Jejunal tissue oxygenation and microvascular flow motion during hemorrhage and resuscitation

Abstract

tissue oxygenation and microvascular flow motion during hemorrhage and resuscitation.

Hemodynamic Parameters Change Earlier Than Tissue Oxygen Tension in Hemorrhage

“…Cardiac index, PAOP, and tissue oxygen tension of the jejunum after hemorrhage in a recent study in pigs [17] reacted comparably to our study. However, MAP did not decrease significantly after 15% of blood loss in Pajk's study [17], while MAP decreased significantly after 10% of blood loss in our study.…”

“…However, MAP did not decrease significantly after 15% of blood loss in Pajk's study [17], while MAP decreased significantly after 10% of blood loss in our study. Probably the different anesthesia technique (total intravenous anesthesia in Pajk's study versus isoflurane anesthesia in our study) contributed to this difference.…”

“…Probably the different anesthesia technique (total intravenous anesthesia in Pajk's study versus isoflurane anesthesia in our study) contributed to this difference. Another reason for the different results could be the use of dopamine (16 mcg/mL/min) in Pajk's study [17]. Dopamine vasoconstricts metarterioles due to its a-adrenergic effects.…”

“…This may have led to unchanged MAP values in spite of 15% of blood loss in Pajk's study. Finally, Pajk used LRS and gelatin as maintenance fluids [17], while we used LRS only. Gelatin is a colloid; its oncotic pressure is higher than the oncotic pressure in plasma.…”

Receptor-Mediated Events in the Microcirculation

“…Several studies have demonstrated that infusion of dopamine (or its agonists) during hemorrhage or following resuscitation improves tissue oxygenation in the splanchnic circulation [141,142] . Dopamine also prevents rhythmic oscillations in blood flow during hemorrhage that apparently contributes to reduced oxygenation [142] .…”