable phenomenon [4,5], leading to light-induced burns on the skin and eyes for low exposure doses which, under ordinary conditions, do not have a damaging effect. However, sometimes the combined action of light and the photosensitizer causes positive therapeutic effects. Photochemotherapy methods have been devised based on such combination effects of light and dyes on the human body.A number of substances from this group of compounds have properties enabling their use in photochemotherapy of various skin diseases (psoriasis, atopic dermatitis, rheumatoid arthritis, vitiligo) [6,7]. Many substituted coumarins display anticoagulant activity, which is used for therapy of thromboses. In recent years, compounds in this class have also begun to be used for photoinduced modification of nucleic acids, for phototherapy of cancer and viral infections (including HIV infections), and also in transplantology to prevent rejection of transplanted tissues. Despite their widespread popularity, this class of compounds still remains poorly studied.Some compounds in the substituted coumarin series act as bifunctional photoreagents, capable of crosslinking both DNA strands [5,8]. Besides photoreactions of furocoumarins with DNA to form adducts (type III reactions), other types of photochemical reactions are possible [9]. For structurally different furocoumarins, the ratio of the contributions of the different types of photoreactions may vary significantly. The increasingly expanding use of furocoumarins as photosensitizers and photoreagents urgently requires determining the relationship between their structure, spectral luminescence properties, and the primary photoprocesses occurring in them. We may hypothesize that it is specifically the spectral luminescence and photophysical properties and their dependence on the structure of the compound that to a significant extent will determine the later course of both photochemical and photobiological processes, since they all occur with partici...

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confidence: 99%

“…A number of substances from this group of compounds have properties enabling their use in photochemotherapy of various skin diseases (psoriasis, atopic dermatitis, rheumatoid arthritis, vitiligo) [6,7]. Many substituted coumarins display anticoagulant activity, which is used for therapy of thromboses.…”

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confidence: 99%

Fluorescent characteristics of coumarin photosensitizers

et al. 2008

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Glycophthalocyanines as Photosensitizers for Triggering Mitotic Catastrophe and Apoptosis in Cancer Cells

Soares

Neves

Tomé

et al. 2012

Chem. Res. Toxicol.

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Photodynamic therapy (PDT) is a treatment modality for different forms of cancer based on the combination of light, molecular oxygen, and a photosensitizer (PS) compound. When activated by light, the PS generates reactive oxygen species leading to tumor destruction. Phthalocyanines are compounds that have already shown to be efficient PSs for PDT. Several examples of carbohydrate substituted phthalocyanines have been reported, assuming that the presence of carbohydrate moieties could improve their tumor selectivity. This work describes the photoeffects of symmetric and asymmetric phthalocyanines with D-galactose (so-called GPh1, GPh2, and GPh3) on HeLa carcinoma cells and their involvement in cell death. Photophysical properties and in vitro photodynamic activities for the compounds considered revealed that the asymmetric glycophthalocyanine GPh3 is very efficient and selective, producing higher photocytotoxicity on cancer cells than in nonmalignat HaCaT. The cell toxiticy after PDT treatment was dependent upon light exposure level and GPh3 concentration. GPh3 causes cell cycle arrest at the metaphase stage leading to multiple spindle poles, mitotic catastrophe, followed by apoptosis in cancer cells. These effects were partially negated by the pancaspase inhibitor Z-VAD-FMK. Together, these results indicate that GPh3 is an excellent candidate drug for PDT, able to induce selective tumor cell death.

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Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

Stuchinskaya

Moreno

Cook

et al. 2011

Photochem Photobiol Sci

308

221

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Cited by 3 publications

References 5 publications

Fluorescent characteristics of coumarin photosensitizers

Fluorescent characteristics of coumarin photosensitizers

Glycophthalocyanines as Photosensitizers for Triggering Mitotic Catastrophe and Apoptosis in Cancer Cells

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

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