Jejunal Gastrointestinal Stromal Tumor: A Diagnostic Challenge

Abstract

Gastrointestinal stromal tumors (GISTs) are a common type of soft tissue sarcoma that originates from the interstitial cells of Cajal in the gastrointestinal (GI) tract. These tumors usually affect people above 50 years of age and can be difficult to diagnose, as symptoms can be vague and nonspecific, with some patients remaining asymptomatic. Early diagnosis and treatment are crucial because GISTs can be aggressive and may metastasize.We present a case of a 74-year-old man who presented to our hospital with GI bleeding and anemia. Despite initial investigations, the source of bleeding was not identified until capsule endoscopy and then balloon enteroscopy revealed an ulcerated mass in the jejunum. The tumor was successfully removed using a minimally invasive laparoscopic approach, and the histopathologic report confirmed the diagnosis of GIST. The patient had an uneventful postoperative course. This case highlights the importance of considering GISTs in the differential diagnosis of obscure GI bleeding. A multidisciplinary approach is essential to ensure the best outcomes for these patients. Additionally, the use of minimally invasive surgery should be considered whenever possible to minimize postoperative complications and promote faster recovery.

Exploring Perforated Jejunal GIST: A Rare Case Report and Review of Molecular and Clinical Literature

“…Jejunal GISTs are unique in their clinical presentation and prognosis due to their rarity and tendency for severe complications. While GISTs are relatively uncommon mesenchymal neoplasms of the gastrointestinal tract, those originating in the jejunum are especially rare [74]. Perforation in jejunal GISTs is an infrequent but serious complication, leading to acute diffuse peritonitis [12].…”

Gastrointestinal Stromal Tumor (GIST): About 3 Cases

“…Tumors in the small and large bowel typically require bowel anastomosis after resection, which can be performed using intracorporal or extracorporeal suturing or stapling. [5,6,9,12].…”

“…Commonly used TKIs include imatinib and sunitinib, which are administered as long as the tumor does not grow [4,5,9].…”

“…The goal is to prevent or treat symptoms, side effects, and psychological, social, and spiritual problems, thereby improving the quality of life for patients. Radiation therapy may be used for pain management as part of supportive care [5,7,9].…”