Jeannette Wilkins Award: Can Locally Delivered Gadolinium Be Visualized on MRI? A Pilot Study

Giers, Morgan B.; Estes, Chris S.; McLaren, A. C.; Caplan, Michael R.; McLemore, Ryan

doi:10.1007/s11999-012-2315-6

Cited by 6 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We studied the distribution of Gd-DTPA as an antimicrobial surrogate from Gd-DTPA-loaded bone cement (GLBC) as previously described [13,14]. Standardized GLBC implants made with three Gd-DTPA loads were implanted in a rabbit wound model and imaged at 7, 14, and 33 days.…”

Section: Methodsmentioning

confidence: 99%

“…However, tissue biopsies inherently do not provide continuous spatial and temporal distributions. Our laboratory has previously reported on gadolinium-labeled diethylenetriamine pentaacetic acid (Gd-DTPA) as an antimicrobial surrogate and the ability of 7-T MRI to quantify the distribution of Gd-DTPA over a period of 5 hours after local delivery throughout surgical wounds [13,14]. Although Gd-DTPA is not intracellularly transported [14] and does not bind protein as some antimicrobials do at systemic concentrations, it does have similar molecular weight, solubility, and diffusivity and will be locally transported very similarly to many water-soluble antimicrobials [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Distribution From Local Delivery Depends on Dose

McLaren

Giers

Fraser

et al. 2014

Clinical Orthopaedics &Amp; Related Research

Self Cite

View full text Add to dashboard Cite

Background Tissue distribution after local delivery has been quantified over a period of 5 hours on 7-T MRI in a rabbit model using gadolinium-labeled diethylenetriamine pentaacetic acid (Gd-DTPA) as an antimicrobial surrogate; however, it is unknown how the Gd-DTPA load in a local depot will affect the duration of high-concentration Gd-DTPA in local tissues after surgical débridement. Questions/purposes We determined whether the Gd-DTPA load in bone cement affected its local tissue distribution over a period of 1 month after local delivery.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Distribution From Local Delivery Depends on Dose

McLaren

Giers

Fraser

et al. 2014

Clinical Orthopaedics &Amp; Related Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Gadolinium based contrast agents have been used as mock drugs to study the distribution of drug away from implant systems in targeted tissues such as the eye [58, 59], brain [60], bone [61–63] and muscle [63, 64]. In one study by Csaky et al , the mass transport and distribution of an ocular drug released from a polyvinyl alcohol (PVA) polymeric implant was investigated by using its surrogate, Gd-DTPA (Fig.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…2) [58]. In another study with Gd-DTPA, which is similar in size and diffusion coefficient to the antimicrobials gentamicin and vancomycin, was also used to visualize drug transport from orthopedic implants [65]. In this study, implants of different materials were implanted in either the intramedullary canal or the quadriceps and the local drug distubtions away from the implants were assessed using MRI.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

See 1 more Smart Citation

Biomedical Imaging in Implantable Drug Delivery Systems

Zhou¹,

Hernandez²,

Goss³

et al. 2015

CDT

View full text Add to dashboard Cite

Implantable drug delivery systems (DDS) provide a platform for sustained release of therapeutic agents over a period of weeks to months and sometimes years. Such strategies are typically used clinically to increase patient compliance by replacing frequent administration of drugs such as contraceptives and hormones to maintain plasma concentration within the therapeutic window. Implantable or injectable systems have also been investigated as a means of local drug administration which favors high drug concentration at a site of interest, such as a tumor, while reducing systemic drug exposure to minimize unwanted side effects. Significant advances in the field of local DDS have led to increasingly sophisticated technology with new challenges including quantification of local and systemic pharmacokinetics and implant-body interactions. Because many of these sought-after parameters are highly dependent on the tissue properties at the implantation site, and rarely represented adequately with in vitro models, new nondestructive techniques that can be used to study implants in situ are highly desirable. Versatile imaging tools can meet this need and provide quantitative data on morphological and functional aspects of implantable systems. The focus of this review article is an overview of current biomedical imaging techniques, including magnetic resonance imaging (MRI), ultrasound imaging, optical imaging, X-ray and computed tomography (CT), and their application in evaluation of implantable DDS.

show abstract

Distribution of molecules locally delivered from bone cement

et al. 2013

Self Cite

View full text Add to dashboard Cite

Revision of infected orthopedic implants is successful in most cases when antimicrobials are delivered locally (mixed with bone cement or bone graft which is placed in the site from which the infected tissue was removed); however, there is still a substantial rate of recurrence most likely due to the antimicrobials not achieving a therapeutic dose at all locations in the tissue. To study transport within this environment, gadolinium chelated in diethylene triamine pentaacetic acid (Gd-DTPA), a MRI contrast agent with size and solubility similar to two common antimicrobials (gentamicin and vancomycin), was mixed with bone cement, implanted in vivo into two models of orthopedic surgical wounds, and imaged using MRI 5.5 h after implantation. Image thresholding was used to create two-dimensional and three-dimensional representations of areas/volumes containing detectable concentrations of Gd-DTPA. Distribution is found to be anisotropic with Gd-DTPA transporting preferentially anterior of the implant toward the skin. When fascia is not closed over the implant site, Gd-DTPA transports to the skin and along the subcutaneous plane. The distance transported indicates that transport is likely driven by convection. Finally, the tissue concentration of Gd-DTPA is much less than the concentration loaded into the bone cement.

show abstract

Jeannette Wilkins Award: Can Locally Delivered Gadolinium Be Visualized on MRI? A Pilot Study

Cited by 6 publications

References 21 publications

Antimicrobial Distribution From Local Delivery Depends on Dose

Antimicrobial Distribution From Local Delivery Depends on Dose

Biomedical Imaging in Implantable Drug Delivery Systems

Distribution of molecules locally delivered from bone cement

Contact Info

Product

Resources

About