2004
DOI: 10.1038/sj.onc.1207728
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JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumors

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Cited by 44 publications
(49 citation statements)
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“…In general, T-Ag of JCV is found predominantly in the nucleus; however, we were able to detect a pool of T-Ag at the cell surface that colocalized with b-catenin. This is in accord with other observations where JCV T-Ag was reported to interact with a variety of membrane-associated proteins such as NF2 or IRS-1 (Shollar et al, 2004). Accordingly, a close relative of JCV T-Ag, the SV40 T-Ag was also demonstrated to associate with the membrane (Butel et al, 1989).…”
Section: Discussionsupporting
confidence: 81%
“…In general, T-Ag of JCV is found predominantly in the nucleus; however, we were able to detect a pool of T-Ag at the cell surface that colocalized with b-catenin. This is in accord with other observations where JCV T-Ag was reported to interact with a variety of membrane-associated proteins such as NF2 or IRS-1 (Shollar et al, 2004). Accordingly, a close relative of JCV T-Ag, the SV40 T-Ag was also demonstrated to associate with the membrane (Butel et al, 1989).…”
Section: Discussionsupporting
confidence: 81%
“…5,[9][10][11]30,33,49,54,59 Glioblastoma and other astrocytic, glial-derived primary brain tumors have been reproduced experimentally in laboratory rodents (Sprague Dawley rats) and nonhuman primates (new world owl and squirrel monkeys) after intracranial inoculation of JCV. In these studies, large T antigen was demonstrated in neoplastic cells, and the JCV genome was integrated into the cellular DNA, indicating a clonal origin for the tumors.…”
Section: Discussionmentioning
confidence: 99%
“…These bonds promote the impairment of the homology-directed DNA repair mechanism, 38 the enhancement of c-myc and cyclin D1 gene expression, 34,35 the lack of positive regulation of p53 36 and the significant decrement of the apoptotic process. BKV T Ag activates the DNA methyltransferase 1 gene 39 that is associated with tumorigenesis through tumor suppressor gene hypermethylation (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, other cellular proteins, such as insulin receptor substrate 1 (IRS-1), 33 β-catenin, 34,35 the neurofibromatosis type 2 gene product 36 and the anti-apoptotic protein survivin, 37 are implicated in binding to JCV T Ag. These bonds promote the impairment of the homology-directed DNA repair mechanism, 38 the enhancement of c-myc and cyclin D1 gene expression, 34,35 the lack of positive regulation of p53 36 and the significant decrement of the apoptotic process.…”
Section: Introductionmentioning
confidence: 99%