Jazf1 promotes prostate cancer progression by activating JNK/Slug

Sung, Yonghun; Park, Song; Park, Si Jun; Jeong, Jin Woo; Choi, Minjee; Lee, Jin‐Hee; Kwon, Wookbong; Jang, Soyoung; Lee, Mee-Hyun; Kim, Dong Joon; Liu, Kangdong; Kim, Sung Hyun; Lee, Jae Ho; Ha, Yun Sok; Kwon, Tae Gyun; Lee, Sanggyu; Dong, Zigang; Ryoo, Zae Young; Kim, Myoung Ok

doi:10.18632/oncotarget.23146

Cited by 20 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been proven in many tumours that vimentin plays an important role in tumour invasion and metastasis [38–40], and vimentin promotes GC progression by repressing E-cadherin. Previous studies have shown that JAZF1 promotes Slug expression [24], and because Slug expression significantly increases vimentin expression, this suggests an indirect means by which JAZF1 can regulate vimentin. Now, we demonstrate that JAZF1 can act as a transcriptional activator and bind to the vimentin promoter directly to positively regulate its expression.…”

Section: Discussionmentioning

confidence: 99%

“…JAZF1 as a transcriptional repressor of TR4, previous studies focused on JAZF1 function in gluconeogenesis regulation and diabetes [17, 36, 37]. Additionally, JAZF1 functions in malignancies, especially endometrial stromal tumours and prostate cancer [22–24]. Rearrangement of JAZF1-SUZ12 in endometrial stromal tumours exacerbates cancer by repressing the PRC2 complex to inhibit histone methyltransferase [22].…”

Section: Discussionmentioning

confidence: 99%

“…in endometrial stromal tumours, A JAZF1-SUZ12 fusion protein disturbs chromatin formation by inhibiting polycomb repressive complex 2 (PRC2) complexes [23]. JAZF1 is also found playing an important role in prostate cancer and diabetes [21, 23, 24]; however, the molecular mechanism by which JAZF1 acts in these diseases has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1

et al. 2019

View full text Add to dashboard Cite

Background Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types of cancer. In this study, we analysed the role and mechanism of miR-1275 in the progression and prognosis of gastric cancer (GC). Methods Target genes of miR-1275 were identified and verified by luciferase assay and Western blotting. The function of miR-1275 in invasion and metastasis was analysed in vitro and in vivo in nude mice. The signal pathway regulated by miR-1275 was examined by qRT-PCR, Western blotting and chromatin immunoprecipitation analyses. The expression of miR-1275and JAZF1 were measured in specimens of GC and adjacent non cancerous tissues. Results We identified JAZF1 as a direct miR-1275 target. miR-1275 supresses migration and invasion of GC cells in vitro and in vivo , which was restored by JAZF1 overexpression. Moreover, JAZF1 was recognized as a direct regulator of Vimentin. Knocking-down miR-1275 or overexpressing JAZF1 resulted in upregulation of Vimentin but downregulation of E-cadherin. Meanwhile, we validated in 120 GC patients specimens that low miR-1275expression and high JAZF1 mRNA expression levels were closely associated with lymph node metastasis and poor prognosis. The expression of JAZF1 in protein level displayed the correlations with Vimentin but inversely with E-cadherin. Conclusions Increased miR-1275 expression inhibited GC metastasis by regulating vimentin/E-cadherin via direct suppression of JAZF1expression, suggesting that miR-1275 is a tumour-suppressor miRNA with the potential as a prognostic biomarker or therapeutic target in GC. Electronic supplementary material The online version of this article (10.1186/s12885-019-5929-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Since we observed similar effects in HeLa Kyoto cells, it is likely that JAZF1, together with TIP60, is a general and cell-type-independent regulator of ribosome pathways. Nevertheless, since deregulation of JAZF1 expression has been strongly correlated with type 2 diabetes (T2D) and oncogenesis [ 65 , 66 , 67 , 68 , 69 ] in many studies, it is probable that the transcriptional regulatory function of this zinc finger protein is of particular importance in islet or cancer cells.…”

