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Trewin, V. F.; Lawrence, C. J.; Abdulla, Alan; Pearce, V.; Veitch, G. B. A.; Roach, Mary Joan

doi:10.1023/a:1008669826178

Cited by 7 publications

(1 citation statement)

References 11 publications

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“…12 The reported prevalence of antidepressant use among PD patients ranges from 1.9% to 43.2%. [13][14][15][16][17][18][19][20][21][22] This variation might be explained by differences in the time period under study. For example, studies conducted in the early 1990s have tended to report a lower prevalence of antidepressant use, such as 13.19% in Norway in 1992 (20) and 1.9% in US nursing homes from 1992 to 1996.…”

Section: Introductionmentioning

confidence: 99%

Impact of Antidepressants on Cardiac Events and All-Cause Mortality in Parkinson’s Disease: A National Data-Linkage Study

Orayj

2021

NDT

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Purpose This study investigated the 1-year risk of ischemic heart disease (IHD), all cardiovascular events, and all-cause mortality among newly diagnosed Parkinson’s disease (PD) patients who used antidepressants compared to those who did not. Patients and Methods Patients with PD aged 40 years or older were identified using data from 2000 through 2016 held within the Welsh Secure Anonymized Information Linkage (SAIL) databank. Antidepressant users were propensity-score matched 1:1 with non-users, adjusting for patients’ demographics, socioeconomic status, and multiple comorbidities. Cox proportional hazard regression analyses were performed to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between the antidepressants and the study outcomes. The follow-up period was 1 year after the initial prescription of antidepressants. Results The study group comprised a total of 3364 participants, with numbers split equally between the antidepressant-user and non-user groups, based on the propensity score-matching process. Overall, the propensity score-adjusted model showed that antidepressant usage in PD patients was not significantly associated with the risk of IHD (HR = 1.05; 95% CI 0.63–1.75) or all cardiovascular events (HR = 1.01; 95% CI 0.71–1.45) compared to non-users. The propensity score-adjusted model also showed that the use of any antidepressant, regardless of its category, was not statistically significantly associated with all-cause mortality (HR = 0.81; 95% CI 0.65–1.02). However, this association reached statistical significance in the multivariate adjusted model (HR = 0.67; 95% CI 0.54–0.84). Conclusion There was no evidence that antidepressant use was associated with an increased risk of IHD or all cardiovascular events in newly diagnosed PD patients who suffered from depression. Furthermore, antidepressant use might reduce the mortality rate in PD patients during the first year after initiation.

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Section: Introductionmentioning

confidence: 99%

Impact of Antidepressants on Cardiac Events and All-Cause Mortality in Parkinson’s Disease: A National Data-Linkage Study

Orayj

2021

NDT

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Psychotic and compulsive symptoms in Parkinson's disease

Verbaan¹,

Rooden²,

Visser³

et al. 2009

Movement Disorders

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The objective of this study is to evaluate psychiatric symptoms in Parkinson's disease (PD) patients and to assess their relation with other clinical aspects of PD. Psychotic symptoms (PS) and compulsive symptoms (CS) as well as other nonmotor and motor features were evaluated in 353 PD patients. Psychotic and compulsive symptom scores did not correlate significantly. PS occurred in 65% of patients, with item frequencies ranging from 10% (paranoid ideation) to 55% (altered dream phenomena). Regression analysis showed that autonomic impairment accounted for 20% of the 32% explained variance of PS, whereas cognitive problems, depression, daytime sleepiness, and dopamine agonist (DA) dose explained the rest. CS occurred in 19%, with item frequencies of 10% for both sexual preoccupation and compulsive shopping/gambling. Patients with more severe CS (score > or = 2 on one or both items) were significantly more often men, had a younger age at onset, a higher DA dose and experienced more motor fluctuations compared to the other patients. PS and CS are common but unrelated psychiatric symptoms in PD. The relations found between PS and cognitive problems, depression, daytime sleepiness, and autonomic impairment suggests a resemblance with Dementia with Lewy Bodies. The prominent association between PS and autonomic impairment may be explained by a shared underlying mechanism. Our results confirm previous reports on the profile of patients developing CS, and mechanisms underlying motor fluctuations may also play a role in the development of CS in PD.

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Drug prescribing patterns in Parkinson's disease: a pharmacoepidemiological survey in a cohort of ambulatory patients

Leoni

Martignoni

Cosentino

et al. 2002

Pharmacoepidemiology and Drug

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In IPD patients, disease duration and severity and patient age seem to be major determinants of drug use. Indications for drug prescription suggest that main comorbidity includes neuropsychiatric, circulatory, musculoskeletal and digestive disorders. Analysis of prescribing patterns in IPD can provide a readily accessible indirect indicator of patient health status for both health services and epidemiologic research purposes.

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Untitled

Cited by 7 publications

References 11 publications

Impact of Antidepressants on Cardiac Events and All-Cause Mortality in Parkinson’s Disease: A National Data-Linkage Study

Impact of Antidepressants on Cardiac Events and All-Cause Mortality in Parkinson’s Disease: A National Data-Linkage Study

Psychotic and compulsive symptoms in Parkinson's disease

Drug prescribing patterns in Parkinson's disease: a pharmacoepidemiological survey in a cohort of ambulatory patients

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