Jianpi Bushen, a Traditional Chinese Medicine Therapy, Combined with Chemotherapy for Gastric Cancer Treatment: A Meta-Analysis of Randomized Controlled Trials

Chen, Yunbo; Zhang, Guijuan; Chen, Xiaoping; Jiang, Xuefeng; Bie, Fengjie; Yuan, Naijun; Wang, Yurong; Hao, Xinchang; Ma, Min

doi:10.1155/2018/4924279

Cited by 14 publications

(15 citation statements)

References 5 publications

(7 reference statements)

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“…According to these findings, we can infer that when treating GC using paclitaxel-based chemotherapy combined with TCMs, most of the studies invigorated the qi and strengthened the spleen as the standard treatment approach. This is also supported by the existing evidence on TCM treatment for advanced GC and TCMs combined with chemotherapy (Chen et al, 2018). In addition, we found a frequently recurring combination of eight ingredients (Dangshen, Gancao, Baizhu, Fuling, Chenpi, Shanyao, Yiyiren, and Sharen).…”

Section: Et Al Integrative Gastric Cancer Therapiessupporting

confidence: 88%

Meta-Analysis of Paclitaxel-Based Chemotherapy Combined With Traditional Chinese Medicines for Gastric Cancer Treatment

Sui

et al. 2020

Front. Pharmacol.

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This study aimed to compare the efficacy and safety of traditional Chinese medicines (TCMs) combined with paclitaxel-based chemotherapy and paclitaxel-based chemotherapy alone for gastric cancer treatment. Literature searches (up to September 25, 2019) were performed using the Cochrane Library, EMBASE, PubMed, Chinese Science and Technology Journals (CQVIP), Wanfang, and China Academic Journals (CNKI) databases. Data from 14 randomized controlled trials (RCTs), with 1,109 participants, were included. The results indicated that, compared with paclitaxel-based chemotherapy alone, the combination of TCMs and paclitaxel-based chemotherapy significantly improved the tumor response rate (TRR; RR: 1.39; 95% CI: 1.24-1.57; p < 0.001, I 2 = 12%), increased the quality of life based on the Karnofsky Performance Scale score (RR: 1.53; 95% CI: 1.19-1.96; p < 0.001, I 2 = 0%), and reduced the side effects, such as neutropenia (RR: 0.68; 95% CI: 0.55-0.84; p < 0.001, I 2 = 44%), leukopenia (RR: 0.69; 95% CI: 0.54-0.90; p < 0.01, I 2 = 40%), thrombocytopenia (RR: 0.66; 95% CI: 0.46-0.96; p < 0.05, I 2 = 32%), and nausea and vomiting (RR: 0.50; 95% CI: 0.32-0.80; p < 0.01, I 2 = 85%). Hepatic dysfunction (RR: 0.63; 95% CI: 0.33-1.20; p = 0.16, I 2 = 0%), neurotoxicity (RR: 0.64; 95% CI: 0.26-1.55; p = 0.32, I 2 = 0%), and anemia (RR: 0.65; 95% CI: 0.40-1.04; p = 0.07, I 2 = 0%) were similar between the two groups. Evidence from the meta-analysis suggested that compared with paclitaxelbased chemotherapy alone, the combination of TCMs and paclitaxel-based chemotherapy may increase the TRR, improve quality of life, and reduce multiple chemotherapy-related side effects in gastric cancer patients. Additional rigorously designed large RCTs are required to confirm the efficacy and safety of this treatment.

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Section: Et Al Integrative Gastric Cancer Therapiessupporting

confidence: 88%

Meta-Analysis of Paclitaxel-Based Chemotherapy Combined With Traditional Chinese Medicines for Gastric Cancer Treatment

Sui

et al. 2020

Front. Pharmacol.

