Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: A network pharmacology analysis based on multi-omics validation

Li, Chaoxiong; Lin, Xiangquan; Lin, Qin; Lin, Yanping; Lin, Haiming

doi:10.1016/j.phymed.2023.155137

Cited by 5 publications

(1 citation statement)

References 59 publications

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“…The integration of multi-omics data enables the identification of key regulatory pathways, biomolecular networks, and potential therapeutic targets that may not be evident from individual omics analyses alone [158][159][160]. For example, integrating proteomic and transcriptomic data can elucidate the relationship between gene expression and protein abundance, revealing post-transcriptional regulatory mechanisms in osteoporosis [133,161,162]. Similarly, the integration of proteomic and metabolomic data can uncover metabolic pathways dysregulated in osteoporosis and identify metabolic biomarkers associated with disease progression and fracture risk [146].…”

Section: Integration Of Multi-omic Data For a Holistic Understandingmentioning

confidence: 99%

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Wang,

Xue,

et al. 2024

Biomolecules

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Osteoporosis (OP), a prevalent skeletal disorder characterized by compromised bone strength and increased susceptibility to fractures, poses a significant public health concern. This review aims to provide a comprehensive analysis of the current state of research in the field, focusing on the application of proteomic techniques to elucidate diagnostic markers and therapeutic targets for OP. The integration of cutting-edge proteomic technologies has enabled the identification and quantification of proteins associated with bone metabolism, leading to a deeper understanding of the molecular mechanisms underlying OP. In this review, we systematically examine recent advancements in proteomic studies related to OP, emphasizing the identification of potential biomarkers for OP diagnosis and the discovery of novel therapeutic targets. Additionally, we discuss the challenges and future directions in the field, highlighting the potential impact of proteomic research in transforming the landscape of OP diagnosis and treatment.

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Section: Integration Of Multi-omic Data For a Holistic Understandingmentioning

confidence: 99%

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Wang,

Xue,

et al. 2024

Biomolecules

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Proteomics in orthopedic research: Recent studies and their translational implications

Li,

Stampas,

Komatsu

et al. 2024

Journal Orthopaedic Research

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Proteomics is a growing field that offers insights into various aspects of disease processes and therapy responses. Within the field of orthopedics, there are a variety of diseases that have a poor prognosis due to a lack of targeted curative therapy or disease modifying therapy. Other diseases have been difficult to manage in part due to lack of clinical biomarkers that offer meaningful insight into disease progression or severity. As an emerging technology, proteomics has been increasingly applied in studying bone biology and an assortment of orthopedics related diseases, such as osteoarthritis, osteosarcoma and bone tumors, osteoporosis, traumatic bone injury, spinal cord injury, hip and knee arthroplasty, and fragile healing. These efforts range from mechanistic studies for elucidating novel insights in tissue activity and metabolism to identification of candidate biomarkers for diagnosis, prognosis, and targeted treatment. The knowledge gained from these proteomic and functional studies has provided unique perspectives in studying orthopedic diseases. In this review, we seek to report on the current state of the proteomic study in the field of orthopedics, overview the advances in clinically applicable discoveries, and discuss the opportunities that may guide us for future research.

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Jiawei Bai-Hu-decoction ameliorated heat stroke-induced brain injury by inhibiting TLR4/NF-κB signal and mitophagy of glial cell

Lin,

Hong,

Liu

et al. 2024

Journal of Ethnopharmacology

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Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: A network pharmacology analysis based on multi-omics validation

Cited by 5 publications

References 59 publications

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease

Proteomics in orthopedic research: Recent studies and their translational implications

Jiawei Bai-Hu-decoction ameliorated heat stroke-induced brain injury by inhibiting TLR4/NF-κB signal and mitophagy of glial cell

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