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Cost-effectiveness Analysis of Genotype-Specific Surveillance and Preventive Strategies for Gynecologic Cancers Among Women With Lynch Syndrome

“…Gene-specific and age-specific probabilities of developing EC or OC were derived from published literature ( Table 2 ; eTable 1 in the Supplement ). 3 , 9 , 13 , 14 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 Until age 75 years, EC risks range from 11.8% to 48.9% and OC risks from 3.0% to 17.4%. 3 We assumed that EC and OC diagnoses were independent events and that after 1 cancer diagnosis was made, a patient was no longer at risk of developing the other cancer.…”