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“…China's increasing demand for donkey hides has been triggered mainly by the increased demand for ejiao, a traditional Chinese medicine that is widely preferred for health care. Some of the uses of ejiao include as an ingredient for lifestyle products [28], for the medicinal purposes used to improve blood circulation and cure blood diseases such as anemia and low blood cell counts [29], menopausal syndrome, and gastric cancer [30,31].…”

Section: Demand For Donkey and Donkey Hides In Chinamentioning

confidence: 99%

Telecoupling of the Trade of Donkey-Hides between Botswana and China: Challenges and Opportunities

Matlhola

Chen

2020

Sustainability

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International trade has become a major threat to biodiversity in the telecoupled world. The literature on biodiversity loss mostly concentrates on wild species; however, the increasing loss of and demand for domesticated species are overlooked. Donkeys are decreasing in many countries because of economic development, urbanization, and increased demand for donkey hides in China. The donkey population in Africa has rapidly declined recently due to supplying China with donkey hides for the production of highly demanded and legalized traditional medicine, ejiao. As a result, some African countries, including Botswana, banned the export of donkey hides. Animal protection and media continuously reported threats over the extinction of donkeys and exacerbated rural livelihood in developing countries, however, limited literature has investigated the causes and effects of donkey-hide trade and its policy interventions. This paper applies the telecoupling framework and uses the data extracted from the media reports and FAO, to understand the scale and impacts of donkey-hide trade from Botswana to China. We also explore the challenges and opportunities of donkey-hide trade for Botswana, highlighting the mechanisms need to be established to regulate the donkey-hide trade, and also to harness available opportunities if the trade ban is lifted in the future.

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“…Since chemotherapeutics have the insurmountable problems of multidrug resistance and adverse effects (such as fatigue, anemia, vomiting, decreased neutrophils, thrombocytopenia, diarrhea, and nausea), and resection or radical surgery can cause surgical trauma, malnutrition, and other complications, the quality of life and 5-year overall survival rate for GC patients remain low. In China, Chinese herbal medicines, due to clear curative effects and low toxicity, are increasingly used as alternative and complementary approaches for the prevention and treatment of gastric cancer [21,22].…”

Section: Discussionmentioning

confidence: 99%

ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3K/AKT Pathway

Song

Jiao

et al. 2020

BioMed Research International

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In recent years, traditional Chinese medicine has played an important role in the treatment of gastric cancer in China. ZiYinHuaTan (ZYHT) recipe was developed for advanced gastric cancer and had shown its promising value in the clinic. In this study, we explore the effect of ZYHT on gastric cancer in vitro and in vivo. ZYHT can inhibit tumor growth and improve the general condition of mice in subcutaneous transplantation nude mice models of gastric cancer. And ZYHT can also inhibit cell proliferation and blocked the cells in G0/G1 to induce cell apoptosis in HGC27 and MGC803 cells. Then, network pharmacology analysis showed that ZYHT may exert antitumor effect mainly through PI3K/AKT signaling pathway. Furthermore, the expression of PI3K, p-Akt, CyclinD1, and Bcl-2 was detected in vitro and in vivo. The results showed that ZYHT could decrease the expression of PI3K, CyclinD1, and Bcl-2 both in vitro and in vivo. These results suggested that ZYHT could be used as a method for the treatment of developed gastric cancer.

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Jianpi Bushen, a Traditional Chinese Medicine Therapy, Combined with Chemotherapy for Gastric Cancer Treatment: A Meta-Analysis of Randomized Controlled Trials

Cited by 14 publications

References 5 publications

Meta-Analysis of Paclitaxel-Based Chemotherapy Combined With Traditional Chinese Medicines for Gastric Cancer Treatment

Meta-Analysis of Paclitaxel-Based Chemotherapy Combined With Traditional Chinese Medicines for Gastric Cancer Treatment

Telecoupling of the Trade of Donkey-Hides between Botswana and China: Challenges and Opportunities

ZiYinHuaTan Recipe Inhibits Cell Proliferation and Promotes Apoptosis in Gastric Cancer by Suppressing PI3K/AKT Pathway

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