Jet lag syndrome: circadian organization, pathophysiology, and management strategies

Vosko, Andrew M.; Colwell, Christopher S.; Avidan, Alon Y.

doi:10.2147/nss.s6683

Cited by 31 publications

(8 citation statements)

References 86 publications

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“…An individual may be able to choose to change their sleep/meal/activity time due to day-to-day schedule impositions, but they may not be able to shift their internal clocks in the same way, due to its genetic basis. This limit in flexibility is presumed to underlie the many ailments associated with jet lag ( e.g ., see 6 , 7 ).…”

Section: Introductionmentioning

confidence: 98%

3.4 million real-world learning management system logins reveal the majority of students experience social jet lag correlated with decreased performance

Smarr

Schirmer

2018

Sci Rep

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Misalignments between endogenous circadian rhythms and the built environment (i.e., social jet lag, SJL) result in learning and attention deficits. Currently, there is no way to assess the impact of SJL on learning outcomes of large populations as a response to schedule choices, let alone to assess which individuals are most negatively impacted by these choices. We analyzed two years of learning management system login events for 14,894 Northeastern Illinois University (NEIU) students to investigate the capacity of such systems as tools for mapping the impact of SJL over large populations while maintaining the ability to generate insights about individuals. Personal daily activity profiles were validated against known biological timing effects, and revealed a majority of students experience more than 30 minutes of SJL on average, with greater amplitude correlating strongly with a significant decrease in academic performance, especially in people with later apparent chronotypes. Our findings demonstrate that online records can be used to map individual- and population-level SJL, allow deep mining for patterns across demographics, and could guide schedule choices in an effort to minimize SJL’s negative impact on learning outcomes.

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Section: Introductionmentioning

confidence: 98%

3.4 million real-world learning management system logins reveal the majority of students experience social jet lag correlated with decreased performance

Smarr

Schirmer

2018

Sci Rep

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“…Neuronal activities in the SCN modulate entrainment through multiple neuro-hormonal pathways to other brain structures and peripheral oscillators in the other organs including heart and liver. 10 Through these mechanisms, entrainment optimises health by ensuring that the internal rhythms of metabolism and cardiovascular physiology are synchronised to daily variations in the light/dark cycle and other recurrent environmental challenges. 11 Erratic cycles in the light/dark cycle, food availability or social interaction can affect the alignment between endogenous clocks and the environment, a condition associated with detrimental effects on metabolic and mental health.…”

Section: Introductionmentioning

confidence: 99%

Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats

Noor

Wyse

Roy

et al. 2016

J Cereb Blood Flow Metab

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Photoperiod disruption, which occurs during shift work, is associated with changes in metabolism or physiology (e.g. hypertension and hyperglycaemia) that have the potential to adversely affect stroke outcome. We sought to investigate if photoperiod disruption affects vulnerability to stroke by determining the impact of photoperiod disruption on infarct size following permanent middle cerebral artery occlusion. Adult male Wistar rats (210–290 g) were housed singly under two different light/dark cycle conditions (n = 12 each). Controls were maintained on a standard 12:12 light/dark cycle for nine weeks. For rats exposed to photoperiod disruption, every three days for nine weeks, the lights were switched on 6 h earlier than in the previous photoperiod. T2-weighted magnetic resonance imaging was performed at 48 h after middle cerebral artery occlusion. Disruption of photoperiod in young healthy rats for nine weeks did not alter key physiological variables that can impact on ischaemic damage, e.g. blood pressure and blood glucose immediately prior to middle cerebral artery occlusion. There was no effect of photoperiod disruption on infarct size after middle cerebral artery occlusion. We conclude that any potentially adverse effect of photoperiod disruption on stroke outcome may require additional factors such as high fat/high sugar diet or pre-existing co-morbidities.

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“…The final component of the eligibility criteria is related to the primary objective of the cohort study, which was to study the effects of working in underground spaces on sleep quality and melatonin levels. Frequent travel across different time zones could potentially influence these outcomes due to circadian disruption [13]. Participants were recruited between 16 August 2016 and 13 January 2017.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore

Sathish

Dunleavy

Soljak

et al. 2019

IJERPH

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We aimed to examine the behavioural and clinical risk factors for non-communicable diseases (NCDs) at baseline and their changes over 12 months in a workplace cohort in Singapore. A total of 464 full-time employees (age ≥ 21 years) were recruited from a variety of occupational settings, including offices, control rooms, and workshops. Of these, 424 (91.4%) were followed-up at three months and 334 (72.0%) were followed up at 12 months. Standardized questionnaires were used to collect data on health behaviours and clinical measurements were performed by trained staff using standard instruments and protocols. Age-adjusted changes in risk factors over time were examined using generalized estimating equations or linear mixed-effects models where appropriate. The mean age of the participants at baseline was 39.0 (SD: 11.4) years and 79.5% were men. Nearly a quarter (24.4%) were current smokers, slightly more than half (53.5%) were alcohol drinkers, two-thirds (66%) were consuming <5 servings of fruit and vegetables per day, and 23.1% were physically inactive. More than two-thirds (67%) were overweight or obese and 34.5% had central obesity. The mean follow-up was 8.6 months. After adjusting for age, over 12 months, there was a significant increase in the proportion consuming <5 servings of fruit and vegetables per day by 33% (p = 0.030), who were physically inactive by 64% (p < 0.001), and of overweight or obese people by 15% (p = 0.018). The burden of several key NCD risk factors at baseline was high and some worsened within a short period of time in this working population. There is a need for more targeted strategies for behaviour change towards a healthy lifestyle as part of the ongoing health and wellness programs at workplaces in Singapore.

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Jet lag syndrome: circadian organization, pathophysiology, and management strategies

Cited by 31 publications

References 86 publications

3.4 million real-world learning management system logins reveal the majority of students experience social jet lag correlated with decreased performance

3.4 million real-world learning management system logins reveal the majority of students experience social jet lag correlated with decreased performance

Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats

Risk Factors for Non-Communicable Diseases at Baseline and Their Short-Term Changes in a Workplace Cohort in Singapore

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