Jaw bone changes in rats after treatment with zoledronate and pamidronate

Şenel, Figen Çizmeci; Kadıoğlu, Mine; Muci, Efnan; Çankaya, Mustafa; Pampu, A. Alper; Ersöz, Şafak; Günhan, O

doi:10.1016/j.tripleo.2009.10.011

Cited by 67 publications

(64 citation statements)

References 33 publications

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“…Considering the current discussion of MRONJ clinical stage classification a very interesting fact was observed in this study 21,22 . In a literature review of experimental models on MRONJ 15 , authors considered 10 small animal models [23][24][25][26][27][28][29][30][31][32] , and 5 large animal models 15,[33][34][35][36][37] . In all studies, when used as the extraction inducing factor, premolars and molars were used [23][24][25][26][27][28][29][30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

“…In a literature review of experimental models on MRONJ 15 , authors considered 10 small animal models [23][24][25][26][27][28][29][30][31][32] , and 5 large animal models 15,[33][34][35][36][37] . In all studies, when used as the extraction inducing factor, premolars and molars were used [23][24][25][26][27][28][29][30][31][32] . From 10 studies with rodents, which were used different induction protocols, only 5 revealed MRONJ lesions clinically detected 24,26,28,29,32 , however, in 9 studies, osteonecrosis was detected microscopically [23][24][25][26][27][28][29][30]32 .…”

Section: Discussionmentioning

confidence: 99%

“…In all studies, when used as the extraction inducing factor, premolars and molars were used [23][24][25][26][27][28][29][30][31][32] . From 10 studies with rodents, which were used different induction protocols, only 5 revealed MRONJ lesions clinically detected 24,26,28,29,32 , however, in 9 studies, osteonecrosis was detected microscopically [23][24][25][26][27][28][29][30]32 . Only one study did not reveal this information 31 .…”

Section: Discussionmentioning

confidence: 99%

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Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model

Curra

Cardoso

Júnior³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To evaluate a modified experimental model for medication-related osteonecrosis of the jaw (MRONJ) through the upper right central incisor extraction followed by intravenous bisphosphonate administration. METHODS:Forty five rats underwent the upper right central incisor tooth extraction were divided in 2 groups: Group I -experimental group, 30 rats received an intravenous administration protocol of zoledronic acid 35μg/kg into the tail vein every two weeks, totalizing four administrations, during eight weeks of administration, previously the extraction, and Group II -control group, 15 rats didn't received any medication before extraction. The groups were subdivided in postoperative periods: 14/28/42 days. Clinical analysis and microtomography were performed to verify the presence of osteonecrosis. In addition, descritive histological analysis of hematoxylineosin stained sections was performed to evaluate the presence of osteonecrosis or necrotic foci. RESULTS:Twelve (40%) rats, from experimental group, showed clinical signs of MRONJ (p=0.005), however, all samples showed imaginologic findings like osteolysis and loss of integrity of the cellular walls (p≤0.001). Microscopic evaluation revealed osteonecrosis areas with microbial colonies and inflammatory infiltrate (p≤0.001). In the control group, all animals presented the chronology of a normal wound healing. CONCLUSIONS:The presence of medication-related osteonecrosis of the jaw after maxillary central incisor extraction in rats. This new experimental model may be considered an option for the study of MRONJ.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model

Curra

Cardoso

Júnior³

et al. 2016

Acta Cir. Bras.

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“…However, BRONJ may develop even without tooth extraction. The incidence of N-BP-associated BRONJ is 40-47% in reported animal studies 5,6) . N-BP drugs are used to treat patients with cancer and immunological diseases such as rheumatism; steroids are often also required in these patients under various clinical conditions.…”

Section: Introductionmentioning

confidence: 99%

Jawbone Changes in Sodium Zoledronic Acid- and Dexamethasone-Treated Rats

Tezuka

Tanaka

2016

J. Hard Tissue Biology.

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Previous studies have evaluated bisphosphonate-related osteonecrosis of the jaw (ONJ) after tooth extraction with concurrent administration of bisphosphonate zoledronic acid (ZOL) and steroids. However, details of jawbone changes after administration of ZOL and steroids without tooth extraction remain unclear. In this study, we administered ZOL and dexamethasone (DEX) in rats and compared changes in the jawbone with and without tooth extraction. The right maxillary first molar (M 1 ) was extracted from 8-week-old rats treated with ZOL, ZOL+DEX or DEX. The right maxillary M 1 region as the extraction sample and the left maxillary M 1 region as the non-extraction sample were compared with macroscopic, radiological, histologic and immunohistochemical examinations. In the extraction samples, we detected incomplete mucosal closure macroscopically and found ONJ on histological examination. In addition, immunohistochemical and threedimensional analysis of trabecular bone structure showed inhibition of remodeling and angiogenesis in the extraction samples. In the non-extraction samples, we observed inhibition of remodeling, reduced activity of osteoclasts and osteoblasts and suppression of angiogenesis. These findings demonstrate that ONJ can develop under the mucosa with ZOL and DEX treatment, even without invasive procedures. The data suggest that ZOL and DEX can induce ONJ in rats under both invasive and noninvasive conditions because ZOL suppresses osteoclast activity and DEX inhibits remodeling by suppressing osteoblast activity. The results also suggest that surgical stress, such as tooth extraction or bacterial infection, might lead to more severe bisphosphonaterelated ONJ.

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“…A six cycle chemotherapy regime was given since 2012. And 7 months ago bone scan confirmed skeletal metastasis in the vertebral column (see Figure 1) and 12 cycle chemotherapy regime was given on 2016 (Zometa 4mg/ month) intravenously [11].…”

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confidence: 99%