We have proposed a general numerical framework for plasma simulations on GPU (Graphics Processing Units) clusters based on the microscopic kinetic equations with full collision terms. Our numerical algorithm consistently deals with both the long-range (classical forces in the Vlasov term) and the short-range (quantum processes in the collision term) interactions. Providing the relevant particle masses, charges, and types (classical, fermionic or bosonic), as well as the external forces and the matrix elements (in the collisional integral), the algorithm consistently solves the coupled multi-particle kinetic equations. Currently, the framework is tested and applied in the field of relativistic heavy-ion collisions; extensions to other plasma systems are straight forward. Our framework is a potential and competitive numerical platform for consistent plasma simulations.