JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure

Tsutsui, Hiroyuki; Ide, Tomomi; Ito, Hiroshi; Kihara, Yasuki; Kinugawa, Koichiro; Kinugawa, Shintaro; Makaya, Miyuki; Murohara, Toyoaki; Node, Koichi; Saito, Yoshihiko; Sakata, Yasushi; Shimizu, Wataru; Yamamoto, Kazuhide; Bando, Yasuko K; Iwasaki, Yu‐ki; Kinugasa, Yoshiharu; Mizote, Isamu; Nakagawa, Hitoshi; Oishi, Shogo; Okada, Akiko; Tanaka, Atsushi; Akasaka, Takashi; Ōno, Minoru; Kimura, Takeshi; Kosaka, Shun; Kosuge, Masami; Momomura, Shin‐ichi

doi:10.1253/circj.cj-21-0431

Cited by 98 publications

(82 citation statements)

References 242 publications

(141 reference statements)

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“…The prevalence of heart failure is increasing, and optimal physical and medical prophylactic and therapeutic strategies are still to be determined. 1 – 3 Of note, the management of pulmonary congestion is important to improve mortality and morbidity, as well as patients’ quality of life. 4 In addition to appropriate diuretic therapy, appropriate body posture helps prevent worsening heart failure.…”

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confidence: 99%

Relationship Between Body Posture and Lung Fluid Volume Assessed Using a Novel Noninvasive Remote Dielectric Sensing System

et al. 2022

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demonstrated a correlation between ReDS values and lung fluid levels, 8,9 as well as the clinical implications of ReDSguided heart failure management. 10, 11 The Second Department of Internal Medicine, Toyama University received permission to use the device for the first time in Japan before commercial marketing. The device itself will soon be clinically available in Japan.In the present proof-of-concept study, we investigated the relationship between body posture and ReDS values in healthy volunteers to clarify the physiological proof of fluid shift depending on different body postures. Methods Participant SelectionHealthy volunteers aged >20 years without any past medical history were prospectively included in this single-center proofof-concept study between August and September 2021. This study was approved by the Clinical Research Review Board, University of Toyama (IRB no. MTK2020007), and written informed consent was obtained from all participants.

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Relationship Between Body Posture and Lung Fluid Volume Assessed Using a Novel Noninvasive Remote Dielectric Sensing System

et al. 2022

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“…It is recommended in the U.S. guidelines for the treatment of HFrEF to initiate and up-titrate beta-blockers to target doses before consideration of ivabradine initiation [7]. In the updated Japanese guideline, ivabradine is also recommended as an additional drug in treating HFrEF with sinus rhythm and heart rate of 75 beats/minutes or higher [4].…”

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confidence: 99%

“…Here we report a case of heart failure with reduced ejection fraction (HFrEF) occurring during chemotherapy for breast cancer. HFrEF is defined as heart failure with a left ventricular ejection fraction (LVEF) less than 40% [4]. Since the patient did not tolerate standard medication for HFrEF, she was prescribed ivabradine, which greatly improved her cardiac function.…”

Section: Introductionmentioning

confidence: 99%

Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer

Harada¹,

Shimada²,

Kubota³

et al. 2021

Cureus

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A 55-year-old woman with stage IV breast cancer was diagnosed with heart failure. Her left ventricular ejection fraction (LVEF) had decreased to 37.2%. Chemotherapy-related cardiac dysfunction (CTRCD) was suspected, and standard treatment for heart failure was initiated. After five months, her LVEF remained below 50% since she could not tolerate beta-blockers. Ivabradine was introduced, which remarkably improved her LVEF to 72.6% in only three months. Her myocardium was not dilated, which may be the reason that ivabradine was effective. Ivabradine has shown to be safe and effective in the treatment of CTRCD, and improved activities of daily living of an advanced-stage cancer patient.

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“…Patients with HF and recovered ejection fraction (HFrecEF) demonstrate relatively better clinical outcomes than patients with persistent HFrEF 2 – 6 . It was previously reported that the independent predictors for improving LVEF were young age, female sex, and an etiology of non-ischemic heart disease 3 , 6 , 7 . Meanwhile, the withdrawal of guideline-directed medical therapy (GDMT) for HF in patients with dilated cardiomyopathy and recovered LVEF led to relapse of cardiomyopathy 8 .…”

Section: Introductionmentioning

confidence: 97%

Prognosis and diastolic dysfunction predictors in patients with heart failure and recovered ejection fraction

Takada

Matsuura

Minami

et al. 2022

Sci Rep

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There is limited data on whether diastolic dysfunction in patients with heart failure (HF) and recovered ejection fraction (HFrecEF) is associated with worse prognosis. We retrospectively assessed 96 patients diagnosed with HFrecEF and created ROC curve of their diastolic function at the 1-year follow-up for the composite endpoint of cardiovascular death and HF readmission after the follow-up. Eligible patients were divided into two groups according to the cutoff value of E/e′ ratio (12.1) with the highest AUC (0.70). Kaplan–Meier analysis showed that HFrecEF with high E/e′ group had a significantly poorer prognosis than the low E/e′ group (log-rank, p = 0.01). Multivariate Cox regression analysis revealed that the high E/e′ group was significantly related to the composite endpoint (hazard ratio 5.45, 95% confidence interval [CI] 1.23–24.1). The independent predictors at discharge for high E/e′ ratio at the 1-year follow-up were older age and female sex after adjustment for covariates (odds ratio [OR] 1.07, 95% CI 1.01–1.13 and OR 4.70, 95% CI 1.08–20.5). In conclusion, HFrecEF with high E/e′ ratio might be associated with a poor prognosis. Older age and female sex were independent predictors for a sustained high E/e′ ratio in patients with HFrecEF.

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JCS/JHFS 2021 Guideline Focused Update on Diagnosis and Treatment of Acute and Chronic Heart Failure

Cited by 98 publications

References 242 publications

Relationship Between Body Posture and Lung Fluid Volume Assessed Using a Novel Noninvasive Remote Dielectric Sensing System

Relationship Between Body Posture and Lung Fluid Volume Assessed Using a Novel Noninvasive Remote Dielectric Sensing System

Ivabradine for Chemotherapy-Related Cardiac Dysfunction in Breast Cancer

Prognosis and diastolic dysfunction predictors in patients with heart failure and recovered ejection fraction

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