Jejunal Intussusception Associated with Lymphoma in a Horse

Matsuda, Kazuo; Shimada, Tatsuya; Kawamura, Yoshio; Sakaguchi, Kanako; Tagami, Masaaki; Taniyama, Hiroyuki

doi:10.1292/jvms.13-0060

Cited by 11 publications

(11 citation statements)

References 18 publications

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“…In this report a retrograde intussusception of the descending colon was discovered during surgery. Intussusceptions may be caused by abnormal motility patterns secondary to intestinal neoplasms (Boulton and Williamson 1984;Matsuda et al 2013), previous resection and anastomosis (Frankeny et al 1995), parasitism, enteritis, Retrograde intussusception in a neonatal foal intraluminal masses, mesenteric arteritis, and sudden dietary changes (Edwards 1986;Greet 1992). In this case, we speculated that the retrograde intussusception was caused by the hamartomas and associated connecting fibrous band.…”

Section: Discussionmentioning

confidence: 83%

Retrograde intussusception of the descending colon secondary to multiple colonic hamartomas in a neonatal foal

Mejía

Hurcombe

Rodgerson

et al. 2019

Equine Veterinary Education

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A neonatal Thoroughbred filly presented with a 3-h history of abdominal pain and distention that failed to respond to medical treatment. Diagnostic evaluation, including abdominal ultrasound, barium enema and proctoscopy, was suggestive of atresia coli. Exploratory laparotomy revealed a pedunculated mass in the wall of the diaphragmatic flexure of the ascending colon. The mass, subsequently diagnosed as a hamartoma, was attached to a smaller hamartoma by a fibrous pedicle originating from the descending colon. The descending colon had intussuscepted retrograde into the ascending colon along the fibrous band. The filly was euthanised due to poor prognosis.

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Section: Discussionmentioning

confidence: 83%

Retrograde intussusception of the descending colon secondary to multiple colonic hamartomas in a neonatal foal

Mejía

Hurcombe

Rodgerson

et al. 2019

Equine Veterinary Education

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“…; Matsuda et al . ), likely due to the local inflammation caused by the tumour and mass lesions affecting gastrointestinal motility, predisposing to entrapment, intussusception and volvulus. In five cases the tumour was found at surgery as an incidental finding and removed.…”

Section: Discussionmentioning

confidence: 99%

Intestinal neoplasia: A review of 34 cases

Spanton¹,

Smith²,

Sherlock

et al. 2018

Equine Veterinary Education

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Summary The clinicopathological features of 34 horses with a histological diagnosis of intestinal neoplasia were reviewed; these included 17 horses with lymphoma, five with gastrointestinal stromal tumours (GISTs), four with adenocarcinomas, three with leiomyosarcomas, two with leiomyomas, two with squamous cell carcinomas (SCC) and one with adenocarcinoma/mesothelioma. The mean age at presentation was 19 years (range 3–36 years), and 81% of cases occurred in horses aged 15 years or older. Weight loss, acute or recurrent colic, inappetence, diarrhoea, depression and pyrexia were the most common presenting clinical signs. Hyperfibrinogenaemia, hypoalbuminaemia and leukocytosis were the most common clinical pathological findings. Transabdominal ultrasonography and exploratory laparotomy were the most useful diagnostic tests. Neoplasia was identified in all regions of the intestinal tract, with the jejunum being most frequently affected. The presence of mass lesions or thickened intestinal walls on transabdominal ultrasound, coupled with other clinical findings, were suggestive of intestinal neoplasia. Where possible, complete surgical resection offered the best prognosis, but generally the prognosis was poor to hopeless.

