Jewish, Christian and Muslim theological perspectives about xenotransplantation

Paris, Wayne; Seidler, Rabbi Jerry H.; Fitzgerald, Kevin T.; Padela, Aasim I.; Cozzi, Emanuele; Cooper, D. K. C.

doi:10.1111/xen.12400

Cited by 60 publications

(65 citation statements)

References 26 publications

(57 reference statements)

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“…Given the reality of future clinical trials, it is important to explore how religious traditions might view XTx as a therapy, to better understand their theological views how each might address the importance of human health, and the use of pigs to bring health to others. A full understanding of the beliefs and practices of the Jewish, Christian, and Muslim traditions will be necessary to fully prepare for, and implement, clinical trials of XTx …”

Section: Discussionmentioning

confidence: 99%

Student nurses at Spanish universities and their attitude toward xenotransplantation

Martı́nez-Alarcón

Rı́os

Santainés‐Borredá

et al. 2019

Xenotransplantation

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Introduction: Recent immunological and transgenic advances are a promising alternative using limited materials of human origin for transplantation. However, it is essential to achieve social acceptance of this therapy.Objective: To analyze the attitude of nursing students from Spanish universities toward organ xenotransplantation (XTx) and to determine the factors affecting their attitude.Materials and methods: Type of study: A sociological, multicentre, and observational study. Study population: Nursing students enrolled in Spain (n = 28,000). Sample size:A sample of 10 566 students estimating a proportion of 76% (99% confidence and precision of ±1%), stratified by geographical area and year of study. Instrument of measurement: A validated questionnaire (PCID-XenoTx-RIOS) was handed out to every student in a compulsory session. This survey was self-administered and selfcompleted voluntarily and anonymously by each student in a period of 5-10 min.Statistical analysis: descriptive analysis, Student's t test, the chi-square test, and a logistic regression analysis.Results: A completion rate: 84% (n = 8913) was obtained. If the results of XTx were as good as in human donation, 74% (n = 6564) would be in favor and 22% (n = 1946) would have doubts. The following variables affected this attitude: age (P < 0.001); sex (P < 0.001); geographical location (P < 0.001); academic year of study (P < 0.001); attitude toward organ donation (P < 0.001); belief in the possibility of needing a transplant (P < 0.001); discussion of transplantation with one's family (P < 0.001) and friends (P < 0.001); and the opinion of one's partner (P < 0.001). The following variables persisted in the multivariate analysis: being a male (OR = 1.436; P < 0.001); geographical location (OR = 1.937; P < 0.001); an attitude in favor of donation (OR = 1.519; P < 0.001); belief in the possibility of needing a transplant (OR = 1.497; P = 0.036);and having spoken about the issue with family (OR = 1.351; P < 0.001) or friends (OR = 1.240; P = 0.001). Conclusions:The attitude of nursing students toward organ XTx is favorable and is associated with factors of general knowledge about organ donation and transplantation and social interaction. K E Y W O R D S attitude, knowledge, Organ xenotransplantation, student nurses 1 | INTRODUC TI ON Due to this organ shortage and the increase in the indications for transplantation, there are increasing numbers of patients on the waiting list with the mortality that this brings with it. 1 In the search for definitive solutions, there is continued research into xenotransplantation (XTx) in order to attempt to obtain an inexhaustible source of cells and organs. 2,3 Although clinical XTx is not a reality at present, in preclinical trials it has been possible to obtain a functioning pig-baboon model. 6 Therefore, in vital organs and in emergency situations, XTx could be used as a bridge while waiting for a human organ. 7,8

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Section: Discussionmentioning

confidence: 99%

Student nurses at Spanish universities and their attitude toward xenotransplantation

Martı́nez-Alarcón

Rı́os

Santainés‐Borredá

et al. 2019

Xenotransplantation

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“…Thus, saving human lives overrides the prohibition of using a porcine organ for transplantation [7]. First, many Islamic cultures do not allow the use of porcine organs, such as heart valves, to replace defective human organs.…”

Section: Ethical Concernsmentioning

confidence: 99%

“…First, many Islamic cultures do not allow the use of porcine organs, such as heart valves, to replace defective human organs. Catholic ethicists in Canada and the USA also favor xenotransplantation as long as the technology preserves human identity and precludes the use of aborted embryos as a source of human stem cells [7]. Thus, saving human lives overrides the prohibition of using a porcine organ for transplantation [7].…”

Section: Ethical Concernsmentioning

confidence: 99%

“…However, this issue might be mitigated by the views of several Islamic scholars who have allowed organ transplants from pigs because the patients would die without these transplants. Thus, saving human lives overrides the prohibition of using a porcine organ for transplantation [7]. For Jewish patients, porcine products cannot be used as food, but can be used as organ transplants [8].…”

Section: Ethical Concernsmentioning

confidence: 99%

“…Moreover, Judaism promotes xenotransplantation to prolong or save the life of a human being who is ill or dying from organ failure. Catholic ethicists in Canada and the USA also favor xenotransplantation as long as the technology preserves human identity and precludes the use of aborted embryos as a source of human stem cells [7]. These ethicists emphasize that pluripotent and not embryonic stem cells must be used in these protocols.…”

Section: Ethical Concernsmentioning

confidence: 99%

See 2 more Smart Citations

Ethical rejections of xenotransplantation?

Loike

Kadish

2018

EMBO Reports

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The importance of public engagement in clinical xenotransplantation

Hurst,

Cooper

2024

Health Care Science

Self Cite

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Over the past several decades, significant scientific progress in xenotransplantation has brought the field to the threshold of clinical trials. In the past 3 years in the United States, experimental pig kidney and heart xenotransplantation have been performed on human subjects recently declared dead by neurological criteria (decedents). In addition, two pig heart transplants have been carried out in living patients under the United States Food and Drug Administration's expanded access guidelines. However, though there has been a flurry of activity there remain unanswered questions regarding how the public views xenotransplantation, what concerns may exist, and how to address these concerns in a meaningful way. This paper aims to underscore the importance of public engagement in xenotransplantation, emphasizing the ongoing need for studies to assess public opinions. The current evidence on public engagement studies is reviewed and gaps in our understanding are identified. We propose practical steps to advance this field. Additional studies to determine the extent of racial/ethnic differences in attitudes to xenotransplantation should be conducted. Empirical and descriptive analysis of certain religious viewpoints—especially minority faiths—would be valuable. As public engagement is an important aspect of public acceptance of novel research that is accompanied by risk, we suggest that xenotransplantation biotechnology companies might consider leading the way in funding this research.

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Jewish, Christian and Muslim theological perspectives about xenotransplantation

Abstract: This work should not be considered as the ultimate word about individual theological views, but rather as part of an ongoing conversation that will hopefully lead to wider consideration and exploration of these issues as xenotransplantation science advances towards clinical trials.

Cited by 60 publications

References 26 publications

Student nurses at Spanish universities and their attitude toward xenotransplantation

Student nurses at Spanish universities and their attitude toward xenotransplantation

Ethical rejections of xenotransplantation?

The importance of public engagement in clinical xenotransplantation

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