Section: Discussionmentioning

confidence: 99%

JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions

Procida

Friedrich

Jack

et al. 2021

IJMS

View full text Add to dashboard Cite

Histone variants differ in amino acid sequence, expression timing and genomic localization sites from canonical histones and convey unique functions to eukaryotic cells. Their tightly controlled spatial and temporal deposition into specific chromatin regions is accomplished by dedicated chaperone and/or remodeling complexes. While quantitatively identifying the chaperone complexes of many human H2A variants by using mass spectrometry, we also found additional members of the known H2A.Z chaperone complexes p400/TIP60/NuA4 and SRCAP. We discovered JAZF1, a nuclear/nucleolar protein, as a member of a p400 sub-complex containing MBTD1 but excluding ANP32E. Depletion of JAZF1 results in transcriptome changes that affect, among other pathways, ribosome biogenesis. To identify the underlying molecular mechanism contributing to JAZF1’s function in gene regulation, we performed genome-wide ChIP-seq analyses. Interestingly, depletion of JAZF1 leads to reduced H2A.Z acetylation levels at > 1000 regulatory sites without affecting H2A.Z nucleosome positioning. Since JAZF1 associates with the histone acetyltransferase TIP60, whose depletion causes a correlated H2A.Z deacetylation of several JAZF1-targeted enhancer regions, we speculate that JAZF1 acts as chromatin modulator by recruiting TIP60’s enzymatic activity. Altogether, this study uncovers JAZF1 as a member of a TIP60-containing p400 chaperone complex orchestrating H2A.Z acetylation at regulatory regions controlling the expression of genes, many of which are involved in ribosome biogenesis.

show abstract

“…TGFB1I1 (Transforming growth factor beta 1 induced transcript 1) is a coactivator of the androgen receptor, it is known to be associated with prostate cancer, and it can induce EMT, at least in astrocytomes. From the Fisher gene set, JAZF1 (JAZF zinc finger 1) has been shown to promote prostate cancer progression through JNK/Slug, leading to enhanced EMT [65]. Although these genes are just examples of genes identified by our analysis and the processes they may be involved in, this list seems to be a clear confirmation of the importance of EMT in prostate cancer [66].…”

Section: Specific Gene Clusters and Individual Genesmentioning

confidence: 57%

Enhanced identification of significant regulators of gene expression

Ehsani

Drabløs

2020

BMC Bioinformatics

View full text Add to dashboard Cite

Background: Diseases like cancer will lead to changes in gene expression, and it is relevant to identify key regulatory genes that can be linked directly to these changes. This can be done by computing a Regulatory Impact Factor (RIF) score for relevant regulators. However, this computation is based on estimating correlated patterns of gene expression, often Pearson correlation, and an assumption about a set of specific regulators, normally transcription factors. This study explores alternative measures of correlation, using the Fisher and Sobolev metrics, and an extended set of regulators, including epigenetic regulators and long non-coding RNAs (lncRNAs). Data on prostate cancer have been used to explore the effect of these modifications. Results: A tool for computation of RIF scores with alternative correlation measures and extended sets of regulators was developed and tested on gene expression data for prostate cancer. The study showed that the Fisher and Sobolev metrics lead to improved identification of well-documented regulators of gene expression in prostate cancer, and the sets of identified key regulators showed improved overlap with previously defined gene sets of relevance to cancer. The extended set of regulators lead to identification of several interesting candidates for further studies, including lncRNAs. Several key processes were identified as important, including spindle assembly and the epithelial-mesenchymal transition (EMT). Conclusions: The study has shown that using alternative metrics of correlation can improve the performance of tools based on correlation of gene expression in genomic data. The Fisher and Sobolev metrics should be considered also in other correlation-based applications.

show abstract

Jazf1 promotes prostate cancer progression by activating JNK/Slug

Cited by 20 publications

References 41 publications

MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1

MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1

JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions

Enhanced identification of significant regulators of gene expression

Contact Info

Product

Resources

About