JCS/JSCS/JATS/JSVS 2020 Guidelines on the Management of Valvular Heart Disease

Izumi, Chisato; Eishi, Kiyoyuki; Ashihara, Kaoru; Arita, Tomohiro; Otsuji, Yutaka; Kunihara, Takashi; Komiya, Tatsuhiko; Shibata, Toshihiko; Seo, Yoshihiro; Daimon, Masao; Takanashi, Shuichiro; Tanaka, Hiroyuki; Nakatani, Satoshi; Ninami, Hiroshi; Nishi, Hiroyuki; Hayashida, Kentaro; Yaku, Hitoshi; Yamaguchi, Junichi; Yamamoto, Kazuhide; Watanabe, Hiroyuki; Abe, Yukio; Amaki, Makoto; Amano, Masashi; Obase, Kikuko; Tabata, Minoru; Miura, Takashi; Miyake, Makoto; Murata, Mitsushige; Watanabe, Nozomi; Akasaka, Takashi; Okita, Yutaka; Kimura, Takeshi; Sawa, Yoshiki; Yoshida, Kiyoshi

doi:10.1253/circj.cj-20-0135

Cited by 166 publications

(129 citation statements)

References 499 publications

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“…In human medicine, the classification of mitral regurgitation (MR) is based on the Carpentier Classification, which divides MR into three types based on leaflet motion [ 29 , 35 ]. For assessing the severity, echocardiography is used to examine items, such as the proximal flow convergence, jet area or jet area/left atrial area ratio, and mitral inflow velocity [ 15 , 29 , 35 ]. In human MR, cardiac murmurs are known as holosystolic murmurs, and in serious cases, Carey Coombs murmurs have been found [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Pai

Nakayama

Ito-Fujishiro

et al. 2021

The Journal of Veterinary Medical Science

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Nonhuman primates are commonly used as experimental animals due to their biological resemblance to humans. In patients with cardiac disease, the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) tend to increase in response to cardiac damage, and they are thus used as indicators for the diagnosis of human heart failure. However, no reference values for ANP and BNP have been reported for heart disease in nonhuman primates. In this study, we recorded the age, sex, and body weight of 202 cynomolgus monkeys, and performed evaluations to assess the ANP and BNP levels, electrocardiography and echocardiography, and accordingly divided the monkeys into two groups: healthy monkeys and those with spontaneous cardiac disease. Statistical analysis was performed to determine the relationship of ANP and BNP with the factors of age, sex, and body weight. No significant relationship was found between the levels of ANP and BNP and the factors of age, sex, and body weight. However, both the ANP and BNP levels were significantly different between the healthy monkeys and monkeys with valvular disease. Similar to humans, the ANP and BNP levels tended to increase with the progression of cardiac disease in monkeys. Based on these results, we concluded that ANP and BNP are indicators of cardiac disease in nonhuman primates, and that this nonhuman primate cardiac disease model is applicable for cardiology research in humans.

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Section: Methodsmentioning

confidence: 99%

Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Pai

Nakayama

Ito-Fujishiro

et al. 2021

The Journal of Veterinary Medical Science

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“…Progression of aneurysmal diameter is significantly faster with BAV than with TAV, even after aortic valve replacement 5,6 , possibly due to underlying intrinsic medial fragility combined with long-term exposure to BAV-related hemodynamic alterations. Therefore, the current guidelines on aortic diseases generally recommend early surgical intervention in a significantly dilated ascending aorta with BAV-defined as maximum diameter > 45 mm-to prevent sudden death from aortic dissection or rupture [7][8][9] . However, the treatment of a mildly dilated ascending aorta (40-45 mm) at the time of aortic valve surgery remains controversial due to the markedly heterogeneous characteristics of aortopathy in BAV 10,11 .With the recent improvements in pre-procedural imaging and devices, transcatheter aortic valve implantation (TAVI) is considered a safe and feasible treatment option for aortic valve stenosis with BAV 12 .…”

mentioning

confidence: 99%

Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system

Hattori

Nakama

Takada

et al. 2021

Sci Rep

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The characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance imaging-compatible pulsatile flow circulation system was developed to quantify the outflow jet. The eccentricity and circulation values of the peak systolic jet were compared among tricuspid aortic valve (TAV), three asymmetric BAVs, and two symmetric BAVs. The results showed mean aortic flow and leakage did not differ among the five BAVs (six samples, each). Asymmetric BAVs demonstrated the eccentric outflow jets directed to the aortic wall facing the smaller leaflets. In the asymmetric BAV with the smaller leaflet facing the right-anterior, left-posterior, and left-anterior quadrants of the aorta, the outflow jets exclusively impinged on the outer curvature of the ascending aorta, proximal arch, and the supra-valvular aortic wall, respectively. Symmetric BAVs demonstrated mildly eccentric outflow jets that did not impinge on the aortic wall. The circulation values at peak systole increased in asymmetric BAVs. The bicuspid symmetry and the position of smaller leaflet were determinant factors of the characteristics of aortic valvular outflow jet.

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“…The American College of Cardiology (ACC)/American Heart Association (AHA) guideline for the managements of valvular heart diseases 1 was revised in December 2020. Ahead of the ACC/AHA guideline, we published the revision of the Japanese Circulation Society (JCS) guideline 2 in March 2020 (English version, in September). Guidelines are formulated based on the evidence from previous studies, but also reflecting actual current clinical practice of each country.…”

Section: Chisato Izumimentioning

confidence: 99%

JCS/JSCS/JATS/JSVS 2020 Guidelines on the Management of Valvular Heart Disease

Cited by 166 publications

References 499 publications

Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system

Perspectives of managements of valvular heart diseases in transcatheter intervention era: What should we discuss from the guidelines?

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