Jet-induced skin puncture and its impact on needle-free jet injections: Experimental studies and a predictive model

Baxter, Joy; Mitragotri, Samir

doi:10.1016/j.jconrel.2005.05.023

Cited by 125 publications

(86 citation statements)

References 27 publications

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“…However, such a backflow model would experimentally be evidenced by an asymptotic depth of injection resulting from an insufficient kinetic energy of the jet to induce further material failure [36]. As we do not observe this asymptotic depth of injection in Fig.…”

Section: Depth-controlled Injection For Direct Three-dimensional Liqumentioning

confidence: 73%

“…A possible backflow of the injected liquid towards the substrate surface could also account for both the low dispersion of injection and the presence of the larger volume of liquid on the substrate surface, respectively, because backflow could reduce the ability of the microjet to induce further cracks in the gelatin and because liquid could flow back towards the gelatin's surface [36]. However, such a backflow model would experimentally be evidenced by an asymptotic depth of injection resulting from an insufficient kinetic energy of the jet to induce further material failure [36].…”

Section: Depth-controlled Injection For Direct Three-dimensional Liqumentioning

confidence: 99%

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Depth-controlled laser-induced jet injection for direct three-dimensional liquid delivery

et al. 2018

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Needle-free jet injection enables the delivery of drugs into skin or soft tissue by puncturing them with a high-velocity liquid jet. However, precise and efficient drug delivery requires generating such liquid jets with both a controlled velocity and a high throughput, which remains challenging with current spring-and gas-actuated jet injectors. Here, we propose a depth-controlled and high-throughput injection method by adapting laser-induced forward transfer (LIFT), a high-resolution two-dimensional printing technique, for direct three-dimensional liquid delivery into soft tissues.The velocity of thin liquid jets is laser actuated from 10 to 85 m/s so that doses as small as 10 pL, not achievable with other injectors, are injected at a 1 Hz repetition rate into a 300 μm thick soft gelatin substrate with a 25 μm depth precision and 12 μm lateral resolution. We further investigate the potential of this liquid delivery technique as a direct three-dimensional cell-delivery vehicle and show that depth-controlled particle delivery requires high-delivery efficiency. Our direct three-dimensional liquid delivery system opens up more possibilities for pinpoint drug delivery in soft tissues or tissue-engineered constructs.

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Section: Depth-controlled Injection For Direct Three-dimensional Liqumentioning

confidence: 73%

Section: Depth-controlled Injection For Direct Three-dimensional Liqumentioning

confidence: 99%

Depth-controlled laser-induced jet injection for direct three-dimensional liquid delivery

et al. 2018

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“…Most jet injectors eject volumes of 10 to 500 µl. However, the injection depth has been shown to be correlated to the injection volume (Baxter & Mitragotri 2005). Therefore, for superficial injection the injected volume should be reduced, resulting in a microjet, which is designed to inject volumes in the nanolitre range (Arora et al 2007;Stachowiak et al 2007;Jang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the injected volume, it has been reported that jet velocity, nozzle diameter, and stiffness of the penetrated material influence the penetration depth (Schramm- Baxter & Mitragotri 2005). Contrary, there is a paucity of data on the penetration process and efficiency of microjet injectors.…”

Section: Introductionmentioning

confidence: 99%

Penetration and delivery characteristics of repetitive microjet injection into the skin

Römgens

Rem-Bronneberg

Kassies

et al. 2016

Journal of Controlled Release

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“…Shergold-Fleck model gives the penetration pressure but no explicit information on the penetration depth. The depth of penetration achieved by high speed liquid jet injections has been measured by Baxter and Mitragotri [2005]: The depth of penetration into dermis and subcutaneous adipose tissue was a function of both the diameter and velocity of the jet.…”

Section: Introductionmentioning

confidence: 99%

Deep penetration and liquid injection into adipose tissue

Comley

Fleck

2011

J. Mech. Mater. Struct.

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The subcutaneous injection of porcine adipose tissue by a hypodermic needle involves two stages: tissue penetration followed by the delivery of liquid into the tissue. The force required to penetrate adipose tissue by a series of conically tipped and flat-bottomed circular punches has been measured. Scanning electron microscopy and light microscopy are used to observe the mechanism of crack formation during penetration. The experiments reveal that penetration by either a flat bottomed or 45• conically tipped punch involves the formation of a mode II ring crack. The predicted penetration pressure according to the Shergold-Fleck model (Proc. R. Soc. Lond. A 460 (2004), 3037-3058) is in good agreement with the measured pressure on the punch. The subsequent delivery of liquid into adipose tissue by the hypodermic needle has also been examined: the injection pressure for phosphate buffered saline has been measured for a range of flow rates. X-ray images of the injected liquid suggest that micro-cracks are formed by the fluid pressure within the tissue and this leads to an increase in permeability. A seepage model is developed, based on the Darcy flow law, to relate the volumetric flow rate to the injection delivery pressure. Finally, a model of hydraulic fracture is used to assess the toughness associated with the formation of the micro-cracks during injection.

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Jet-induced skin puncture and its impact on needle-free jet injections: Experimental studies and a predictive model

Cited by 125 publications

References 27 publications

Depth-controlled laser-induced jet injection for direct three-dimensional liquid delivery

Depth-controlled laser-induced jet injection for direct three-dimensional liquid delivery

Penetration and delivery characteristics of repetitive microjet injection into the skin

Deep penetration and liquid injection into adipose tissue

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