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“…Das Alter der Tiere lag zwischen 2 und 21 Jahren, im Median 17 Jahre. Es konnte bestätigt werden, dass die häufigste Lokalisation der intestinalen Form der Dünndarm ist (Matsuda et al 2013, Pinkerton et al 2002, Taylor et al 2006 Roy et al 2002, Wright und Edwards 1984. In der vorliegenden Studie ließ sich keine klare Dominanz hinsichtlich der Verteilung erkennen, da in drei Fällen der Dickdarm und in zwei Fällen der Dünndarm betroffen waren.…”

Section: Diskussionunclassified

Intestinal tumors and tumor-like lesions in horses

Kempker¹,

Potocnik²,

Schliewert³

et al. 2018

PHK

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Zusammenfassung: Diese Studie gibt einen Überblick über 25 intra operationem entnommene und histologisch, sowie immunhistologisch aufgearbeitete Umfangsvermehrungen des Pferdedarms. Es wurden Proben von 25 Pferden mit einem Alter von 2 -25 Jahren mit anatomischer Assoziation zum Dünn-oder Dickdarm in die Studie einbezogen. Knapp die Hälfte der Tiere waren weiblich. Der Großteil der Patienten waren Warmblüter, weiterhin zwei Ponys, Andalusier, zwei Kaltblüter sowie ein Quarter Horse und ein Gangpferd. Die Proben wurden in Formalin fixiert und gemäß den Standardanweisungen aufgearbeitet. Die histologische Diagnose und immunhistologischen Befunde wurden im klinischen Kontext bewertet. Klinisch und makroskopisch konnte keine Vorhersage hinsichtlich der Art und Dignität der Umfangsvermehrungen getroffen werden. Die klinischen Symptome in Form von Kolik, Anorexie, Durchfall oder Fieber waren unspezifisch. In zwei Fällen handelte es sich um nicht neoplastische Veränderungen (Hämatom und chronisches Granulationsgewebe). Bei den Tumoren machten die Spindelzelltumoren den größten Anteil aus (vier Leiomyome, drei Leiomyosarkome, ein GIST). Die zweitgrößte Gruppe stellten die Lymphome (7/25) dar. Fünf Umfangsvermehrungen wurden als Adenokarzinome klassifiziert, wovon drei eine knöchernde Metaplasie aufwiesen. Weiterhin fanden sich drei noduläre Gefäßproliferate. Eine Rassen-oder Geschlechtsdisposition konnte nicht festgestellt werden. Alle Pferde, zu denen Angaben vorlagen, wurden bereits intra operationem euthanasiert. Da die klinischen Symptome sehr variabel sind, sich aber je nach Zellursprung bzw. Dignität bedeutende Unterschiede hinsichtlich der Prognose ergeben können, ist eine chirurgische Exstirpation und anschließende histopathologische Untersuchung anzuraten. Weiterhin sollte insbesondere bei Abmagerung und rezidivierende Koliken an eine Umfangsvermehrung des Darms als Ursache gedacht werden, die aber nicht immer maligne ist. Schlüsselwörter: GIST, intestinales Lymphom, Adenokarzinom, Sarkom, knöchernde Metaplasie Intestinal tumors and tumor-like lesions in horsesIntestinal neoplasia is rare in horses. Lymphoma is the most common form, other intestinal neoplasms include adenocarcinoma, leiomyoma, leiomyosarcoma or gastrointestinal stromal tumors (GIST). Clinical signs are non-specific and include weight loss, colic or diarrhea. The aim of this study was to evaluate tissue samples from 25 horses with intestinal masses. We collected tissue material from 25 horses with masses in the small or large intestine between 2011 and 2017. Included were only samples directly connected to the intestine which were submitted for routine diagnostics. Clinical history was included. Tissue samples were formalin-fixed and embedded using standard methods. Histology and immunohistology (Vimentin, SMA, Desmin, S100, c-Kit, CD20, CD3, FVIII, CD31, cytokeratin) were performed. In 20 cases the clinical history was known. The horses' age ranged from 2-22 years (median 13 years). Patients showed poor body condition, weight loss or cachexia (2...

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Jejunal Intussusception Associated with Lymphoma in a Horse

Cited by 11 publications

References 18 publications

Retrograde intussusception of the descending colon secondary to multiple colonic hamartomas in a neonatal foal

Retrograde intussusception of the descending colon secondary to multiple colonic hamartomas in a neonatal foal

Intestinal neoplasia: A review of 34 cases

Intestinal tumors and tumor-like lesions in horses

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