Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

He, Hailang; Wang, Dan; Tang, Jie; Zhou, Xianmei; Li, Jianxin; Xu, Ling

doi:10.1155/2016/3635209

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…He et al provided an experimental evidence that Jinfukang suppressed the differentiation and migration of lymphatic endothelial cells (LECs) in vitro, which is closely related to the tumor lymph-angiogenesis. This inhibitory effect might be via regulation of stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) and vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 (VEGFR)-3 axes [ 55 ]. Que et al elucidated that Jingfukang can induce DNA damage in circulating tumor cell (CTC)-TJH-01 cells through the ROS-mediated ataxia telangiectasia mutated (ATM)/ATM and Rad3-related (ATR)-p53 signaling pathway.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the other study used JFK-containing serums which were prepared from JFK-dosed rats and applied to the in vitro assays. Using serum drug concentration might directly reflect the drug efficacy since crude herbal medicine exhibit complex compositions and need series of biotransformation before performing their pharmacological actions [ 55 ]. As with experiment methods, there were seven in vitro studies while the other nine used both the in vitro and in vivo.…”

Section: Resultsmentioning

confidence: 99%

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Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

et al. 2021

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Metastasis is the main cause of cancer-related death. Despite its high fatality, a comprehensive study that covers anti-metastasis of herbal medicines has not yet been conducted. The aim of this study is to investigate and assess the anti-metastatic efficacies of herbal medicines in the five major cancers, including lung, colorectal, gastric, liver, and breast cancers. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “cancer metastasis” and “herbal medicine” as keywords. Correspondingly, 16 lung cancer, 23 colorectal cancer, 10 gastric cancer, 10 liver cancer, and 18 breast cancer studies were systematically reviewed. The herbal medicines attenuated metastatic potential targeting various mechanisms such as epithelial mesenchymal transition (EMT), reactive oxygen species (ROS), and angiogenesis. Specifically, the drugs regulated metastasis related factors such as matrix metalloproteinase (MMP), serine-threonine protein kinase/extracellular regulated protein kinase (AKT/ERK), angiogenic factors, and chemokines. Overall, the present study is the first review, comprehensively investigating the anti-metastasis effect of herbal medicines on five major cancers, providing the experimental models, doses and durations, and mechanisms. Herbal medicines could be a potent candidate for anti-metastatic drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

et al. 2021

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“…Previous studies have demonstrated that Jingfukang can promote DDP-induced apoptosis in lung cancer cells [21, 22]. In addition, other studies have also found that Jinfukang can inhibit lymphatic endothelial cell formation and migration and inhibit the lung tumor mass via the suppression of bone marrow-derived mesenchymal stem cell transformation and lung tumor lymphangiogenesis [23, 24].…”

Section: Discussionmentioning

confidence: 99%

Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells

Que

Zhou

Luo

et al. 2019

BMC Complement Altern Med

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Background Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been clinically available for the treatment of non-small cell lung cancer (NSCLC). In this study, we investigated the action and underlying mechanisms of Jinfukang against circulating lung tumor cells. Methods The cell counting kit-8 (CCK-8), colony formation and cell cycle assays were used to study the cell proliferation ability. Flow cytometry was used to detect the apoptosis and the expression level of ROS and Caspase-3. Comet and TUNEL assays were used to detect DNA damage. DNA damage related pathway protein was detected by western blot. Results Jinfukang significantly inhibits the proliferation of CTC-TJH-01 cells by inducing G1 phase arrest and inhibits their colony formation in a dose-dependent manner. Moreover, Jinfukang induces apoptosis in CTC-TJH-01 cells through the ROS-mediated ATM/ATR-p53 pathway and DNA damage. Conclusions Our findings suggest that Jinfukang may be a potential drug for lung cancer metastasis. Electronic supplementary material The online version of this article (10.1186/s12906-019-2601-x) contains supplementary material, which is available to authorized users.

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“…Given that traditional Chinese medicine is composed of multiactive components and possesses multitarget action feature, it can aim at multiple targets, exerting a systemic effect at the same time. Multitarget medicine has been proven to be particularly effective in treating complex diseases [ 1 , 27 – 29 ]. In this study, we found that FYC protected articular cartilage via numerous ways, including the reduction of ECM degradation factors, decrease in inflammatory mediator depression, and improvement of articular cartilage protective factor.…”

Section: Discussionmentioning

confidence: 99%

Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model

Zeng

Xiao

Deng

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Fu Yuan Capsule (FYC) has been clinically used for osteoarthritis (OA) and its related diseases for many years in China. However, its pharmacological mechanism remains unclear. This study aimed to investigate the potential chondroprotective effects of FYC on articular cartilage. Rat OA model was induced by anterior cruciate ligament transection. A group of rats was treated with FYC for 12 weeks. Joint structure, types I and II collagen, and proteoglycan were evaluated by histological examination. The expression of C-terminal crosslinking telopeptide of type II collagen, hydroxyproline, a disintegrin and metalloproteinase with thrombospondin motifs, matrix metalloproteinase, interleukin-1 beta, nitric oxide, prostaglandin E2, heat-shock protein 70, transforming growth factor-beta, osteoprotegerin, and receptor activator of nuclear factor κB ligand were detected. Treatment with FYC could protect against articular cartilage injury. FYC treatment significantly decreased the extracellular matrix degradation factors and inflammatory mediators. Moreover, articular cartilage protective factors were increased in the FYC group. The current finding suggests that FYC protects articular cartilage in a rat OA model through various ways. Thus, it may be an effective agent for OA treatment.

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Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration

Cited by 4 publications

References 29 publications

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery

Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells

Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model

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