JianPiYiShen formula prevents cisplatin-induced acute kidney injury in mice by improving necroptosis through MAPK pathway
Zhongtang Li,
Riming He,
Jiahui Liu
et al.
Abstract:Background
Acute kidney injury (AKI), characterized by necroptosis and activation of MAPK pathway, causes sudden declines in renal function. To date, efficacious treatments are lacking. JianPiYiShen Formula (JPYSF) has a protective effect on the kidneys. The aim of this study is to explore the mechanism of JPYSF in cisplatin-induced AKI.
Methods
Male C57/BL6J mice were divided into control group, cisplatin group and cisplatin + JPYSF group. Before … Show more
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